CHEM 351 - Fundamentals of Biochemistry
Section: 001
Term: WN 2009
Subject: Chemistry (CHEM)
Department: LSA Chemistry
Requirements & Distribution:
Credit Exclusions:
No credit for those currently or previously enrolled in BIOLOGY 310 or BIOLCHEM 415.
Advisory Prerequisites:
Completion of BIOLOGY 172 or equivalent; CHEM 210 and completion or concurrent in CHEM 215.
This course counts toward the 60 credits of math/science required for a Bachelor of Science degree.
May not be repeated for credit.
Primary Instructor:

This course is designed to serve as an introduction to biochemistry for students intending to pursue the BS concentration in biochemistry and for others who are interested in gaining an overview of the fundamental chemistry underlying cellular functions. The material includes an introduction to the structures of biological macromolecules and an overview of the fundamental cellular processes associated with metabolism, biosynthesis, and replication. It is taught from a chemical perspective with an emphasis of understanding biochemical phenomena through chemical structure and mechanism.


  • Overview of cellular structure and function
  • Cell organelles
  • Structure and functions of biological macromolecules and assemblies
  • Amino acid structures and pKa
  • Peptide bond and protein structure – primary, secondary, tertiary and quaternary
  • Nucleotide structure and hydrogen bonding
  • Nucleic acid structure - DNA and RNA
  • Lipid structures and membrane structures
  • Metabolism
  • ATP and “high energy” bonds
  • NAD/NADH and redox potential
  • Concept of metabolic pathways
  • Enzyme catalysis; kcat and Km
  • Regulation of pathways – feedback inhibition; phosphorylation
  • Glycolysis
  • Citric acid cycle
  • Fatty acid degradation and biosynthesis
  • Respiration and oxidative phosphorylation
  • The central dogma
  • DNA replication; polymerases, topoisomerases, helicases
  • DNA Transcription - RNA polymerase
  • RNA translation – the ribosome Suggested Text B: Fundamental Biochemistry by Pratt & Cornely (Wiley)

Crs Requirements: Written mid-term exam (~60% of credit) and cumulative final exam (~40%)

Intended Audience: Students at sophomore/junior level who intend to concentrate in Biochemistry. Also those interested in chemical principles of biochemistry, such as Chemistry and MCDB concentrators and pre-medical students.

Class Format: 3 hour per week in lecture format plus 1 hour per week recitation led by a GSI.

CHEM 351 - Fundamentals of Biochemistry
Schedule Listing
001 (LEC)
MWF 12:00PM - 1:00PM
NOTE: Data maintained by department in Wolverine Access. If no textbooks are listed below, check with the department.

Essential Biochemistry, by Pratt & Cornely
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