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Fall Academic Term 2003 Course Guide

Note: You must establish a session for Fall Academic Term 2003 on wolverineaccess.umich.edu in order to use the link "Check Times, Location, and Availability". Once your session is established, the links will function.

Courses in Molecular, Cellular, and Developmental Biology


This page was created at 7:01 PM on Tue, Sep 23, 2003.

Fall Academic Term, 2003 (September 2 - December 19)


The Department formerly known as Biology divided into two separate departments, EEB (Ecology and Evolutionary Biology) and MCDB (Molecular, Cellular and Developmental Biology). The Interdepartmental Program in Biology (BIOLOGY) is administered jointly by the Department of Ecology and Evolutionary Biology (EEB) and the Department of Molecular, Cellular, and Developmental Biology (MCDB).

Beginning with the Fall 2002 term, there have been some changes in how courses are listed. 100 and 200-level courses are listed under the subject of BIOLOGY, as are some of the core concentration courses such as Genetics, Biochemistry, and Evolution. Intermediate and upper-level courses are listed under EEB or MCDB, depending on the course topics. Students must look under the three subjects to see whether or not a course is being offered.

Those students planning to register for independent research, 300 or 400, will enroll in either MCDB 300 or 400 or EEB 300 or 400, based on their faculty sponsor's departmental affiliation.

Courses in Biology

Courses in Ecology and Evolutionary Biology


MCDB 300(BIOLOGY 300). Undergraduate Research.

Instructor(s):

Prerequisites & Distribution: Eight credits of biology and 3.0 grade point average in science; permission of faculty member. (1-3). (Excl). (BS). (INDEPENDENT). May be repeated for credit for a maximum of 9 credits.

Credits: (1-3).

Course Homepage: No homepage submitted.

MCDB 300 is intended primarily for juniors, including Biology or CMB Honors students, who wish to pursue independent research at an intermediate level in an area of biological science. Students may ask an appropriate faculty member in the Department of Molecular Cellular and Developmental Biology to direct the research project and supervise related readings. Alternatively, students may identify a research advisor in another LS&A department, the UM Medical School, or another unit on the UM campus. Students conducting independent research in such outside units must identify a co-sponsor within the Department of MCDB. Independent research is defined as a laboratory project in which the student will have a say in the design, conduct, and interpretation of experiments. Library research projects and lab projects which are strictly a technical training experience do not qualify for credit as undergraduate research. A final paper is required and must be approved by the research advisor.

The work in this course may continue for two semesters. A 'Y' grade can be reported at the end of the first-term to indicate work in progress. At the end of the second term of MCDB 300, the final grade is posted for both term's elections. Students interested in MCDB 300 should obtain the brochure MCDB Department Policies on Undergraduate Research from the Undergraduate Biology Program Office (1111 Natural Science Bldg).

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of instructor required.

MCDB 302(BIOLOGY 302). Teaching Experience for Undergraduates.

Instructor(s):

Prerequisites & Distribution: Permission of instructor. (1-3). (Excl). (EXPERIENTIAL). May not be repeated for credit. May not be included in any of the Biological Sciences concentration programs.

Credits: (1-3).

Course Homepage: No homepage submitted.

No Description Provided. Contact the Department.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of instructor required.

MCDB 306(BIOLOGY 306). Introductory Genetics Laboratory.

Section 001.

Instructor(s): Santhadevi Jeyabalan (sjeyabal@umich.edu)

Prerequisites & Distribution: Prior or concurrent enrollment in BIOLOGY 305. (3). (Excl). (BS). May not be repeated for credit. Satisfies a Biology laboratory requirement. Laboratory fee ($70) required.

Credits: (3).

Lab Fee: Laboratory fee ($70) required.

Course Homepage: No homepage submitted.

This course provides students with laboratory experience on basic genetic principles. Students will analyze patterns of inheritance, gene interaction, linkage relationship, and genetic mapping of unknown mutants of Drosophila through a series of genetic crosses. By using molecular techniques such as Polymerase Chain Reaction (PCR) and gel electrophoresis, mutations in Caenorhabditis elegans will be mapped to chromosomal locations. The experiments in microbial genetics include mapping by conjugation in E. coli, recombination analysis by transduction using bacteria and phage, and complementation tests on "his" mutants of yeast. Experiments in Human Population Genetics include calculating allelic frequencies of PTC tasting in the class. Students will also be doing DNA fingerprinting of a VNTR locus using their own squamous epithelial cells. A computer exercise on Bioinformatics is included. One hour lecture on Mondays 1-2 PM and one three-hour lab are scheduled each week; additional 3-4 hours of lab time per week is expected at irregular times. Students are expected to write one formal lab report and to keep a complete and accurate record of all results and analyses in a bound lab notebook. There are two tests given during the term. Students will need to purchase from one of the copy centers, a lab manual, MCDB 306 Genetics Laboratory Manual, by Jeyabalan.

