Courses in BIOLOGICAL CHEMISTRY (DIVISION 517)

Beginning Fall Term, 1992, the Department of Biological Chemistry is offering a series of consecutive, one-credit modules that can each be elected independently. Cumulatively, these modules cover the material in the previously offered Biol. Chem. 580 and 590. Biol. Chem. 570, 571, and 572 each lasts approximately one month (from the start of classes in September), meeting three times a week. The fourth module (Biol. Chem. 578) meets once a week for the entire Fall Term.

415. Introductory Biochemistry. Two terms of organic chemistry equivalent to Chem. 225 and 226. No credit granted to those who have completed or are enrolled in Biol. 411. (3-4). (Excl).

This is a one term course in biochemistry. Biochemistry is essentially the identification of the characteristics of living matter. Specifically the course will cover the biochemistry of the living state, the chemistry of biomolecules, energy transformations and chemical reactions in living cells; function of the immune system and action of hormones; self-regulation and self-replication of living organisms. The course begins with a set of 16 objectives in the form of questions, and at the end these objectives are reexamined. The main text is Biochemistry, 3rd ed. by Stryer. Some topics on molecular biology are also covered by Molecular Biology of the Gene, 3rd ed., by Watson. The course is basically a lecture course with handouts provided for emphasis. Four hourly exams and a final examination will be used to evaluate student performance. It is possible to obtain a fourth credit hour by attending an extra series of lectures and preparing a research paper. Cost:2 WL:4 (Menon)

416. Introductory Biochemistry Laboratory. Quantitative analysis (e.g., Chemistry 340 or 348); prior or concurrent election of Biol. Chem. 415. No credit granted to those who have completed or are enrolled in Biol. 429 or Biol. Chem. 516. (3). (Excl).

The goal of this laboratory-lecture course is to introduce students to modern biochemical techniques involving the separation and isolation of large molecules (proteins, DNA, RNA) and small molecules. An enzyme is isolated and purified and then used to study enzyme kinetics; and through this process students are introduced to spectrophotometric analysis, chromatographic (paper, columns, thin-layer) separations, disc gel electrophoresis. Thermodynamic parameters are calculated from an experiment using alcohol dehydrogenase. Students are also introduced to the use of radioisotopes in metabolic studies and radioimmunoassay. Students are expected to be familiar with simple chemical calculations at a level equivalent to that acquired through an introductory level college chemistry course. Previous laboratory work, especially Chemistry 346 or its equivalent is useful. This course is elected by biochemists and chemists and no distinction is made between undergraduates (about three-fourths) and graduates (about one-fourth) in assigning final grades in the course. The course is not related or equivalent to Biology 429. Cost:2 WL:4 (Andrews, Lyons, and Ross)

570. Protein Structure. An introductory biochemistry course (e.g., Biol. Chem. 415) and two terms of organic chemistry. Physical chemistry is strongly recommended. (1).
A detailed introduction to protein structure, including a review of amino acids and properties of peptide bonds; forces that determine protein stability; hierarchy of protein structure; macromolecular x-ray crystallography; comparison and prediction of structure; determination of protein structure by NMR; protein dynamics as studied by NMR; and protein folding and stability. An elective visualization and special topics laboratory is also available.

571. Nucleotide and Polynucleotide Structure. An introductory biochemistry course (e.g., Biol. Chem. 415), two terms of organic chemistry, and Biol. Chem. 570, or equivalent. Undergraduate courses in physical chemistry and in genetics are strongly recommended. (1).

Topics to be covered include: Nucleotide, DNA and RNA structure, DNA-protein interaction and fine structure.

572. Transcription, RNA Processing, and Translation. An introductory biochemistry course (e.g., Biol. Chem. 415), and two terms of organic chemistry, and Biol. Chem. 571, or equivalent. Undergraduate courses in physical chemistry and in genetics are strongly recommended. (1).

Transcription, RNA processing, and translational control.

578. Biochemical Techniques. An introductory biochemistry course (e.g., Biol. Chem. 415), and two terms of organic chemistry. Physical chemistry is strongly recommended. (1).

In-depth discussions of important techniques in biochemistry research, including primary sequence determination of proteins; protein purification; spectroscopy; computer assisted analysis of structure; computer analysis of DNA and protein sequences; protein chemistry; immunological techniques; identifying a gene in a library; electrophoresis; and, directed mutagenesis.


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