This course will extend the basic knowledge of molecular cell biology into cellular disorders in human diseases. Selected topics on human diseases in which basic cell biological processes are defective will be explored in-depth using contemporary primary cell biology literature as the principal resource. An emphasis will be placed on the analysis of experimental design, methodology, and interpretation of data. Basic principles will be reinforced in lectures. Topics of investigation will include, but are not limited to, cellular defects in protein folding, targeting, and processing in neurodegenerative diseases such as Alzheimer’s disease; cell growth, cancer, and programmed cell death; cholesterol metabolism and atherosclerosis; insulin processing, secretion, and diabetes; and pathogen-cell interaction.
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This course is intended for upper-level undergraduates and graduate students. It is appropriate for students interested in cell biology, biochemistry, molecular biology, pharmacology, and genetics.
The course will be comprised of lectures, in-class discussions, paper readings, and presentations.