The goal of this course is to understand the mechanisms by which stressful stimuli change neural function and alter physiology and behavior. We will examine a number of stress-sensitive systems, with a particular focus on the hypothalamic pituitary adrenal (HPA) axis. We will examine topics related to the effects of acute and repeated stress exposure on physiological systems and various aspects of behavior through the lifespan. Through student-led discussions, we will discuss readings relevant to each topic.