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Fall Academic Term 2002 Course Guide

Note: You must establish a session for Fall Academic Term 2002 on wolverineaccess.umich.edu in order to use the link "Check Times, Location, and Availability". Once your session is established, the links will function.

Courses in Molecular, Cellular, and Developmental Biology


This page was created at 7:54 PM on Thu, Oct 3, 2002.

Fall Academic Term, 2002 (September 3 - December 20)


The Department formerly known as Biology divided into two separate departments, EEB (Ecology and Evolutionary Biology) and MCDB (Molecular, Cellular and Developmental Biology). The Interdepartmental Program in Biology (BIOLOGY) is administered jointly by the Department of Ecology and Evolutionary Biology (EEB) and the Department of Molecular, Cellular, and Developmental Biology (MCDB).

The concentration programs remain the same; however, there some changes in how courses are listed starting this fall term. 100 and 220 - level courses are listed under the subject of BIOLOGY, as are some of the core concentration courses such as Genetics, Biochemistry, and Evolution. Intermediate and upper level courses are listed under EEB or MCDB, depending on the course topics. Students must look under the three subjects to see whether or not a course is being offered.

Those students planning to register for independent research, 300 or 400, will enroll in either MCDB 300 or 400 or EEB 300 or 400, based on their faculty sponsor's departmental affiliation.

Courses in Molecular, Cellular and Developmental Biology

Courses in Ecology and Evolutionary Biology

Courses in the Program in Biology

The undergraduate curriculum aims to convey the excitement generated by recent research findings, and to offer hands-on research opportunities to many of our students. The Department offers a large number of courses for undergraduate students, including a variety of designed for nonscience majors.

The Department of Molecular Cellular and Developmental Biology (MCDB) is one of two new departments which have been formed from the restructuring of the Biology Department.

Current areas of focus are:

  1. biochemistry and microbiology
  2. cell biology
  3. developmental biology
  4. molecular evolution
  5. neurobiology and physiology
  6. plant molecular biology


MCDB 300(BIOLOGY 300). Undergraduate Research.

Instructor(s):

Prerequisites & Distribution: Eight credits of biology and 3.0 grade point average in science; permission of faculty member in biology. (1-3). (Excl). (BS). (INDEPENDENT). May be repeated for a total of 9 credits.

Credits: (1-3).

Course Homepage: No homepage submitted.

MCBD 300 intended primarily for juniors, including Honors students, who wish to pursue independent research or study at an intermediate level in an area of biological science. Students may ask an appropriate faculty member in the Department of Biology to direct the research project and supervise related readings. The project may take the form of an investigation of new problems in the field or laboratory, a detailed investigation of primary sources (a literature survey), development of new procedures or programs, design of a classroom experiment, etc. A final paper is required and must be approved by the research advisor.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of Department

MCDB 302(BIOLOGY 302). Teaching Experience for Undergraduates.

Instructor(s):

Prerequisites & Distribution: Permission of instructor. (1-3). (Excl). May not be included in any of the Biological Sciences concentration programs. (EXPERIENTIAL).

Credits: (1-3).

Course Homepage: No homepage submitted.

Undergraduates participating in this course are responsible for:

  1. aiding regularly assigned Graduate Student Instructors;
  2. providing tutorial help for undergraduates enrolled in the course;
  3. meeting regularly with discussion and laboratory sessions; and
  4. participating with Graduate Student Instructors in instructional activities.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of Department

MCDB 306(BIOLOGY 306). Introductory Genetics Laboratory.

Section 001.

Instructor(s): Santhadevi Jeyabalan (sjeyabal@umich.edu)

Prerequisites & Distribution: Prior or concurrent enrollment in BIOLOGY 305. (3). (Excl). (BS). Satisfies a Biology laboratory requirement. Laboratory fee ($70) required.

Credits: (3).

Lab Fee: Laboratory fee ($70) required.

Course Homepage: http://biology.lsa.umich.edu/~www/bio306/

This course provides students with laboratory experience on basic genetic principles. Students will analyze patterns of inheritance, gene interaction, linkage relationship, and genetic mapping of unknown mutants of Drosophila through a series of genetic crosses. By using molecular techniques such as Polymerase Chain Reaction (PCR) and gel electrophoresis, mutations in Caenorhabditis elegans will be mapped to chromosomal locations. The experiments in microbial genetics include mapping by conjugation in E. coli, recombination analysis by transduction using bacteria and phage, and complementation tests on "his" mutants of yeast. Experiments in Human Population Genetics include calculating allelic frequencies of PTC tasting in the class.

