MCDB 417 - Chromosome Structure and Function
Section: 001
Term: FA 2008
Subject: Molecular, Cellular, and Developmental Biology (MCDB)
Department: LSA Molecular, Cellular, and Developmental Biology
Requirements & Distribution:
Waitlist Capacity:
Advisory Prerequisites:
This course counts toward the 60 credits of math/science required for a Bachelor of Science degree.
May not be repeated for credit.
Rackham Information:
Rackham credit requires additional work.
Primary Instructor:

This course is an introduction to the chromosome, focusing on understanding how chromosome structure affects its functions, both in interphase (gene regulation) and mitosis (chromosome segregation). Topics will include the step-wise assembly of interphase chromatin and mitotic chromosomes, the properties of active euchromatin and inactive heterochromatin, as well as the functions of specialized parts of chromosomes, such as centromeres and telomeres. We will also explore the impact of chromosome and chromatin structure on the epigenetic reprogramming of the cell during development, cancer progression and cloning. Each topic will be introduced by a lecture that also incorporates in-class group activities designed to assimilate the knowledge students gained in lecture while completing reading assignments at home. This lecture and activity will be followed by reading and in-class discussion of primary scientific literature to investigate the genetic, biochemical, and cytological methods for defining our current knowledge about chromosomes.

Intended audience: Primarily upper-level undergraduates concentrating in CMB or another biology-related program. It will also be of interest to graduate students in their first year of study.

Course Requirements: Students will be evaluated based on presentations of assigned papers, and a final written research proposal. Weekly, 1-page reports on an assigned research paper (60%); a final written scientific proposal of 5-10 pages (20%) and participation in discussion and class activities (20%).

Class Format: We will use a combination of lecture, literature review, and in class discussion to explore genetic, biochemical, and cytological methods for defining our current knowledge about chromosomes. Three hours weekly in lecture format that also incorporates in-class group activities designed to help assimilate the knowledge. There will also be discussion of primary scientific literature.

MCDB 417 - Chromosome Structure and Function
Schedule Listing
001 (LEC)
TuTh 10:00AM - 11:30AM
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