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Courses in the Department of Biological Chemistry are listed in the Time Schedule as part of the Medical School's offerings in the subsection Biological Chemistry. The following count as LS&A courses for LS&A degree credit.
415. Introductory Biochemistry.
Two terms of organic chemistry. No credit granted
to those who have completed or are enrolled in Biol. 310 or 311, or Chem. 451/452. (3-4). (Excl). (BS).
A one-term introductory biochemistry course that covers the biochemistry
of the living state; the chemistry of amino acids, proteins, nucleic
acids, carbohydrates, lipids, and steroids; energy transformations
and chemical reactions in living cells; function of immune system
and action of hormones; and self-regulation and self-replication
of living organisms.
Students may elect a fourth credit hour by participating in
a weekly seminar, presented jointly by clinicians and basic scientists, which correlates 415 lecture material with human disease through the use of clinical case studies.
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Times, Location, and Availability
416. Introductory Biochemistry
Laboratory. Quantitative Analysis; Prior or concurrent
election of Biol. Chem. 415 or Chem. 451/452. No credit granted
to those who have completed or are enrolled in Biol. 429 or Biol.
Chem. 516. (3). (Excl). (BS). Laboratory fee ($50) required.
A basic course in how to conduct and interpret biochemical laboratory
experiments. The keeping of notebooks and the writing of literature-style
reports are emphasized. The development of controls, design of
assays, and evaluation of results and sources of errors are constant themes in this course. Experiments include: spectrophotometry, enzymatic (including coupled) and protein assays, enzyme purification
and kinetics, thermodynamic measurements, DNA manipulations, including
mapping and cloning, PCR, and forensic testing. It is hoped that
students will begin to appreciate the fun and elegance of designing
experiments to answer questions and in the process learn some
experimental techniques. Cost:2
WL:4
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Times, Location, and Availability
499. Biochemical Research
for Undergraduates: Laboratory. Biol. Chem. 415 or
Chem. 451/452; permission of the course director. (1-6). (Excl).
(INDEPENDENT). May be repeated for credit.
This course provides an opportunity for students to develop a
special research project under the direct supervision of a faculty
member.
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Times, Location, and Availability
Courses 570-577 each last one month
572. Control of Gene
Expression. Biol. Chem. 571. Physical chemistry and genetics are strongly recommended. (1). (Excl). (BS).
This course addresses transcription mechanism and controls, especially
in eukaryotes. Cost:2
WL:4
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Times, Location, and Availability
575(576). Protein Trafficking.
Two terms of organic chemistry; Biol. Chem. 415 or
Chem. 451/452. (1). (Excl). (BS).
An introduction to membrane structure and protein sorting and trafficking. The course also includes a section on recognition
of cell surfaces. Cost:2
WL:4
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Times, Location, and Availability
576(575). Signal Transduction.
Two terms of organic chemistry; Biol. Chem. 415 or
Chem. 451/452, and Biol. Chem. 570. Physical Chemistry is strongly
recommended. (1). (Excl). (BS).
A review of hormone and neurotransmitter receptors as well as the cellular effectors that are regulated by receptor activation.
Oncogene products as signal transducers and the interaction of the known signaling pathways are also covered. The course takes
a distinctly biochemical approach to the study of these topics.
The various techniques used to study signal transduction as well
as important experimental strategies employing these techniques
are also presented.
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Times, Location, and Availability
577. Metabolic Regulation.
Two terms of organic chemistry; Biol. Chem. 415 or
Chem. 451/452; and Biol. Chem. 570, 573, and 576. (1). (Excl).
(BS).
General aspects of metabolic regulation, with an emphasis on the
integration of carbohydrate and lipid metabolism, as well as hormonal
control of normal and abnormal metabolism. Cost:2
WL:4
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Times, Location, and Availability
578. Biochemical Techniques.
Two terms of organic chemistry; Biol. Chem. 415 or
Chem. 451/452. Physical chemistry is strongly recommended. (1).
(Excl). (BS).
In-depth discussions of important techniques in biochemistry research, including primary sequence determination of proteins; protein
purification; spectroscopy; computer assisted analysis of structure;
computer analysis of DNA and protein sequences; protein chemistry;
immunological techniques; identifying a gene in a library; electrophoresis;
and directed mutagenesis. Cost:2
WL:4
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Times, Location, and Availability
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