Students will also be doing DNA fingerprinting of a VNTR locus using their own squamous epithelial cells. One hour lecture on Mondays 1-2 PM and one three-hour lab are scheduled each week; additional 3-4 hours of lab time per week is expected at irregular times. Students are expected to write one formal lab report and to keep a complete and accurate record of all results and analyses in a bound lab notebook. There are two tests given during the term. Students will need to purchase a lab manual from Grade A Notes.

Check Times, Location, and Availability Cost: 1 Waitlist Code: 1

MCDB 324(BIOLOGY 324/224). Biology of Cancer.

Section 001.

Instructor(s): Lewis J Kleinsmith (lewisk@umich.edu)

Prerequisites & Distribution: BIOLOGY 162. No credit granted to those who have completed or are enrolled in BIOLOGY 124. (3). (NS). (BS).

Credits: (3).

Course Homepage: No homepage submitted.

The Biology of Cancer is a lecture/discussion course designed to provide students with a basic understanding of the biological events associated with the development of cancer. This course is organized around three fundamental questions: What is cancer; what are the causes of cancer; and can cancer be cured or prevented? Lectures will include descriptions of classical and recent experiments which address these questions, and will also provide students with the vocabulary and background needed to critically read and evaluate technical literature dealing with the subject of cancer. Periodic reading assignments from the textbook and course pack will be used to supplement lecture and discussion topics. Student performance will be evaluated by a combination of three exams and a term paper based upon library research. In order to provide the time required for this library research, the lecture-discussion meetings will be dismissed for approximately one week late in the term. The class will meet twice a week for an hour and a half lecture, and a weekly hour and a half discussion session will also be held. Textbook: How to Lie with Statistics by Darrell Huff. A course pack is also required.

Check Times, Location, and Availability Cost: 1 Waitlist Code: 1

MCDB 400(BIOLOGY 400). Advanced Research.

Instructor(s):

Prerequisites & Distribution: 12 credits of biology, 3.0 average in science, and permission of faculty member in biology. (1-3). (Excl). (BS). (INDEPENDENT). May be repeated for a total of 9 credits.

Credits: (1-3).

Course Homepage: No homepage submitted.

Intended for those engaged in original research at an advanced level. This course number is most frequently elected by senior Honors students who have completed MCDB 300 and who are completing their research and writing their thesis. A final paper is required. (Refer to the description of MCDB 300 for more information.)

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of Department

MCDB 411(BIOLOGY 411). Protein Structure and Function.

Section 001.

Instructor(s): James Bardwell (jbardwel@umich.edu)

Prerequisites & Distribution: BIOLOGY 310, 311, or BIOLCHEM 415. (3). (Excl). (BS).

Credits: (3).

Course Homepage: http://www.biology.lsa.umich.edu/courses/bio411/

A taste of bioinformatics. This course is a practical hands-on approach to extract information about protein and DNA sequences. Students will learn how to do elementary sequence analysis databases, searching, alignment, and 3D-structure prediction using analysis tools that are available on the web. Students will learn how to get the most out of their sequence. We will also discuss how protein structure is related to function, and investigate how proteins fold.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

MCDB 412(BIOLOGY 412). Teaching Biochemistry by the Keller Plan.

Section 001.

Instructor(s): Kenneth J Balazovich

Prerequisites & Distribution: BIOLOGY 311 and permission of instructor. (3). (Excl). May not be included in any of the Biological Sciences concentration programs. (EXPERIENTIAL).

Credits: (3).

Course Homepage: No homepage submitted.

Undergraduates who previously have taken an introductory biochemistry course act as TAs for Introductory Biochemistry (Biology 311). TAs meet with the instructor for a two-hour class each week for lectures, presentations, and discussions of teaching and biochemistry. TAs also prepare a report on a recent advance in biochemistry which they present to their peers and the instructor. The major roles of the TAs are to examine the students on their mastery of unit material and to help the students with explanations supplementary to the textbook. At the completion of an instructor-generated written quiz, the student and TA grade the quiz together. TAs learn considerable biochemistry by repeated teachings of unit materials and, in addition, profit from their experience as teachers and evaluators.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of Instructor

MCDB 418(BIOLOGY 418). Endocrinology.

