Courses in Biological Chemistry (Division 517)

415. Introductory Biochemistry. Two terms of organic chemistry. No credit granted to those who have completed or are enrolled in Biol. 310 or 311, or Chem. 451/452. (3-4). (Excl). (BS).

A one term introductory biochemistry course that covers the biochemistry of the living state, the chemistry of biomolecules, energy transformations and chemical reactions in living cells, function of the immune system and action of hormones, and self-regulation and self-replication of living organisms. The course begins with a set of 16 objectives in the form of questions, and at the end these objectives are reexamined. The main textbook is Biochemistry, 3rd ed., by Stryer. Some topics on molecular biology are also covered by Molecular Biology of the Gene, 3rd ed., by Watson. This is a lecture course with handouts provided for emphasis. Four hourly exams and a final exam are used to evaluate student performance. It is possible to obtain a fourth credit hour by attending an extra series of lectures once a week, and writing a research paper. Cost:3 WL:4

416. Introductory Biochemistry Laboratory. Quantitative Analysis; Prior or concurrent election of Biol. Chem. 415 or Chem. 451/452. No credit granted to those who have completed or are enrolled in Biol. 429 or Biol. Chem. 516. (3). (Excl). (BS). Laboratory fee ($50) required.

A basic course in how to conduct and interpret biochemical laboratory experiments. The keeping of notebooks and the writing of literature-style reports are emphasized. The development of controls, design of assays, and evaluation of results and sources of errors are constant themes in this course. Experiments include: spectrophotometry, enzymatic (including coupled) and protein assays, enzyme purification and kinetics, thermodynamic measurements, DNA manipulations, including mapping and cloning, PCR, and forensic testing. It is hoped that students will begin to appreciate the fun and elegance of designing experiments to answer questions and in the process learn some experimental techniques. Cost:2 WL:4

Courses 570-577 and 579 each last one month

572. Control of Gene Expression. Biol. Chem. 571 or equivalent. Physical chemistry and genetics are strongly recommended. (1). (Excl). (BS).

Topic covered include: Transcription, RNA processing, and translational control. Cost:2 WL:4

575. Membranes and Protein Targeting. Two terms of organic chemistry; Biol. Chem. 415 or Chem. 451/452. (1). (Excl). (BS).

An introduction to membrane structure and protein sorting and trafficking. The course also includes a section on recognition of cell surfaces. Cost:2 WL:4

576. Signal Transduction. Two terms of organic chemistry; Biol. Chem. 415 or Chem. 451/452, and Biol. Chem. 570. Physical Chemistry is strongly recommended. (1). (Excl). (BS).

A review of hormone and neurotransmitter receptors as well as the cellular effectors that are regulated by receptor activation. Oncogene products as signal transducers and the interaction of the known signaling pathways are also covered. The course takes a distinctly biochemical approach to the study of these topics. The various techniques used to study signal transduction as well as important experimental strategies employing these techniques are also presented.

577. Metabolic Regulation. Two terms of organic chemistry; Biol. Chem. 415 or Chem. 451/452; and Biol. Chem. 570, 573, and 576, or equivalent. (1). (Excl). (BS).

General aspects of metabolic regulation, with an emphasis on the integration of carbohydrate and lipid metabolism, as well as hormonal control of normal and abnormal metabolism. Cost:2 WL:4

578. Biochemical Techniques. Two terms of organic chemistry; Biol. Chem. 415 or Chem. 451/452. Physical chemistry is strongly recommended. (1). (Excl). (BS).

In-depth discussions of important techniques in biochemistry research, including primary sequence determination of proteins; protein purification; spectroscopy; computer assisted analysis of structure; computer analysis of DNA and protein sequences; protein chemistry; immunological techniques; identifying a gene in a library; electrophoresis; and directed mutagenesis. Cost:2 WL:4

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