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Fields of study
Theoretical biology, ecology and evolution of infectious diseases
Academic background
B.S. Biological Sciences from Stanford University, conferred 4/97. Certificate in Complex Systems from University of Michigan, conferred 12/03.
Research interests
My research focuses on the ecology and evolution of infectious diseases. I use a combination of theoretical modeling approaches and statistical data analyses to understand the processes that give rise to the dynamic and evolutionary patterns of pathogens.
More specifically, my interests fall into three main areas:
- The regulation of infectious disease dynamics
- The determinants of genetic and antigenic diversity patterns in pathogen populations
- Pathogen adaptation to environmental change
My thesis focused on the dynamics and evolution of Vibrio cholerae, the bacterium that causes cholera. Since receiving my PhD in 2005, I have devoted most of my research time to understanding the dynamics and evolution of RNA viruses, most notably interpandemic influenza.
Mentor
Mercedes Pascual
Select publications
Koelle, K., Cobey, S., Grenfell, B., & Pascual, M. (2006) Epochal evolution shapes the phylodynamics of interpandemic influenza A (H3N2) in humans. Science. 314. pp. 1898-1903.
Koelle, K., Pascual, M., Yunus, M. (2006) Serotype cycles in cholera dynamics. Proceedings of the Royal Society, Series B, Biological Sciences. 273. pp. 2879-2886.
Pascual, M., Koelle, K., Dobson, A. (2006) Hyperinfectivity in Cholera: A New Mechanism for an Old Epidemiological Model? PLoS Medicine. 3 (6). p. e280.
Koelle, K., Rodó, X., Pascual, M., Yunus, M., & Mostafa, G. (2005) Refractory periods to climate forcing in cholera dynamics. Nature. 436. pp. 696-700.
Koelle, K., Pascual, M., & Yunus, M. (2005) Pathogen adaptation to seasonal forcing and climate change. Proceedings of the Royal Society, Series B, Biological Sciences.272. pp. 971-977.
Koelle, K. & Vandermeer, J. (2005) Dispersal-induced desynchronization: from metapopulations to metacommunities. Ecology Letters. 8(2). pp. 167-175.
Buckee, C., Koelle, K., Mustard, M. & Gupta, S. (2004) The effects of host contact network structure on pathogen diversity and strain structure. PNAS. 101(29). pp.10839-10844.
Koelle, K. & Pascual, M. (2004) Disentangling extrinsic from intrinsic factors in disease dynamics: a nonlinear time series approach with an application to cholera. The American Naturalist 163(6), pp.901-913.
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