College of LS&A

Winter Academic Term 2004 Graduate Course Guide

Note: You must establish a session for Winter Academic Term 2004 on wolverineaccess.umich.edu in order to use the link "Check Times, Location, and Availability". Once your session is established, the links will function.

Courses in Biophysics


This page was created at 6:17 PM on Wed, Jan 21, 2004.

Winter Academic Term 2004 (January 6 - April 30)


BIOPHYS 503 / CHEM 603. Biomolecular NMR: Structure & Dynamics in Solution & Solids.

Section 001.

Instructor(s): Erik R P Zuiderweg (zuiderwe@umich.edu)

Prerequisites: Graduate standing. (3). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

After a classical introduction into 2D NMR, principles of multidimensional NMR will be treated, including quantum mechanical methods such as Density Matrices, Product Operators, Propagators and perturbation theory. Biomolecular applications of two-dimensional proton NMR and three- and four-dimensional heteronuclear NMR will be extensively covered. Methods applicable for solution as well as for solid samples will be introduced. Applications center on protein structure determination but nucleic acids NMR and relaxation experiments for the detection of molecular dynamics will be treated as well. An introduction into solid-state NMR will focus around the methods such as cross polarization, MAS, line-narrowing multiple-pulse techniques. Applications will be covered in the last lecture.

We will be using a course pack which is mostly based on materials of the following books:
Wuthrich, NMR of Proteins and Nucleic Acids (Wiley)
Slichter, Principles of Magnetic Resonance, (Harper and Row)
Van de Ven, Multidimensional NMR in Liquids, (VCH)
Cavanagh et al. : Protein NMR Spectroscopy, (Academic Press)
Evans, Biomolecular NMR spectroscopy, (Oxford)

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

BIOPHYS 521 / CHEM 521. Biophysical Chemistry II.

Section 001.

Instructor(s): Robert Zand

Prerequisites: CHEM 461, BIOLCHEM 415, and CHEM 430; and permission of course director. (3). May not be repeated for credit.

Credits: (3).

Course Homepage: http://coursetools.ummu.umich.edu/2004/winter/biophys/521/001.nsf

This course is team-taught and is the second of a two-term biophysical chemistry series, BIOPHYS 520/521, but it can be taken as a stand-alone course. Biophysics 521 provides an overview of the theory and application of spectroscopical techniques of UV/Vis, IR, Flourescence, Single Molecule Detection, CD, and NMR. Other topics covered include X-ray crystallography, computational methods, light scattering, ultracentrifugation. When possible, hands-on opportunities in applying some of these techniques will be offered.

Textbooks: "Biophysical Chemistry", part 1, Canton, 0716711885, publ Freeman "Biophysical Chemistry", part 2, Canton, 0716711923, publ Freeman "Proteins", Creighton, 0716732688, publ Freeman

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of instructor

BIOPHYS 602 / CHEM 602 / CMBIOL 602. Protein Crystallography: Principles of Macromolecular Crystallography.

Section 001.

Instructor(s): Martha L Ludwig

Prerequisites: Physical Chemistry. Graduate standing. (2). May not be repeated for credit.

Credits: (2).

Course Homepage: No homepage submitted.

See CHEM 602.001.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of Instructor

BIOPHYS 642 / MICRBIOL 642. Molecular and Cellular Immunology III.

Section 001 — MEETS MAR 21-APR 20. (Drop/Add deadline=April 2).

Instructor(s): Malini Raghavan (malinir@umich.edu)

Prerequisites: BIOLOGY 305 and BIOLCHEM 415 and MCDB 436/MICRBIOL 502; Graduate standing. (1). May not be repeated for credit.

mini/short

Credits: (1).

Course Homepage: No homepage submitted.

This one-credit course will consist of lectures and discussions pertaining to receptor-ligand interactions in the immune system. The goal of the course is to provide students a broad overview of the structural basis of immune function by reviewing recent literature. Recommended Reading: Literature-based. Prerequisites: BIOLOGY 305 and BIOLCHEM 415; permission of instructor for undergraduates or NCFD. This course is an appropriate sequel to MICROBIOL 502/ MCDB 436 and BIOLCHEM 570. Lectures.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

BIOPHYS 801. Seminar by Molecular Biophysics Trainees.

Section 001.

Instructor(s): James Penner-Hahn (jeph@umich.edu)

Prerequisites: Graduate standing. (1). May not be repeated for credit.

Credits: (1).

Course Homepage: No homepage submitted.

Students in Molecular Biophysics fulfill the requirements for a Ph.D. in either Biological Chemistry, Biophysics, Chemistry, or Physics. Training in Molecular Biophysics aims to develop independent investigators who will contribute in significant ways to advances in understanding structural and cellular biology at the molecular level. Students concentrating in Molecular Biophysics elect courses in areas such as protein structure and function, techniques in NMR and crystallography, and spectroscopic methods.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

BIOPHYS 890. Introduction to Research.

Instructor(s):

Prerequisites: Research rotations: Primarily for students in the Biophysics Graduate Program. Graduate Standing. Permission of instructor required. (1-4). (INDEPENDENT). May not be repeated for credit.

Credits: (1-4).

Course Homepage: No homepage submitted.

The main focus is to offer research training in the applications of physics-based techniques to biological systems ranging in complexity from single molecules to whole cells and tissues.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of instructor/department

BIOPHYS 990. Dissertation/Precandidate.

Instructor(s):

Prerequisites: Election for dissertation work by doctoral student not yet admitted as a Candidate. Graduate Standing. (1-8). (INDEPENDENT). May be repeated for credit. This course has a grading basis of "S" or "U."

Credits: (1-8; 1-4 in the half-term).

Course Homepage: No homepage submitted.

Election for dissertation work by doctoral student not yet admitted as a Candidate.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of Department

BIOPHYS 995. Dissertation/Candidate.

Instructor(s):

Prerequisites: Graduate School authorization for admission as a doctoral Candidate (Prerequisites enforced at registration). (8). (INDEPENDENT). May be repeated for credit. This course has a grading basis of "S" or "U."

Credits: (8; 4 in the half-term).

Course Homepage: No homepage submitted.

Graduate School authorization for admission as a doctoral Candidate. N.B. The defense of the dissertation (the final oral examination) must be held under a full term Candidacy enrollment period.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of Department


Undergraduate Course Listings for BIOPHYS.


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This page was created at 6:17 PM on Wed, Jan 21, 2004.


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