Chemistry

1500 Chemistry
647-2858
Web site: http://www.umich.edu/~michchem/

Professor Joseph P. Marino, Chair

May be elected as a departmental concentration program in Chemistry and an interdepartmental concentration program in Biochemistry


Professors

Arthur J. Ashe, III, Organometallic Chemistry of Main-Group Elements
John Barker, Chemical Kinetics, Atmospheric Chemistry
Gene H. Cordes, Molecular Design; Enzymatic Reaction Mechanisms; Biochemistry
Dimitri Coucouvanis, Synthesis, Structures and Reactivities of Metal Clusters
James K. Coward, Bioorganic and Medicinal Chemistry; Organic chemistry related to biological reactions; mechanism of enzyme-catalyzed reactions; synthesis and enzymology of mechanism-based enzyme inhibitors
M. David Curtis, Organometallic Chemistry; Organometallic Polymers, Heterogeneous and Homogeneous Catalysis
Thomas M. Dunn, Optical spectroscopy of large (benzoid and fused ring systems) and small (mainly heterogeneous di- and triatomic) molecules; R2PI jet spectra of condensed ring aromatic molecules and the study of conformers and their possible interconversion
Seyhan N. Ege, Heterocyclic Reactive Intermediaries
Billy Joe Evans, Solid State Chemistry: Electronic and Magnetic Materials
Anthony H. Francis, Magnetic Resonance, Vibrational and Electronic Spectroscopy of Solids
John L. Gland, Solid State and Surface Chemistry, Physical Chemistry
Adon A. Gordus, Radioanalytical-Radiation Chemistry
Henry C. Griffin, Hot and Cold Nuclei; Nuclear Chemistry
Raoul Kopelman, Analytical/Biophysical/ Materials Chemistry Laser Spectroscopy, Nano-Imaging and Fiber Optic Chemical Nano-Sensors; Molecular Optics; Fractal Reaction Kinetics
Masato Koreeda, Natural Product Synthesis and Bioorganic Mechanisms
R.L. Kuczkowski, Molecular Spectroscopy of Weakly Bonded Complexes
Richard G. Lawton, Bioorganic Reagents as Chemical Probes of Molecular Architecture
Lawrence L. Lohr, Theoretical Studies of Molecular Structure and Reactivity
David Lubman, Biological Mass Spectrometry, Spectroscopy and Instrumentation
Joseph P. Marino, New Synthetic Methods and Strategies for Natural Product Synthesis
Mark E. Meyerhoff, Membrane Electrodes, Gas Sensors, Analytical Applications of Immobilized Bio-reagents, Enzyme-linked Competitive Binding Assays, New Stationary Phases for Liquid Chromatography
Michael D. Morris, Analytical Laser Spectroscopy and Imaging; Electrophoretic Separations
William H. Pearson, New Synthesis Methodology for the Assembly of Organic Molecules
Vincent L. Pecoraro, Synthetic Inorganic and Bioinorganic Chemistry
James Penner-Hahn, Biophysical Chemistry and Inorganic Spectroscopy. Investigation of Metal Site Structure in Bioinorganic Systems; X-ray, EPR and NMR Spectroscopy of Proteins
Paul G. Rasmussen, Polymer/Inorganic Chemistry
William R. Roush, Organic Chemistry
Richard D. Sacks, High Speed Analytical Separations
Robert R. Sharp, Multidimensional and Multiquantum NMR of Paramagnetic Systems
Leroy B. Townsend, Design and Synthesis of Heterocycles and Nucleosides
John R. Wiseman, Synthetic Organic Chemistry and Mechanisms of Chemical Reactions
Charles F. Yocum, Biological Chemistry of Photosynthetic Water Oxidation
Erik R.P. Zuiderweg, Structure and Dynamics of biomolecules and Complexes of Biomolecules in Solution, Using Multi-Dimensional Multi-Nuclear NMR Spectroscopy


Associate Professors

Mary Anne Carroll, Atmospheric Chemistry: Instrument development and application to field measurements of reactive nitrogen species
Gary D. Glick, Bioorganic Chemistry, Molecular Recognition
Richard M. Laine, Materials Chemistry
Stephen Lee, Synthesis, Structure and Electronic Structure of Extended Solids
Edward T. Zellers, Microfabricated chemical sensors; interfacial chemistry; polymer-solvent interactions; occupational/ environmental exposure assessment.


