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LSA Course Guide Search Results: UG, GR, Fall 2007, Dept = BIOPHYS
 
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Title
Section
Instructor
Term
Credits
Requirements
BIOPHYS 120 — In the Footsteps of Watson and Crick
Section 001, SEM

FA 2007
Credits: 3
Reqs: BS

This course introduces students to biophysics and its role in the life sciences. The historical example of the discovery of the structure of DNA by Watson and Crick is discussed and re-created using modern techniques. As a highlight, the structure of a DNA crystal will determined using the synchrotron at the Argonne National Laboratory. Students will compose a term paper that critically compares the historical and the modern techniques at each step of the structure determination.

Intended audience: First-year students interested in the natural sciences and medicine.

Course Requirements: Student presentations, quizzes, and a term paper.

Class Format: Class will meet twice for 3 hours per week in a lecture/discussion format plus a 2 hpw laboratory. In addition, a field trip to the Argonne National Laboratory is planned.

BIOPHYS 501 — Chemical Biology I
Section 001, SEM

Instructor: Saper,Mark A; homepage

FA 2007
Credits: 3
Reqs: BS

This course will provide a high-level overview on the structure, function and chemistry of biological macromolecules including proteins, nucleic acids and carbohydrates. Topics include protein and nucleic acid folding, energetics of macromolecular interactions (kinetics and thermodynamics), and mechanistic enzymology. Using specific examples from the current literature, each topic will stress how chemists have used molecular level tools and probes to help understand the specific systems under study. The over arching theme in this course will be that structure and function are intimately linked.

BIOPHYS 520 — Biophysical Chemistry I
Section 001, LEC

Instructor: Zuiderweg,Erik R P; homepage

FA 2007
Credits: 3
Reqs: BS

This course is the first of a two-term Biophysical Chemistry series BIOPHYS 520/521, but it can be taken as stand-alone course as well. BIOPHYS 520 will introduce and explain the physicochemical properties of biological macromolecules and their complexes, mostly in solution. The course offers an overview of protein and nucleic acid structures. Intra- and inter-molecular forces, helix-coil transitions, and protein folding will be treated in a thermodynamical context.

Thermodynamics of solutions, configurational statistics, ligand interactions, multi-site interactions, and cooperativity are treated in depth. Kinetics and thermodynamics of protein-ligand binding are discussed. The role of dynamics in protein function is introduced.

Currently, biophysical, biochemical, and pharmacochemical research literature is full with papers interpreting the properties of biological macromolecules on the basis of their three-dimensional structure. This course will expand on that concept by offering a rigorous background in energetics, folding, interactions, and dynamics. As such the course is important to any student who has to deal with the concepts of biomolecular function and structure such as biochemists, molecular biophysicists, mathematical biologists, and molecular pharmacologists. This course will also serve as a basis for the graduate student who will be specializing in any of these topics for thesis research.

Instructional material: Van Holde, Physical Biochemistry, 1998 and course packs.

Evaluation: homework (40%), midterm exam (30%) and final exam (30%).

Advisory Prerequisite: PHYSICS,CHEM 420/463, BIOLCHEM 415/permission of instructor

BIOPHYS 801 — Seminar by Molecular Biophysics Trainees
Section 001, SEM

Instructor: Penner-Hahn,James E; homepage

FA 2007
Credits: 1

Students in Molecular Biophysics fulfill the requirements for a Ph.D. in either Biological Chemistry, Biophysics, Chemistry, or Physics. Training in Molecular Biophysics aims to develop independent investigators who will contribute in significant ways to advances in understanding structural and cellular biology at the molecular level. Students concentrating in Molecular Biophysics elect courses in areas such as protein structure and function, techniques in NMR and crystallography, and spectroscopic methods.

Advisory Prerequisite: Graduate standing and permission of instructor.

BIOPHYS 890 — Introduction to Research
Section 001, IND

FA 2007
Credits: 1 — 4

The main focus is to offer research training in the applications of physics-based techniques to biological systems ranging in complexity from single molecules to whole cells and tissues.

Advisory Prerequisite: PHYSICS,Research rotations: Primarily for students in the Biophysics Graduate Program. Graduate standing and permission of instructor.

BIOPHYS 990 — Dissertation/Precandidate
Section 001, IND

FA 2007
Credits: 1 — 8

Election for dissertation work by doctoral student not yet admitted as a Candidate.

Advisory Prerequisite: Election for dissertation work by doctoral student not yet admitted as a Candidate. Graduate standing.

BIOPHYS 995 — Dissertation/Candidate
Section 001, IND

FA 2007
Credits: 8

Graduate School authorization for admission as a doctoral Candidate. N.B. The defense of the dissertation (the final oral examination) must be held under a full term Candidacy enrollment period.

Enforced Prerequisites: Graduate School authorization for admission as a doctoral Candidate

 
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