Promoting axonal regrowth after injury

Author(s): Xin Xiong, Xin Wang, Ronny Ewanek, Pavan Bhat, Aaron DiAntonio, Catherine A. Collins

Regenerating axon

Description:

Regenerative responses to axonal injury involve changes in gene expression; however, little is known about how such changes can be induced from a distant site of injury. In this study, we describe a nerve crush assay in Drosophila melanogaster to study injury signaling and regeneration mechanisms.

We find that Wallenda (Wnd), a conserved mitogen-activated protein kinase (MAPK) kinase kinase homologous to dual leucine zipper kinase, functions as an upstream mediator of a cell-autonomous injury signaling cascade that involves the c-Jun NH2-terminal kinase MAPK and Fos transcription factor.




Publication Information:

Name of Periodical: J. Cell Biol.

Volume Number: 191

Issue Number: 1

Year of Publication: 2010

Page Numbers: 211-223