CHEM 520 - Methods of Biophysical Chemistry
Fall 2021, Section 001
Instruction Mode: Section 001 is  In Person (see other Sections below)
Subject: Chemistry (CHEM)
Department: LSA Chemistry
See additional student enrollment and course instructor information to guide you in your decision making.


Requirements & Distribution:
Waitlist Capacity:
Advisory Prerequisites:
CHEM 463, BIOLCHEM 415, or CHEM 420; permission of course director.
This course counts toward the 60 credits of math/science required for a Bachelor of Science degree.
May not be repeated for credit.
Primary Instructor:
Start/End Date:
Full Term 8/30/21 - 12/10/21 (see other Sections below)
NOTE: Drop/Add deadlines are dependent on the class meeting dates and will differ for full term versus partial term offerings.
For information on drop/add deadlines, see the Office of the Registrar and search Registration Deadlines.


This course is the first of a two-term Biophysical Chemistry series BIOPHYS 520/521, but it can be taken as stand-alone course as well. BIOPHYS 520 will introduce and explain the physicochemical properties of biological macromolecules and their complexes, mostly in solution. The course offers an overview of protein and nucleic acid structures. Intra- and inter-molecular forces, helix-coil transitions, and protein folding will be treated in a thermodynamical context.

Thermodynamics of solutions, configurational statistics, ligand interactions, multi-site interactions, and cooperativity are treated in depth. Kinetics and thermodynamics of protein-ligand binding are discussed. The role of dynamics in protein function is introduced.

Currently, biophysical, biochemical, and pharmacochemical research literature is full with papers interpreting the properties of biological macromolecules on the basis of their three-dimensional structure. This course will expand on that concept by offering a rigorous background in energetics, folding, interactions, and dynamics. As such the course is important to any student who has to deal with the concepts of biomolecular function and structure such as biochemists, molecular biophysicists, mathematical biologists, and molecular pharmacologists. This course will also serve as a basis for the graduate student who will be specializing in any of these topics for thesis research.

Instructional material: Dill & Bromberg, Molecular Driving Forces, 2003 and course packs.

Evaluation: homework (40%), midterm exam (30%) and final exam (30%).


CHEM 520 - Methods of Biophysical Chemistry
Schedule Listing
001 (LEC)
 In Person
TuTh 1:00PM - 2:30PM
8/30/21 - 12/10/21

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Syllabi are available to current LSA students. IMPORTANT: These syllabi are provided to give students a general idea about the courses, as offered by LSA departments and programs in prior academic terms. The syllabi do not necessarily reflect the assignments, sequence of course materials, and/or course expectations that the faculty and departments/programs have for these same courses in the current and/or future terms.

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