BIOPHYS 440 - Biophysics of Diseases
Section: 001
Term: FA 2018
Subject: Biophysics (BIOPHYS)
Department: LSA Biophysics
Credits:
3
Requirements & Distribution:
BS
Waitlist Capacity:
7
Advisory Prerequisites:
BIOPHYS 370 or CHEM 370 or PHYSICS 370.
BS:
This course counts toward the 60 credits of math/science required for a Bachelor of Science degree.
Repeatability:
May not be repeated for credit.
Primary Instructor:

This course deconstructs current and emerging diseases in terms of the malfunctioning of nucleic acids, proteins, and membranes and interactions between them. The diseases covered will include Alzheimer’s, Parkinson’s, Creutzfeldt-Jakob disease (or Mad-Cow disease), HIV, a variety of bacterial infections, and other biological disorders. A variety of biophysical methods for dissecting diseases at the atomic level will be surveyed, including NMR spectroscopy, X-ray crystallography, cryo-electron microscopy, single molecule imaging, and computational methods.

The course will emphasize how a basic biophysical understanding of diseases can guide the rational design of therapeutics, to include:

  • Infectious diseases
  • The Molecules of Life: Biophysical Principles
  • Viral Infections
  • Bacterial Infections
  • Health Conditions
  • Rational Approaches to Drug Discovery

Textbooks:

  • Cellular Signaling in Health and Disease (Springer, 2009), Beckerman, Martin;
  • Methods in Molecular Biophysics: Structure, Dynamics, Function (Cambridge, 2007), Serdyuk, Igor N.; Zaccai, Nathan R.; Zaccai, Joseph.

Course Requirements:

Biweekly problem-solving homework assignments, assigned readings, weekly quizzes, two exams (20 pts each), one final paper (5-7 pages)that critically explores the biophysical basis for a student-chosen human disease and discusses how an in-depth biophysical understanding of the disease process can help in the rational design of therapeutics. Students will also present their final papers in class (30 pts ).

Intended Audience:

Upper level undergraduates and graduate students in the biological, biophysical, and biochemical sciences.

Class Format:

Lecture format 3 hpw

BIOPHYS 440 - Biophysics of Diseases
Schedule Listing
001 (LEC)
P
21985
Closed
0
 
-
MW 8:30AM - 10:00AM
NOTE: Data maintained by department in Wolverine Access. If no textbooks are listed below, check with the department.


ISBN: 9780125870733
Crystallography made crystal clear : a guide for users of macromolecular models, Author: Gale Rhodes., Publisher: Academic Press [u.a.] 3. ed. 2006
Optional
ISBN: 9780521815246
Methods in molecular biophysics : structure, dynamics, function, Author: Igor N. Serdyuk ; Nathan R. Zaccai ; Joseph Zaccai., Publisher: Cambridge Univ. Press 1. publ. 2007
Optional
ISBN: 9780815341031
NMR for physical and biological scientists, Author: Thomas C. Pochapsky and Susan Sondej Pochapsky., Publisher: Garland Science 2006
Optional
ISBN: 9780387312781
Principles of fluorescence spectroscopy, Author: Joseph R. Lakowicz., Publisher: Springer 3. ed. 2006
Optional
ISBN: 9780195182187
Three-Dimensional Electron Microscopy of Macromolecular Assemblies : Visualization of Biological Molecules in Their Native State, Author: 2. ed., Publisher: Oxford University Press 2nd ed. 2006
Optional
Syllabi are available to current LSA students. IMPORTANT: These syllabi are provided to give students a general idea about the courses, as offered by LSA departments and programs in prior academic terms. The syllabi do not necessarily reflect the assignments, sequence of course materials, and/or course expectations that the faculty and departments/programs have for these same courses in the current and/or future terms.

Click the button below to view historical syllabi for BIOPHYS 440 (UM login required)

View Historical Syllabi
The CourseProfile (ART) system, supported by the U-M Provost’s 3rd Century Initiative through a grant to the Digital Innovation Greenhouse, provides additional information about: course enrollments; academic terms and instructors; student academic profiles (school/college, majors), and previous, concurrent, and subsequent course enrollments.

CourseProfile (ART)