Check Times, Location, and Availability Cost: 1 Waitlist Code: 1

MCDB 324(BIOLOGY 324). Biology of Cancer.

Section 001.

Instructor(s): Lewis J Kleinsmith (lewisk@umich.edu)

Prerequisites & Distribution: BIOLOGY 162. (3). (NS). (BS). May not be repeated for credit. No credit granted to those who have completed or are enrolled in BIOLOGY 124.

Credits: (3).

Course Homepage: No homepage submitted.

The Biology of Cancer is a lecture/discussion course designed to provide students with a basic understanding of the biological events associated with the development of cancer. This course is organized around three fundamental questions:

  • What is cancer;
  • what are the causes of cancer; and
  • can cancer be cured or prevented?

Lectures will include descriptions of classical and recent experiments which address these questions, and will also provide students with the vocabulary and background needed to critically read and evaluate technical literature dealing with the subject of cancer. Periodic reading assignments from the textbook and course pack will be used to supplement lecture and discussion topics. Student performance will be evaluated by a combination of three exams and a term paper based upon library research. In order to provide the time required for this library research, the lecture-discussion meetings will be dismissed for approximately one week late in the term. The class will meet twice a week for an hour and a half lecture, and a weekly hour and a half discussion session will also be held. Textbook: How to Lie with Statistics by Darrell Huff. A course pack is also required.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 1

MCDB 400(BIOLOGY 400). Advanced Research.

Instructor(s):

Prerequisites & Distribution: 12 credits of biology, 3.0 average in science, and permission of faculty member in biology. (1-3). (Excl). (BS). (INDEPENDENT). May be repeated for credit for a maximum of 9 credits. Continuing Course. Y grade can be reported at end of the first-term to indicate work in progress. At the end of the second term of MCDB 400, the final grade is posted for both term's elections.

Credits: (1-3).

Course Homepage: No homepage submitted.

Intended for those engaged in original laboratory research at an advanced level. This course number is most frequently elected by senior Honors students who have completed MCDB 300 and who are completing their research and writing their thesis. A final paper is required. (Refer to the description of MCDB 300 for more information.)

The work in this course may continue for two semesters. A 'Y' grade can be reported at the end of the first-term to indicate work in progress. At the end of the second term of MCDB 400, the final grade is posted for both term's elections. Students interested in MCDB 400 should obtain the brochure MCDB Department Policies on Undergraduate Research from the Undergraduate Biology Program Office (1111 Natural Science Bldg).

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of instructor required.

MCDB 401(BIOLOGY 401). Advanced Topics in Biology.

Section 001 — Animal Development and Evolution.

Instructor(s): Robert J Denver (rdenver@umich.edu)

Prerequisites & Distribution: Intended for senior concentrators. The prerequisites will be set by the instructor as appropriate for each section. (3). (Excl). (BS). May be repeated for credit for a maximum of 6 credits.

Credits: (3).

Course Homepage: No homepage submitted.

Designed for advanced undergraduate and graduate students, this course will explore the connections between developmental biology, molecular genetics, and animal evolution. Textbook readings will be supplemented with journal club presentations and seminars to further students' understanding of the cellular and molecular basis of the origin and diversification of animal form.

Biology 305, Genetics, is a prerequisite for this section. Students must attend 3-4 seminars held Wednesdays 12-1; dates to be announced.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

MCDB 411(BIOLOGY 411). Protein Structure and Function.

Section 001.

Instructor(s): James Bardwell (jbardwel@umich.edu)

Prerequisites & Distribution: BIOLOGY 310, 311, or BIOLCHEM 415. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: http://biology.lsa.umich.edu/courses/bio411/

Aim: We will introduce students to the state of the art in bioinformatics as it applies to protein sequence analysis and database searching on the web. We will identify three dimensional structural motifs that are commonly found in proteins and discuss how they are related to the protein's functions. We will also consider how proteins fold into their proper 3D structure.