Section 001.

Instructor(s): Robert J Denver (rdenver@umich.edu)

Prerequisites & Distribution: BIOLOGY 162, 225, and organic chemistry. (3). (Excl). (BS).

Credits: (3).

Course Homepage: http://www.biology.lsa.umich.edu/courses/bio418/bio418.htm

This course is a comparative study of animal endocrine functions with emphasis on the cellular origin and chemical nature of hormones, the cellular and molecular mechanisms of hormone action, general endocrine control mechanisms, the evolution of hormones and hormonal control and their physiological actions in animals. The course will concentrate on the endocrine systems of vertebrates; there will be limited treatment of human endocrinology. Instruction in BIOLOGY 418 assumes a basic familiarity with general and comparative physiology. Training in chemistry through organic is essential, and courses in biochemistry and cell and molecular biology are helpful.

Textbook: Vertebrate Endocrinology. 3rd. edition. D.O. Norris.

Check Times, Location, and Availability Cost: 2 Waitlist Code: 1

MCDB 419(BIOLOGY 419). Endocrinology Laboratory.

Section 001.

Instructor(s): Sushama Denver (spavgi@umich.edu)

Prerequisites & Distribution: Prior or concurrent enrollment in BIOLOGY 225 or 310 or 311, or MCDB 418 or 426. (3). (Excl). (BS). Satisfies a Biology laboratory requirement. Laboratory fee ($70) required.

Credits: (3).

Lab Fee: Laboratory fee ($70) required.

Course Homepage: No homepage submitted.

This laboratory course provides hands-on experience with methods used in endocrinological investigations. The students will learn techniques ranging from the organismal to the molecular level. The course emphasizes hypothesis testing, modern techniques, and data analysis. Prior or concurrent enrollment in BIOLOGY 418 is required to take this course. The enrollment is limited to 12 students. Students should be aware that this course uses live animals. The laboratory will meet twice a week (a four-hour session and a two-hour session), however, students should anticipate an additional two or three hours laboratory time at various (and occasionally odd) times in the week. Course assignments include a term paper, quizzes, and other short assignments.

Check Times, Location, and Availability Cost: 1 Waitlist Code: 1

MCDB 422(BIOLOGY 422) / ANAT 422. Cellular and Molecular Neurobiology.

Section 001.

Instructor(s): John Y Kuwada (kuwada@umich.edu), Bruce Oakley (boakley@umich.edu)

Prerequisites & Distribution: BIOLOGY 162, one year of physics, prior or concurrent enrollment in biochemistry. (3). (Excl). (BS).

Credits: (3).

Course Homepage: No homepage submitted.

This course deals primarily with the properties of individual nerve cells, and small groups of nerve cells. This provides the basis for understanding information processing by the nervous system, learning and memory, development of neurons, and neurological and psychiatric disorders. Considerable emphasis will be placed on understanding the molecules that endow the nervous system with these properties.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 1

MCDB 423(BIOLOGY 423). Introduction to Research in Cellular and Molecular Neurobiology.

Section 001.

Instructor(s): Richard I Hume (rhume@umich.edu)

Prerequisites & Distribution: Concurrent enrollment in MCDB 422; or completion of BIOLOGY 222 or MCDB 422, and permission of instructor. (3). (Excl). (BS). Satisfies a Biology laboratory requirement. Laboratory fee ($70) required.

Credits: (3).

Lab Fee: Laboratory fee ($70) required.

Course Homepage: http://www.biology.lsa.umich.edu/~www/bio423/bio423syl.htm

This lab course provides an introduction to experimental approaches in neurobiology. Emphasis is on molecular, anatomical, and physiological approaches for studying neuronal function. Among the molecular topics to be covered are analysis of cDNA clones, PCR amplification of DNA, and expression of genes in foreign tissues. Among the anatomical topics to be covered are gross and microscopic anatomy of nervous systems, axonal pathway tracing, and immunocytochemical localization of specific neuronal proteins. Among the physiological topics to be covered are intracellular and extracellular recording, as well as the use of computers in the acquisition and analysis of data. This course is intended for students who plan to engage in research in neurobiology. A course pack is required.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of Instructor

MCDB 427(BIOLOGY 427). Molecular Biology.

