Since Fall Term, 1992, the Department of Biological Chemistry has offered a series of consecutive, one-credit modules that can each be elected independently. Cumulatively, these modules cover the material in Biological Chemistry 580 and 590, which was formerly available for LS&A degree credit. Biological Chemistry 570, 571, 572, and 578 were introduced Fall Term 1992. Biological Chemistry 576 and 577 are being introduced Fall Term, 1993. 570, 571, 572, 576, and 577 each last approximately one month (from the start of classes in September), meeting three times a week. Biological Chemistry 578 meets once a week for the entire Fall Term.

415. Introductory Biochemistry. Two terms of organic chemistry equivalent to Chem. 225 and 226. No credit granted to those who have completed or are enrolled in Biol. 411. (3-4). (Excl).

A one term introductory biochemistry course that covers the biochemistry of the living state, the chemistry of biomolecules, energy transformations and chemical reactions in living cells, function of the immune system and action of hormones, and self-regulation and self-replication of living organisms. The course begins with a set of 16 objectives in the form of questions, and at the end these objectives are reexamined. The main textbook is Biochemistry, 3rd ed. by Stryer. Some topics on molecular biology are also covered by Molecular Biology of the Gene, 3rd ed., by Watson. This is a lecture course with handouts provided for emphasis. Four hourly exams and a final exam are used to evaluate student performance. It is possible to obtain a fourth credit hour by attending an extra series of lectures once a week, and writing a research paper. Cost:3 WL:4 (Menon)

416. Introductory Biochemistry Laboratory. Quantitative analysis (e.g., Chemistry 340 or 348); prior or concurrent election of Biol. Chem. 415. No credit granted to those who have completed or are enrolled in Biol. 429 or Biol. Chem. 516. (3). (Excl).

A basic laboratory course in biochemistry techniques. Experiments include studies of the nature of biologically important macromolecules and their components; enzyme purification and kinetics; metabolic experiments with radioactive isotopes; bacterial DNA; as well as other selected projects. Cost:2 WL:4 (Andrews)

570/Biophysics 570. Protein Structure. Two terms of organic chemistry; Biol. Chem. 415 or equivalent; or permission of instructor. Physical Chemistry is strongly recommended. (1). (Excl).

An introduction to three-dimensional protein structure emphasizing the structural basis of protein functionality. After a review of secondary structure, forces that contribute to protein stability, and structure determination techniques, there is an in-depth examination of the structure of at least six proteins, including ones involved in transport, catalysis, membrane electron transport, and cell signaling. Cost:2 WL:4 (Zuiderweg and Saper)

571/Biophysics 571. Nucleic Acids: Structure and Dynamics. Biol. Chem. 570 or equivalent. Undergraduate courses in physical chemistry and genetics are strongly recommended. (1). (Excl).

Topics covered include: Nucleotide, DNA and RNA structure, DNA-protein, and RNA-protein interactions, and fine structure. Cost:2 WL:4 (Thiele)

572. Control of Gene Expression. Biol. Chem. 571 or equivalent. Physical chemistry and genetics are strongly recommended. (1). (Excl).

Transcription, RNA processing, and translational control. Cost:2 WL:4 (Engelke)

576. Membranes and Protein Targetting. Two terms of organic chemistry; Biol. Chem. 415 or equivalent; or permission of instructor. (1). (Excl).

An introduction to membrane structure and protein sorting and trafficking. The course also includes a section on recognition of cell surfaces. Cost:2 WL:4 (Jourdian)

577. Metabolic Regulation. Two terms of organic chemistry; Biol. Chem. 415 and Biol. Chem. 570, 573, and 575, or equivalent. (1). (Excl).

General aspects of metabolic regulation, with an emphasis on the integration of carbohydrate and lipid metabolism. Cost:2 WL:4 (Medzihradsky)

578. Biochemical Techniques. Two terms of organic chemistry; Biol. Chem. 415 or equivalent; or permission of instructor. Physical chemistry is strongly recommended. (1). (Excl).

In-depth discussions of important techniques in biochemistry research, including primary sequence determination of proteins; protein purification; spectroscopy; computer assisted analysis of structure; computer analysis of DNA and protein sequences; protein chemistry; immunological techniques; identifying a gene in a library; electrophoresis; and, directed mutagenesis. Cost:2 WL:4 (Ballou)

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