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Associate Professor of Biomedical Engineering

• About

  Research in the Biomembrane Lab focusses on transport of ions and small molecules across lipid bilayer membranes and across synthetic membrane materials.  In the context of lipid bilayer membranes, we are interested in ion channel proteins, pore-forming peptides, and ATP-driven efflux pumps.  We study the biophysics of these proteins with regard to their importance for autoimmune diseases, resistance to chemotherapy in cancer treatment, or possible pathologic mechanism contributing to Alzheimer’s disease.  In the context of synthetic membrane materials, we pursue a bio-inspired approach to single molecule transport and sensing.  We study these processes by resistive pulse sensing in nanopores and are motivated by the capability of nanopore sensing to reveal multiple biophysical parameters from the translocation of single proteins through these pores.  For more information, please refer to: http://www.bme.umich.edu/labs/biomembrane/ .