Although this course is designed principally to develop mathematics for application to problems of science and engineering, it also serves as an important bridge for students between the calculus courses and the more demanding advanced courses. Students are expected to learn to read and write mathematics at a more sophisticated level and to combine several techniques to solve problems. Some proofs are given, and students are responsible for a thorough understanding of definitions and theorems. Students should have a good command of the material from MATH 215, and 216 or 316, which is used throughout the course. A background in linear algebra, e.g. MATH 217, is highly desirable, as is familiarity with Maple software. Topics include a review of curves and surfaces in implicit, parametric, and explicit forms; differentiability and affine approximations; implicit and inverse function theorems; chain rule for 3-space; multiple integrals; scalar and vector fields; line and surface integrals; computations of planetary motion, work, circulation, and flux over surfaces; Gauss' and Stokes' Theorems; and derivation of continuity and heat equation. Some instructors include more material on higher dimensional spaces and an introduction to Fourier series. MATH 450 is an alternative to MATH 451 as a prerequisite for several more advanced courses. MATH 454 and 555 are the natural sequels for students with primary interest in engineering applications.