EEB 512 - Molecular and Genomic Evolution
Section: 001
Term: FA 2017
Subject: Ecology and Evolutionary Biology (EEB)
Department: LSA Ecology & Evolutionary Biology
Requirements & Distribution:
With permission of instructor.
Advisory Prerequisites:
BIOLOGY 305 and one upper-level course in either Molecular or Evolutionary Biology; permission of instructor and Graduate standing.
This course counts toward the 60 credits of math/science required for a Bachelor of Science degree.
May not be repeated for credit.
Primary Instructor:

This course examines processes and patterns of evolution at the molecular level, as well as methods of phylogenetic analysis using molecular characters, such as amino acid sequences, DNA sequences, and features of genome organization. These evolutionary topics and methods are key components in the developing field of bioinformatics.


  • Evolution of amino acid sequences; sequence alignment
  • Evolution of DNA sequences
  • Synonymous and nonsynonymous distances
  • Phylogenetic methods (parsimony)
  • Phylogenic methods (distance, likelihood, Bayesian)
  • Reliability of phylogenetic methods (bootstrap and other methods)
  • Molecular clock
  • Male-driven evolution
  • Ancestral sequence reconstruction
  • Molecular population genetics
  • Neutral theory
  • Detecting natural selection
  • Rate of protein sequence evolution
  • Evolution of gene expression
  • Evolution by gene duplication
  • Horizontal gene transfer
  • Evolutionary systems biology


  • Required:
    Molecular Evolution and Phylogenetics (Nei and Kumar 2000)
  • Recommended:
    Molecular Evolution (Li 1997)
    Inferring Phylogenies (Felsenstein 2004)

Course Requirements:

Course grades are based on the following:

  • Five problem sets (take-home), 50%
  • Research paper (due Dec. 19), 50%

Intended Audience:

No data submitted

Class Format:

No data submitted

EEB 512 - Molecular and Genomic Evolution
Schedule Listing
001 (LEC)
MW 1:00PM - 2:30PM
NOTE: Data maintained by department in Wolverine Access. If no textbooks are listed below, check with the department.

ISBN: 0195135857
Molecular evolution and phylogenetics, Author: Masatoshi, Nei, Sudhir Kumar., Publisher: Oxford University Press [Online-Au 2000
ISBN: 1605354694
Molecular and Genome Evolution, Author: Graur, Publisher: Sinauer 1 2016
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