Assistant Professors

Mark M. Banaszak Holl, Synthetic and Mechanistic Solution, Surface, and Solid State Chemistry
Christine E. Evans, Analytical/Physical Chemistry; Separation Science; Interfacial Chemistry; Laser Spectroscopy
Richard A. Goldstein, Protein Design and Structure
E. Neil G. Marsh, Enzymes: structure mechanism and specificity; protein engineering and molecular recognition
Coleen Pugh, Polymer Synthesis, Liquid Crystals
Ayyalusamy Ramamoorthy, Solid-State NMR Spectroscopy, Structural Biology of Membrane Proteins, Study of Polymers
Roseanne Sension, Ultrafast Laser Spectroscopy and Chemical Reaction Dynamics
Peter L. Toogood, Bioorganic Chemistry


Lecturers

Brian P. Coppola, Organic chemistry, chemical education
Nancy Konigsberg Kerner, General chemistry, chemical education
Barbara J. Weathers, Inorganic chemistry, general chemistry


Professors Emeriti

Lawrence S. Bartell, S.M. Blinder, Daniel T. Longone, Christer E. Nordman, J. Lawrence Oncley, Charles G. Overberger, Charles L. Rulfs, Peter A.S. Smith, Milton Tamres, Robert C. Taylor, Edgar F. Westrum, Jr.


The curricula in Chemistry serve those preparing for careers in chemistry, biochemistry, medicine, chemical engineering, pharmacy, and allied fields as well as those seeking a general knowledge of chemistry as part of a liberal arts education. Beyond the first-year courses, there is an emphasis on development of technical knowledge and laboratory experience needed in chemistry and related scientific fields. The undergraduate concentration programs prepare students for work in research and testing laboratories, as well as for business positions in which a chemistry background is desirable. Graduate work is necessary for those planning to do college and university teaching or industrial research.

Introductory Courses. The Chemistry Department has three types of courses available to students starting toward careers in any of the sciences, engineering or medicine. Students are placed into these courses according to the results of the tests in chemistry and mathematics that they take during orientation. Either Chemistry 130 or Chemistry 210/211 can be the starting point for students interested in the sciences, engineering or medicine. Chemistry 130 has a section reserved for students who would benefit from more frequent contact with faculty. Honors students, students with Advanced Placement in chemistry, and other students with good preparation in high school chemistry have the opportunity to start their study in chemistry with courses 210/211, which introduce the major concepts of chemistry in the context of organic chemistry. This curriculum allows students to progress more rapidly to advanced courses in chemistry and to be able to participate earlier in undergraduate research.

Special Departmental Policies. The Department requires that a student earn a grade of at least C- in all chemistry courses which are prerequisite for subsequent elections. A concentration program grade point average of at least 2.0 is required; this includes chemistry courses, mathematics and physics prerequisites and advanced electives which are part of a concentration plan. Students must request any change in a grade before the end of the next regular academic term.

Safety Regulations. No contact lenses will be allowed in any chemistry laboratory. In laboratory classes students must wear either prescription or safety glasses at all times.

Student Associations. Chemistry concentrators are eligible to become student affiliates of the American Chemical Society. An active chapter exists in the Chemistry Department and provides opportunities for a variety of activities related to chemistry. In addition, Alpha Chi Sigma fraternity maintains a chapter house near campus. Men and women concentrating in chemistry, chemical engineering, and other related fields are eligible for membership.

Phi Lambda Upsilon, an honorary chemical society, maintains a chapter at the University of Michigan. Its members have achieved academic excellence in chemistry, chemical engineering, or pharmacy.

Concentration Program Options. The Department of Chemistry offers programs leading to a (1) Bachelor of Science degree with a concentration in chemistry (B.S. degree, 120 credits); (2) Bachelor of Science in Chemistry degree (B.S. Chem. degree, 124 credits); (3) a B.S. Chem. degree with Honors in chemistry. The Bachelor of Science in Chemistry (B.S. Chem.) degree requires a more rigorous and more specialized program of study. The program leading to Honors in chemistry is available to qualified students. (4) The department participates in and administers an interdepartmental concentration "Biochemistry." It is possible to incorporate a teaching certificate into any of these program options. In addition there is a five year joint degree program with the College of Engineering which leads to a B.S. Chem. and a Bachelor of Science in Engineering (Chemical Engineering). Information about the program leading to the joint degree with the College of Engineering and general information about teaching certificate requirements are described elsewhere in this Bulletin; departmental requirements for these programs are described below. It is strongly recommended that students who are thinking of degrees in chemistry stop by Room 1500 Chemistry to talk to a chemistry advisor as soon as possible, preferably before the end of the freshman year but certainly before the end of the sophomore year.


