The recent completion of the human genome opens the door to exciting new opportunities in the biomedical sciences. Integrative Genomics focuses on the study of functional biology in genetically engineered animal models. An appreciation of genetic variables, including gender and genetic background, biological variables, including organ function and issues relating to aging, and environmental variables, including, nutrition, exercise, stress, and pathogens is a central feature of the class. It is the study of the inherent complexities of genes, biology, and environment in animals that forms the unique underpinnings of the exciting new field of Integrative Genomics. The course features limited class size, and faculty from several different departments in the Medical School. Unique educational features of the class include student developed grants, oral presentations, student-led study section evaluations of grants, and no tests.