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Jianzhi George Zhang
Department of Ecology and Evolutionary Biology, University of Michigan
1075 Natural Science Building, 830 North University Avenue, Ann Arbor, MI 48109-1048, USA
Phone: 734-763-0527; Fax: 734-763-0544; Email: jianzhi@umich.edu
EDUCATION
1988–1992 B.S. in Genetics, Fudan University, Shanghai, China
1992–1994 M.S. Program in Genetics, Fudan University, Shanghai, China
1994–1998 Ph.D. in Genetics, Pennsylvania State University, University Park, PA.
Thesis: Patterns and mechanisms of molecular evolution: statistical methods and data analysis. Advisor: Dr. Masatoshi Nei
EMPLOYMENT
1999–2001 Fogarty Postdoctoral Fellow, National Institute of Allergy and Infectious
Diseases, National Institutes of Health. Advisor: Dr. Helene F. Rosenberg
2001–2005 Assistant Professor, Department of Ecology and Evolutionary Biology, University
of Michigan
2005– Associate Professor, Department of Ecology and Evolutionary Biology,
University of Michigan
CURRENT FUNDING
“RNases for understanding the origin of new gene function” (R01GM67030), National Institute of General Medical Sciences, National Institutes of Health, 1/1/03-12/31/08. PI.
“Evolution of vertebrate sensory genes” (R01GM80285), National Institute of General Medical Sciences, National Institutes of Health, 7/1/07-6/30/11. PI.
“Understanding duplicate gene evolution by computational and experimental functional genomics”, Center for Computational Medicine and Biology, University of Michigan, 11/1/06-10/31/08. PI (Co-PI: Anuj Kumar).
RESEARCH INTERESTS
Molecular basis of adaptation, evolution of duplicate genes, evolutionary genomics and systems biology, genetic basis of human origins and primate evolution, vertebrate sensory gene evolution.
TEACHING AT UNIVERSITY OF MICHIGAN
BIO305-Genetics (4 terms, with Janine Maddock or Tzvi Tzfira)
EEB490-Population Genetics (2 terms)
EEB512-Molecular Systematics and Evolution (3 terms; 2 with David Mindell)
EEB800-Molecular Evolution Journal Club (5 terms)
PROFESSIONAL SERVICES
Elected Secretary, Society for Molecular Biology and Evolution (2007-2009)
Editor (2004-), Gene
Associate Editor (2004-), Molecular Biology and Evolution
Editorial Board member (2007-), Frontiers of Biology in China
Editorial Board member (2007-), Journal of Systematics and Evolution
Regular member, NIH Study Section on Genetic Variation and Evolution, 2007-2011.
SelectED RECENT PUBLICATIONS
Liao, B.-Y., and J. Zhang (2008) Null mutations in human and mouse orthologs frequently result in different phenotypes. Proc. Natl. Acad. Sci. USA, in press.
Qian, W., and J. Zhang (2008) Evolutionary dynamics of nematode operons: easy come, slow go. Genome Res. 18:412-421.
Bakewell, M. A., P. Shi, and J. Zhang (2007) More genes underwent positive selection in chimpanzee evolution than in human evolution. Proc. Natl. Acad. Sci. USA 104:7489-7494.
Shi, P., and J. Zhang (2007) Comparative genomic analysis identifies an evolutionary shift of vomeronasal receptor gene repertoires in the vertebrate transition from water to land. Genome Res. 17:166-174.
Wang, Z., and J. Zhang (2007) In search of the biological significance of modular structures in protein networks. PLoS Comput. Biol. 3:1011-1021.
Zhang, J. (2006) Parallel adaptive origins of digestive RNases in Asian and African leaf monkeys. Nat. Genet. 38:819-823.
Wang, X., W. E. Grus, and J. Zhang (2006) Gene losses during human origins. PLoS Biol. 4:366-377.
Cho, S., Z. Y. Huang, D. R. Green, D. R. Smith, and J. Zhang (2006) Evolution of the complementary sex-determination gene of honey bees: balancing selection and trans-species polymorphisms. Genome Res. 16:1366-1375.
He, X., and J. Zhang (2006) Why do hubs tend to be essential in protein networks? PLoS Genet. 2:826-834.
Liao, B.-Y., and J. Zhang (2006) Evolutionary conservation of expression profiles between human and mouse orthologous genes. Mol. Biol. Evol. 23:530-540.
Grus, W. E., P. Shi, Y. P. Zhang, and J. Zhang (2005) Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals. Proc. Natl. Acad. Sci. USA 102:5767-5772.
He, X. and J. Zhang (2005) Gene complexity and gene duplicability. Curr. Biol. 15:1016-1021.
He, X. and J. Zhang (2005) Rapid subfunctionalization accompanied by prolonged and substantial neofunctionalization in duplicate gene evolution. Genetics 169:1157-1164.
Zhang, J. and D. M. Webb (2003) Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. Proc. Natl. Acad. Sci. USA 100:8337-8341.
Podlaha, O and J. Zhang (2003) Positive selection on protein-length in the evolution of a primate sperm ion channel. Proc. Natl. Acad. Sci. USA 100:12241-12246.
Zhang, J. (2003) Evolution of the human ASPM gene, a major determinant of brain size. Genetics 165:2063-2070.
Zhang, J. (2003) Evolution by gene duplication-an update. Trends Ecol. Evol. 18:292-298.
Zhang, J., D. M. Webb, and O. Podlaha (2002) Accelerated protein evolution and origins of human-specific features: FOXP2 as an example. Genetics 162:1825-1835.
Zhang, J., Y.-P. Zhang, and H. F. Rosenberg (2002) Adaptive evolution of a duplicated pancreatic ribonuclease gene in a leaf-eating monkey. Nat. Genet. 30:411-415.
Zhang, J. and H. F. Rosenberg (2002) Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates. Proc. Natl. Acad. Sci. USA 99:5486-5491.
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