Chemistry (B.S. or B.S. Chem)

Prerequisites to Concentration for Either Program. Chemistry courses through 215, 216, 241/242, and 260; Physics 140/141 and 240/241; and Mathematics 115, 116, 215, 216, or an equivalent sequence are required for any concentration program in Chemistry. Physics 240 and Mathematics 215 are prerequisites for Chemistry 461 and students should, wherever possible, complete both of these before the junior year. The language requirement in Chemistry is satisfied by the College language requirement. A reading knowledge of German is recommended.

Bachelor of Science degree with a concentration in chemistry (120 credits). Students can complete the B.S. degree with a concentration in chemistry (120 credits) by taking Chemistry 302/312, 402, 447, 461, 462, 463, 480, and 485. Two credits of research (399) culminating in a written report may be substituted for the projects lab, 485.

Bachelor of Science in Chemistry (B.S. Chem.) (124 credits). The curriculum leading to a Bachelor of Science in Chemistry (B.S. Chem. degree) serves students who are interested in professional careers in chemistry, biochemistry, or related fields. Requirements include Chemistry 302/312, 402, 447, 461, 462, 463, 480, and four credits of Chemistry 399 taken over at least two terms, as well as one advanced lecture course in chemistry.

Honors Concentration in Chemistry. The B.S. Chem. degree is the basis of the Honors degree in Chemistry. Substitution of Honors sections of 461 and 463, maintenance of a satisfactory GPA (3.3) in concentration courses including prerequisites, and satisfactory completion of an Honors thesis (Chemistry 499) based on the research done in Chemistry 399 are required for Honors. Most (but not all) students pursuing the Honors degree will have participated in the Freshman-Sophomore College Honors Program and will have completed Chemistry 210, 211, 215, 216 in place of other concentration prerequisite courses. All students, whatever their program, who are interested in an Honors degree should see the Chemistry Honors Advisor (Room 1500 Chemistry) for approval for participation in the Junior-Senior Honors Program in Chemistry.

Advising. Students develop a concentration plan in consultation with a program advisor. Those interested in a B.S. degree with a concentration in chemistry (120 credits) or the specialized program leading to the Bachelor of Science in Chemistry (124 credits) are urged to consult a program advisor during the freshman and/or sophomore years. Prospective concentrators are advised that further study in chemistry requires adequate performance in early chemistry courses (preferably B- or better) as well as in the mathematics and physics prerequisites. Students interested in an Honors degree should see the Chemistry Honors advisor. Appointments are scheduled at the Chemistry Advising Office (1500 Chemistry, 647-2858). Students interested in the joint program with the College of Engineering should make an appointment with Chalmers Knight or Marge Carter (Academic Advising Center, 1255 Angell Hall, 764-0332) and then make an appointment to see a chemistry concentration advisor in 1500 Chemistry.

Teaching Certificate. Those seeking a B.S. or B.S. Chem. degree with a teaching certificate in Chemistry must fulfill departmental as well as School of Education requirements. Students who plan to earn a teaching certificate with a major or minor in Chemistry should contact the School of Education Office of Academic Services.


Biochemistry (B.S.)

May be elected as an interdepartmental concentration program.

Prerequisites to Concentration. Biology 152 or Biology 195; Chemistry 210, 211, 215, 216; Mathematics 115, 116, 215, and 216 (or the equivalent); Physics 140/141 and 240/241. It is recommended that students interested in pursuing graduate work acquire a reading knowledge of French, German, or Russian. The prerequisite work in the basic sciences and in meeting the language requirement should be completed before the junior year.

Concentration Program. Must include Biology 305; Chemistry 241/242, 260, 302, 461/462 and 463 or 447; Chemistry 451 and 452; and an advanced laboratory or undergraduate research course. Recommended options for the advanced laboratory course are Biol. Chem. 416, Biology 429, Chemistry 480, or two terms (2 credits each) of an advanced undergraduate research project by permission of the concentration advisor. Students electing the undergraduate research option must execute an extended research project under the supervision of a faculty member who agrees to oversee the project.

Courses recommended, but not required are: One advanced Biol. Chem. 500-level module, Biology 427, 428, Chemistry 417 and 530. Requirements are flexible enough to accommodate a range of diverse interests in the physical, chemical, and biological sciences.