Content: The course will be 2/3 lecture and 1/3 hands on computer manipulation of sequences, modeling, and discussion. The course will also provide guidance in reading and interpreting original scientific literature.

Course material: http://biology.lsa.umich.edu/courses/bio411/ NO required TEXT or course pack, everything is web based

A big part of the course is using the web to analyze sequence of the protein you are interested in. If you have a protein in which you are interested, you can analyze it for credit, otherwise you will be assigned a protein. Techniques you learn will be useful in many areas of work, since biology has gone molecular and structural. The course assumes a very basic level of computer competence but if you have ever surfed the WEB you will do fine.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

MCDB 412(BIOLOGY 412). Teaching Biochemistry by the Keller Plan.

Section 001.

Instructor(s): Kenneth J Balazovich (kbalazo@umich.edu)

Prerequisites & Distribution: BIOLOGY 311 and permission of instructor. (3). (Excl). (EXPERIENTIAL). May not be repeated for credit. May not be included in any of the Biological Sciences concentration programs.

Credits: (3).

Course Homepage: No homepage submitted.

Undergraduates who previously have taken an introductory biochemistry course act as TAs for Introductory Biochemistry (BIOLOGY 311). TAs meet with the instructor for a two-hour class each week for lectures, presentations, and discussions of teaching and biochemistry. TAs also prepare an oral report on a recent advance in biochemistry which they present to their peers and the instructor. The major roles of the TAs are to examine the students on their mastery of unit material and to help the students with explanations supplementary to the textbook. At the completion of an instructor-generated written quiz, the student and TA grade the quiz together. TAs learn considerable biochemistry by repeated teachings of unit materials and, in addition, profit from their experience as teachers and evaluators.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of Instructor

MCDB 418(BIOLOGY 418). Endocrinology.

Section 001.

Instructor(s): Robert J Denver (rdenver@umich.edu)

Prerequisites & Distribution: BIOLOGY 162, 225, and organic chemistry. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: http://www.biology.lsa.umich.edu/courses/bio418/bio418.htm

This course is a comparative study of animal endocrine functions with emphasis on the cellular origin and chemical nature of hormones, the cellular and molecular mechanisms of hormone action, general endocrine control mechanisms, the evolution of hormones and hormonal control and their physiological actions in animals. The course will concentrate on the endocrine systems of vertebrates; there will be limited treatment of human endocrinology. Instruction in MCDB 418 assumes a basic familiarity with general and comparative physiology (BIOLOGY 225 or its equivalent is a prerequisite). Training in chemistry through organic is essential, and courses in biochemistry and cell and molecular biology are helpful.

Textbook: Vertebrate Endocrinology. 3rd. edition. D.O. Norris.

Check Times, Location, and Availability Cost: 2 Waitlist Code: No Data Given.

MCDB 419(BIOLOGY 419). Endocrinology Laboratory.

Section 001.

Instructor(s): Sushama Denver (spavgi@umich.edu)

Prerequisites & Distribution: Prior or concurrent enrollment in BIOLOGY 225 or 310 or 311, or MCDB 418 or 426. (3). (Excl). (BS). May not be repeated for credit. Satisfies a Biology laboratory requirement. Laboratory fee ($70) required.

Credits: (3).

Lab Fee: Laboratory fee ($70) required.

Course Homepage: No homepage submitted.

This laboratory course provides hands-on experience with methods used in endocrinological investigations. The students will learn techniques ranging from the organismal to the molecular level. The course emphasizes hypothesis testing, modern techniques, and data analysis. Prior or concurrent enrollment in MCDB 418 is required to take this course. The enrollment is limited to 12 students. Students should be aware that this course uses live animals. The laboratory will meet twice a week (a four-hour session and a two-hour session), however, students should anticipate an additional two or three hours laboratory time at various (and occasionally odd) times in the week. Course assignments include a term paper, quizzes, and other short assignments.

Check Times, Location, and Availability Cost: 1 Waitlist Code: 1

MCDB 422(BIOLOGY 422). Cellular and Molecular Neurobiology.

Section 001.

Instructor(s): John Y Kuwada (kuwada@umich.edu), Mohammed Akaaboune

Prerequisites & Distribution: BIOLOGY 162, one year of physics, prior or concurrent enrollment in biochemistry. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

This course deals primarily with the properties of individual nerve cells, and small groups of nerve cells. This provides the basis for understanding information processing by the nervous system, learning and memory, development of neurons, and neurological and psychiatric disorders. Considerable emphasis will be placed on understanding the molecules that endow the nervous system with these properties. Textbook: Principles of Neural Science by Kandel, Schwartz & Jessell. McGraw-Hill.

