College of LS&A

Winter Academic Term 2003 Graduate Course Guide

Note: You must establish a session for Winter Academic Term 2003 on wolverineaccess.umich.edu in order to use the link "Check Times, Location, and Availability". Once your session is established, the links will function.

Courses in Biophysics


This page was created at 8:07 PM on Wed, Feb 5, 2003.

Winter Academic Term, 2003 (January 6 - April 25)

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BIOPHYS 520 / CHEM 520. Biophysical Chemistry I.

Section 001.

Instructor(s): Erik R P Zuiderweg (zuiderwe@umich.edu)

Prerequisites: CHEM 463, BIOLCHEM 415, or CHEM 420; permission of course director. (3). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

This course is the first of a two-term Biophysical Chemistry series BIOPHYS 520/521, but it can be taken as stand-alone course as well. BIOPHYS 520 will introduce and explain the physicochemical properties of biological macromolcules and their complexes, mostly in solution. The course offeres an overview of protein and nucleic acid structures. Intra- and inter-molecular forces, helix-coil transitions, and protein folding will be treated in a thermodynamical context.

Thermodynamics of solutions, configurational statistics, ligand interactions, multi-site interactions, and cooperativity are treated in depth. Kinetics and thermodynamics of protein-ligand binding are discussed. The role of dynamics in protein function is introduced.

Currently, biophysical, biochemical, and pharmacochemical research literature is full with papers interpreting the properties of biological macromolecules on the the basis of their three-dimensional structure. This course will expand on that concept by offering a rigorous background in energetics, folding, interactions, and dynamics. As such the course is important to any student who has to deal with the concepts of biomolecular function and structure such as biochemists, molecular biophysicists, mathematical biologists, and molecular pharmacologists. This course will also serve as a basis for the graduate student who will be specializing in any of these topics for thesis research.

Instructional material: Van Holde, Physical Biochemistry, 1998 and course packs.

Evaluation: homework (40%), midterm exam (30%) and final exam (30%).

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

BIOPHYS 521 / CHEM 521. Biophysical Chemistry II.

Section 001.

Instructor(s): Robert Zand

Prerequisites: CHEM 461, BIOLCHEM 415, and CHEM 430; and permission of course director. (3). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

This course is team-taught and is the second of a two-term biophysical chemistry series, BIOPHYS 520/521, but it can be taken as a stand-alone course. Biophysics 521 provides an overview of the theory and application of spectroscopical techniques of UV/Vis, IR, Flourescence, Single Molecule Detection, CD, and NMR. Other topics covered include X-ray crystallography, computational methods, light scattering, ultracentrifugation. When possible, hands-on opportunities in applying some of these techniques will be offered.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

BIOPHYS 642 / MICRBIOL 642. Molecular and Cellular Immunology III.

Section 001.

Instructor(s): Malini Raghavan (malinir@umich.edu)

Prerequisites: BIOLOGY 305 and BIOLCHEM 415 and MCDB 436/MICRBIOL 502; Graduate standing. (1). May not be repeated for credit.

Mini/Short course

Credits: (1).

Course Homepage: No homepage submitted.

This one-credit course will consist of lectures and discussions pertaining to receptor-ligand interactions in the immune system. The goal of the course is to provide students a broad overview of the structural basis of immune function by reviewing recent literature. Recommended Reading: Literature-based. Prerequisites: BIOLOGY 305 and BIOLCHEM 415; permission of instructor for undergraduates or NCFD. This course is an appropriate sequel to MICROBIOL 502/ MCDB 436 and BIOLCHEM 570. Lectures.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

BIOPHYS 801. Seminar by Molecular Biophysics Trainees.

Section 001.

Instructor(s): Martha L Ludwig (mludwig@umich.edu)

Prerequisites: Graduate standing. (1). May not be repeated for credit.

Credits: (1).

Course Homepage: No homepage submitted.

Students in Molecular Biophysics fulfill the requirements for a Ph.D. in either Biological Chemistry, Biophysics, Chemistry, or Physics. Training in Molecular Biophysics aims to develop independent investigators who will contribute in significant ways to advances in understanding structural and cellular biology at the molecular level. Students concentrating in Molecular Biophysics elect courses in areas such as protein structure and function, techniques in NMR and crystallography, and spectroscopic methods.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

BIOPHYS 890. Introduction to Research.

Instructor(s):

Prerequisites: Research rotations: Primarily for students in the Biophysics Graduate Program. Graduate Standing. Permission of instructor required. (1-4). (INDEPENDENT). May not be repeated for credit.

Credits: (1-4).

Course Homepage: No homepage submitted.

The main focus is to offer research training in the applications of physics-based techniques to biological systems ranging in complexity from single molecules to whole cells and tissues.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of Department

BIOPHYS 995. Dissertation/Candidate.

Instructor(s):

Prerequisites: Graduate School authorization for admission as a doctoral Candidate. Graduate Standing. (8). (INDEPENDENT). May be repeated for credit.

Credits: (8; 4 in the half-term).

Course Homepage: No homepage submitted.

Graduate School authorization for admission as a doctoral Candidate. N.B. The defense of the dissertation (the final oral examination) must be held under a full term Candidacy enrollment period.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of Department


Undergraduate Course Listings for BIOPHYS.


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