Honors Concentration. Qualified students may elect an Honors concentration. This program requires a thesis which describes and analyzes independent experimental work. The research topic and advisor must be approved by the Honors advisor in Biochemistry. Students in this program are expected to maintain an overall grade point average above 3.0 and at least a 3.3 in field of concentration, including prerequisite courses. Chem 398 (4 credits) and the thesis course, Chem 498, replaces the requirement for an upper-level laboratory course outlined above.

Advising. Appointments are scheduled in 1500 Chemistry (647-2857).


Courses in Chemistry (Division 334)

105/AOSS 105. Our Changing Atmosphere. (3). (NS). (BS).

106. Environmental Issues. (3). (NS). (BS).

108/Geol. 130/Phys. 119. The Physical World. High-school algebra. (4). (NS). (BS). (QR/2).

125. General and Inorganic Chemistry: Laboratory. To be elected by students who are eligible for (or enrolled in) Chem. 130. No credit granted to those who have completed Chem. 211. (2). (NS). (BS). Laboratory fee ($60) required.

130. General Chemistry: Macroscopic Investigations and Reaction Principles. Three years of high school math or Math. 105; one year of high school chemistry recommended. Placement by testing, or permission of Chemistry department. Intended for students without AP credit in chemistry. (3). (NS). (BS). (QR/2).

210. Structure and Reactivity I. High school chemistry. Placement by examination during Orientation. To be taken with Chem. 211. (4). (NS). (BS).

211. Investigations in Chemistry. To be taken with Chem. 210. (1). (NS). (BS). Laboratory fee ($67.50) required.

215. Structure and Reactivity II. Chem. 210, 211. To be taken with Chem. 216. (3). (NS). (BS).

216. Synthesis and Characterization of Organic Compounds. Chem. 210, 211. Must be taken with Chem. 215. (2). (NS). (BS). Laboratory fee ($62.50) required.

218. Independent Study in Biochemistry. Permission of instructor. For students with less than junior standing. (1). (Excl). (INDEPENDENT). May be repeated for a total of 4 credits.

219. Independent Study in Chemistry. Permission of instructor. For students with less than junior standing. (1). (Excl). (INDEPENDENT). May be repeated for a total of 4 credits.

230. Physical Chemical Principles and Applications. Chem. 215. No credit granted to those who have completed or are enrolled in Chem. 260. No credit granted to those who have completed Chem 340. (3). (NS). (BS).

241. Introduction to Chemical Analysis. Prior or concurrent enrollment in Chem 260. No credit granted to those who have completed Chem. 340. (2). (NS). (BS).

242. Introduction to Chemical Analysis Laboratory. Prior or concurrent enrollment in Chem 260. No credit granted to those who have completed Chem. 340. (2). (NS). (BS). Laboratory fee ($50) required.

260. Chemical Principles. Chem. 215/216, Math 115, and prior or concurrent enrollment in Phys 140. No credit granted for students that have completed or are enrolled in Chemistry 260. No credit granted to those who have completed Chem. 340. (3). (NS). (BS).

261. Introduction to Quantum Chemistry. Chem. 215/216, Math 115, and prior or concurrent enrollment in Phys 140. Chem. 261 is intended primarily for Chemical Engineering students. No credit granted for students that have completed or are enrolled in Chemistry 260. No credit granted to students who have completed Chem. 340. (1). (Excl).

302. Inorganic Chemistry: Principles of Structure, Reactivity, and Function. Chem. 260 (or Chem. 261 and ChemE 330; or 340). (3). (NS). (BS).

312. Synthesis and Characterization. Chem. 215 and 216. Prior or concurrent enrollment in Chem. 302. (2). (Excl). (BS). Laboratory fee ($70) required.

365. Principles of Physical Chemistry. Two terms of chemistry; Physics 140 or 160, and 141; and prior or concurrent enrollment in Math. 215 or 285. (4). (Excl). (BS).

398. Undergraduate Research in Biochemistry. Junior standing, and permission of a biochemistry concentration advisor and the professor who will supervise the research. (1-4). (Excl). (INDEPENDENT). May be elected for a total of 4 credits during junior or senior year.

399. Undergraduate Research. Junior standing, and permission of a chemistry concentration advisor and the professor who will supervise the research. (1-4). (Excl). (INDEPENDENT). May be elected for a total of 4 credits during junior or senior year.

400. Philosophy, Principles and Practice for Chemical Science Teachers: Integrating the Precollegiate Lecture and Laboratory. Chem. 130. (2). (Excl). May not be included in a concentration plan in chemistry.

