This seminar will explore territory at and near the intersection of epistemology and philosophy of science. Other things being equal, philosophers and scientists prefer simpler hypotheses to less simple ones. What sort of reasons can one give for this preference? Does our preference have the same epistemic standing in the philosophical context as in the scientific context? Can one deny that simplicity is a guide to truth in one or another domain without falling into skepticism? Amongst others, we will consider the accounts of simplicity offered by: various sorts of confirmation theory; naturalists about methodology; social epistemologists; advocates of conservativism in epistemology; fans of Reichenbach's pragmatic vindication of induction. Some topics and themes that will arise along the way: genuine cases of underdetermination of theory by evidence in the physical sciences; alienation in epistemology; the constantly shifting notions of simplicity invoked in the sciences.