Section 001.

Instructor(s): Rolf Andre Bodmer (rolf@umich.edu), Jianming Li (jian@umich.edu)

Prerequisites & Distribution: BIOLOGY 305; and BIOLOGY 310 or 311, or BIOLCHEM 415. (4). (Excl). (BS).

Credits: (4).

Course Homepage: http://www.biology.lsa.umich.edu/courses/MCDB427/

Comprehensive coverage of the general principles governing the structures, synthesis, and functions of DNA, RNA, and proteins in the context of the cell. Emphasizes understanding methods and interpretation of data. Topics include genome organization, DNA replication and transposition, chromosome segregation, transcription and translation, the processing of macromolecules, signal transfer, and regulation at various levels. Two lectures per week are supplemented by a 1.5 hour discusssion section.

Check Times, Location, and Availability Cost: 3 Waitlist Code: 1

MCDB 521(BIOLOGY 521). Bacterial Physiology II: Carbon Metabolism.

Section 001 THIS COURSE WILL MEET OCT. 8 - NOV. 5. (Drop/Add deadline=October 14).

Instructor(s): Robert A Bender (rbender@umich.edu)

Prerequisites & Distribution: BIOLOGY 305, and BIOLOGY 310 or 311 or BIOLCHEM 415. (1). (Excl). (BS).

Mini/Short course

Credits: (1).

Course Homepage: http://www.biology.lsa.umich.edu/courses/bio521/home.htm.

This course will focus on central metabolism especially the catabolism of glucose, lactose, and amino acids. Among the topics considered will be: (1) "The memory paradox" where bacterial cells remember how they were grown 40 generations ago in the absence of external reminder; (2) the integration of pathways and how changes in one effect the flow of another; and (3) global regulators (known and unknown) that integrate complex signals and transmit them into gene expression responses. Biochemistry shows that pathways exist, physiology asks the questions of how they function and why they are important. The key theme of the course will be regulation rather than memorizing pathways.

Bacterial Physiology II is entirely independent of the related Bacterial Physiology I and III courses and can be taken without either of the others.

Check Times, Location, and Availability Cost: 1 Waitlist Code: No Data Given.

MCDB 522(BIOLOGY 522). Bacterial Physiology III: Nitrogen Metabolism.

Section 001 THIS COURSE WILL MEET NOV. 7 - DEC. 10. (Drop/Add deadline=November 13).

Instructor(s): Robert A Bender (rbender@umich.edu)

Prerequisites & Distribution: BIOLOGY 305, and BIOLOGY 310, 311, or BIOLCHEM 415. (1). (Excl). (BS).

Mini/Short course

Credits: (1).

Course Homepage: http://www.biology.lsa.umich.edu/courses/bio522/home.htm

This course will focus on the interconversion of various kinds of nitrogen sources. Topics will include the reduction of nitrate and atmospheric nitrogen to ammonia and the catabolism of urea and amino acids. Emphasis will be on the regulation of these pathways and the regulatory features that allow cells to use only the "appropriate" nitrogen sources to supply their needs. For example, how does a cell know to use the urea before porline as a nitrogen source (and ammonia before urea)? The key theme of the course will be regulation and the logical methods used to figure out how regulation functions.

Bacterial Physiology III is entirely independent of the related Bacterial Physiology I and II courses and can be taken without either of the others. The course is intended for graduate students and upper class undergraduates with an interest in microbiology or biochemical regulation.

Check Times, Location, and Availability Cost: 1 Waitlist Code: No Data Given.

MCDB 525(BIOLOGY 525) / CHEM 525. Chemical Biology I.

Section 100.

Instructor(s): Richard A Goldstein

Prerequisites & Distribution: CHEM 451, 452, 461, and 463. (3). (Excl). (BS).

Credits: (3).

Course Homepage: http://coursetools.ummu.umich.edu/2002/fall/chem/525/001.nsf

See Chemistry 525.001.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

Graduate Course Listings for MCDB.


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