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Two Classes of Dosage Compensation Complex Binding Elements along Caenorhabditis elegans X Chromosomes
Author(s): Timothy A. Blauwkamp, Gyorgyi Csankovszki
Dosage compensation equalizes X-linked gene products between the sexes. In Caenorhabditis elegans, the dosage compensation complex (DCC) binds both X chromosomes in XX animals and halves the transcription from each. The DCC is recruited to the X chromosomes by a number of loci, rex sites, and is thought to spread from these sites by an unknown mechanism to cover the rest of the chromosome. Here we describe a novel class of DCC-binding elements that we propose serve as "way stations" for DCC binding and spreading.
Name of Periodical: Mol. Cell. Biol.
Volume Number: 29
Issue Number: 8
Year of Publication: 2009