The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle

Author(s): Danming Tang, Yi Xiang, Stefano De Renzis, Jochen Rink, Gen Zheng, Marino Zerial, Yanzhuang Wang

ubiquitin ligase HACE1

Description:

The Golgi membrane is fragmented during mitosis and is subsequently fused following cell division and this process is known to be controlled by ubiquitination. In this study, the ubiquitin ligase HACE1 is shown to be targeted to the Golgi membrane and is required for fusion after the completion of mitosis.




Publication Information:

Name of Periodical: Nature Communications

Year of Publication: 2011