Traditional philosophical questions about the nature of time and space have been strikingly influenced in the twentieth century by the results of contemporary physical science. At the same time, the important current physical theories of space and time rest explicitly or implicitly on deep-rooted philosophical assumptions. The purpose of this course is to study the mutual interaction between science and philosophy as illustrated in problems about space and time. Typical topics to be considered include the status of knowledge about the structure of space and time, substantial versus relational theories of space-time, spatio-temporal order and causal order, and the so-called problem of the direction of time. This course can be appreciated by students who have either a background in philosophy — especially logic and philosophy of science, metaphysics, epistemology — or background in physical science or mathematics. An attempt is made in this course to introduce the fundamental ideas of both philosophy and science at a level which can be understood by those without extensive background so students need not be proficient in both science and philosophy to benefit from the course. The primary text is L. Sklar's Space, Time, and Spacetime. There are additional readings from such authors as Reichenbach, Poincaré, Grunbaum, Smart, Wheeler, and others.