Check Times, Location, and Availability Cost: 2 Waitlist Code: 1

MCDB 423(BIOLOGY 423). Introduction to Research in Cellular and Molecular Neurobiology.

Section 001.

Instructor(s): Richard I Hume (rhume@umich.edu)

Prerequisites & Distribution: Concurrent enrollment in MCDB 422; or completion of BIOLOGY 222 or MCDB 422, and permission of instructor. (3). (Excl). (BS). May not be repeated for credit. Satisfies a Biology laboratory requirement. Laboratory fee ($70) required.

Credits: (3).

Lab Fee: Laboratory fee ($70) required.

Course Homepage: No homepage submitted.

This lab course provides an introduction to experimental approaches in neurobiology. Emphasis is on molecular, anatomical, and physiological approaches for studying neuronal function. Among the molecular topics to be covered are analysis of cDNA clones, PCR amplification of DNA, and expression of genes in foreign tissues. Among the anatomical topics to be covered are gross and microscopic anatomy of nervous systems, axonal pathway tracing, and immunocytochemical localization of specific neuronal proteins. Among the physiological topics to be covered are intracellular and extracellular recording, as well as the use of computers in the acquisition and analysis of data. This course is intended for students who plan to engage in research in neurobiology. A course pack is required.

Check Times, Location, and Availability Cost: 1 Waitlist Code: 5, Permission of Instructor

MCDB 427(BIOLOGY 427). Molecular Biology.

Section 001.

Instructor(s): Rolf Andre Bodmer (rolf@umich.edu) , Jianming Li (jian@umich.edu)

Prerequisites & Distribution: BIOLOGY 305; and BIOLOGY 310 or 311, or BIOLCHEM 415. (4). (Excl). (BS). May not be repeated for credit.

Credits: (4).

Course Homepage: No homepage submitted.

Comprehensive coverage of the general principles governing the structures, synthesis, and functions of DNA, RNA, and proteins in the context of the cell. Emphasizes understanding methods and interpretation of data. Topics include genome organization, DNA replication and transposition, chromosome segregation, transcription and translation, the processing of macromolecules, signal transfer, and regulation at various levels. Two lectures per week are supplemented by a 1.5 hour discussion section. Textbook: Molecular Biology of the Cell by Alberts, et al. (2002).

Check Times, Location, and Availability Cost: 3 Waitlist Code: 1

MCDB 513(BIOLOGY 513). Microbial Genetics.

Section 001.

Instructor(s): Janine Maddock (maddock@umich.edu)

Prerequisites & Distribution: Genetics; and microbiology or biochemistry. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

A lecture course covering the principal aspects of microbial genetics, emphasizing analysis of original papers.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

MCDB 521(BIOLOGY 521). Bacterial Physiology II: Carbon Metabolism.

Section 001 — Meets OCT. 2 - NOV. 4. (Drop/Add deadline=October 8).

Instructor(s): Robert A Bender (rbender@umich.edu)

Prerequisites & Distribution: BIOLOGY 305, and BIOLOGY 310 or 311 or BIOLCHEM 415. (1). (Excl). (BS). May not be repeated for credit.

Mini/Short course

Credits: (1).

Course Homepage: No homepage submitted.

No Description Provided. Contact the Department.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

MCDB 522(BIOLOGY 522). Bacterial Physiology III: Nitrogen Metabolism.

Section 001 — Meets NOV. 6 - DEC. 9. (Drop/Add deadline=November 12).

Instructor(s): Robert A Bender (rbender@umich.edu)

Prerequisites & Distribution: BIOLOGY 305, and BIOLOGY 310, 311, or BIOLCHEM 415. (1). (Excl). (BS). May not be repeated for credit.

Mini/Short course

Credits: (1).

Course Homepage: No homepage submitted.

No Description Provided. Contact the Department.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

MCDB 525(BIOLOGY 525) / CHEM 525. Chemical Biology I.

Section 100.

Instructor(s): Neil Marsh (nmarsh@umich.edu)

Prerequisites & Distribution: CHEM 451, 452, 461, and 463. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: http://coursetools.ummu.umich.edu/2003/fall/chem/525/100.nsf

See Chemistry 525.100.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.


Graduate Course Listings for MCDB.


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