01-02 LS&A Bulletin

Courses in Biophysics (Division 329)

BIOPHYS 503 / CHEM 603. Biomolecular NMR: Structure & Dynamics in Solution & Solids.: Graduate standing. (3).; After a classical introduction into 2D NMR, principles of multidimensional NMR will be treated, including quantum mechanical methods such as Density Matrices, Product Operators, Propagators and perturbation theory. Biomolecular applications of two-dimensional proton NMR and three- and four-dimensional heteronuclear NMR will be extensively covered. Methods applicable for solution as well as for solid samples will be introduced. Applications center on protein structure determination but nucleic acids NMR and relaxation experiments for the detection of molecular dynamics will be treated as well. An introduction into solid-state NMR will focus around the methods such as cross polarization, MAS, line-narrowing multiple-pulse techniques. Applications will be covered in the last lecture.
BIOPHYS 520 / CHEM 520. Biophysical Chemistry I.: Chem. 463, Biol. Chem. 415, or Chem 420; permission of course director. (3).; This course is the first of a two term biophysical chemistry series Biophysics 510/511. The course offers an overview of protein, nucleic acid, lipid and carbohydrate structures.
BIOPHYS 521 / CHEM 521. Biophysical Chemistry II.: Chem. 461, Biol. Chem. 415, and Chem. 430 or equivalent; and permission of course director. (3).; This course gives background applications of several physical techniques used in biophysical research. General principles of spectroscopy are explained. Macromolecular structure determination by X-ray diffraction and two-dimensional NMR are treated in detail. IR, Raman, CD, EXAFS, EPR, and ESEEM are introduced.
BIOPHYS 601. Spec Aspects.: Graduate Standing. (3).
BIOPHYS 602 / CHEM 602 / CMBIOL 602. Protein Structure.: Physical Chemistry. Graduate standing. (2).
BIOPHYS 608 / BIOLOGY 608 / PHYSICS 608. Biophysical Principles of Microscopy.: Physics 405 and Graduate Standing. (3).
BIOPHYS 642 / MICRBIOL 642. Molecular and Cellular Immunology III.: Biology 305 and Biol. Chem. 415 and Biology 436/Microbiology 502; Graduate standing. (1).; This one credit course will consist of lectures and discussions pertaining to receptor-ligand interactions in the immune system. The goal of the course is to provide students a broad overview of the structural basis of immune function by reviewing recent literature.
BIOPHYS 801. Seminar by Molecular Biophysics Trainees.: Graduate standing. (1).; Students in Molecular Biophysics fulfill the requirements for a Ph.D. in either Biological Chemistry, Biophysics, Chemistry, or Physics. Training in Molecular Biophysics aims to develop independent investigators who will contribute in significant ways to advances in understanding structural and cellular biology at the molecular level. Students concentrating in Molecular Biophysics elect coruses in areas such as protein structure and function, techniques in NMR and crystallography, and spectroscopic methods.
BIOPHYS 811. Seminar in Physical Methods in Biophysics: Diffraction.: Graduate standing. (2-3).
BIOPHYS 813. Seminar in Physical Methods in Biophysics: Spectroscopy.: Graduate standing. (2-3).
BIOPHYS 890. Introduction to Research.: Research rotations: Primarily for students in the Biophysics Graduate Program. Graduate Standing. (1-4). (INDEPENDENT).; The main focus is to offer research training in the applications of physics-based techniques to biological systems ranging in complexity from single molecules to whole cells and tissues.
BIOPHYS 990. Dissertation/Precandidate.: Election for dissertation work by doctoral student not yet admitted as a Candidate. Graduate Standing. (1-8; 1-4 in the half-term). (INDEPENDENT). May be repeated for credit.; Election for dissertation work by doctoral student not yet admitted as a Candidate.
BIOPHYS 995. Dissertation/Candidate.: Graduate School authorization for admission as a doctoral Candidate. Graduate Standing. (8; 4 in the half-term). (INDEPENDENT). May be repeated for credit.; Graduate School authorization for admission as a doctoral Candidate. N.B. The defense of the dissertation (the final oral examination) must be held under a full term Candidacy enrollment period.

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