401. Philosophy, Principles and Practice for Chemical Science Teachers: Curriculum Enrichment for Precollegiate Chemistry. Chem. 130. May not be included in a concentration plan in chemistry. (2). (Excl). Laboratory fee ($50) required.

402. Intermediate Inorganic Chemistry. Chem. 302, and 461/462 (or 469). (3). (Excl). (BS).

417/Physics 417. Dynamical Processes in Biophysics. Math. 216, and Phys. 340 or Chem. 463 (or 468). (3). (Excl). (BS).

420. Intermediate Organic Chemistry. Chem. 215 and 216. (3). (Excl). (BS).

436. Polymer Synthesis and Characterization. Chem. 340. (3). (Excl). (BS). Laboratory fee ($50) required.

447. Physical Methods of Analysis. Chem. 260 and 241/242 (or 340). (3). (Excl). (BS).

451. Introduction to Biochemistry I. Chem. 215, Biol. 152 or 195, and Math. 115. No credit granted to those who have completed or are enrolled in Biol. 311 or Biol. Chem. 415. (4). (Excl). (BS).

452. Introduction to Biochemistry II. Chem. 451. (4). (Excl). (BS).

461. Physical Chemistry I. Chemistry 260 (or 340), Physics 240, and Math. 215. No credit granted to those who have completed Chem. 397 or 469. (3). (Excl). (BS).

462. Computational Chemistry Laboratory. Math 215, and prior or concurrent enrollment in Chemistry 461. (1). (Excl). (BS).

463. Physical Chemistry II. Chemistry 461/462. No credit granted to those who have completed Chem. 396 or 468. (3). (Excl). (BS).

467/AOSS 467/Geol. 465. Biogeochemical Cycles. Math. 116, Chem. 210, and Phys. 240. (3). (Excl). (BS).

479. Technical Communication in Chemistry. Concurrent enrollment in Chem. 480. (1). (Excl). (BS).

480. Physical and Instrumental Chemistry. Chem. 447 and 461/462; and concurrent enrollment in Chem. 463. (3). (Excl). (BS). Laboratory fee ($50) required.

485. Projects Laboratory. Chem. 480. (2). (Excl). (BS). Laboratory fee ($50) required.

495. Professional Development in the Chemical Sciences. Chem. 461. (2). (Excl). Meets ECB Junior/Senior Writing requirement.

498. Undergraduate Honors Thesis in Biochemistry. Chem. 398 and permission of instructor. To be elected in the term in which an Honors student presents a thesis on undergraduate research. (1). (Excl). (INDEPENDENT).

499. Undergraduate Thesis. Chem. 399 and permission of instructor. To be elected in the term in which an Honors student presents a thesis on undergraduate research. (1). (Excl). (INDEPENDENT).

507. Inorganic Chemistry. Chem. 461 (or 469 or 397). (3). (Excl). (BS).

510(Biophysics 610)/Biophysics 510. Biophysical Chemistry I. Chem. 463, Biol. Chem. 415, or Chem 420; permission of course director. (3). (Excl).

511/Biophysics 511. Biophysical Chemistry II. Chem. 461, Biol. Chem. 415, and Chem. 430; and permission of course director. (3). (Excl).

530. Introduction to Bioorganic Mechanisms. Chem. 215 and 216, and Chem. 340. (3). (Excl). (BS).

535/Macromolecular Science 535. Physical Chemistry of Macromolecules. Chem. 463 (or 468). (3). (Excl). (BS).

536/Macromolecular Science 536. Laboratory in Macromolecular Chemistry. Chem. 535 or Phys. 418. (2). (Excl). (BS). Laboratory fee ($50) required.

538/Macromolecular Science 538. Organic Chemistry of Macromolecules. Chem. 215/216 and Chem. 230 or 340. (3). (Excl). (BS).

540. Organic Principles. Chem. 312 and 461. (3). (Excl). (BS).

541. Advanced Organic Chemistry. Chem. 540. (3). (Excl). (BS).

542. Applications of Physical Methods to Organic Chemistry. Chem. 260, 241/242, and 312. (3). (Excl). (BS).

567/AOSS 567. Chemical Kinetics. Chem. 461 (or 469) or AOSS 479. (3). (Excl). (BS).

570. Molecular Physical Chemistry. Chem. 461 and 463 (or 468/469). (3). (Excl). (BS).

575. Chemical Thermodynamics. Chem. 461 (or 469). (3). (Excl). (BS).

580. Molecular Spectra and Structure. Chem. 570. (3). (Excl). (BS).


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