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LSA Course Guide Search Results: UG, GR, Winter 2007, Dept = MCDB
 
Page 1 of 1, Results 1 — 23 of 23
Title
Section
Instructor
Term
Credits
Requirements
MCDB 300 — Undergraduate Research
Section 001, IND

WN 2007
Credits: 1 — 3
Reqs: BS
Other: INDEPENDENT

MCDB 300 is intended primarily for juniors, including Biology or CMB Honors students, who wish to pursue independent research at an intermediate level in an area of biological science. Students may ask an appropriate faculty member in the Department of Molecular Cellular and Developmental Biology to direct the research project and supervise related readings. Alternatively, students may identify a research advisor in another LS&A department, the UM Medical School, or another unit on the UM campus. Students conducting independent research in such outside units must identify a co-sponsor within the Department of MCDB. Independent research is defined as a laboratory project in which the student will have a say in the design, conduct, and interpretation of experiments. Library research projects and lab projects which are strictly a technical training experience do not qualify for credit as undergraduate research. A final paper is required and must be approved by the research advisor.

Advisory Prerequisite: Eight credits of BIOLOGY/MCDB courses; 3.0 GPA in science courses; and permission of instructor.

MCDB 302 — Teaching Experience for Undergraduates
Section 001, IND

WN 2007
Credits: 1 — 3
Other: Expr

Undergraduates participating in this course are responsible for (1) aiding regularly assigned Teaching Assistants; (2) providing tutorial help for undergraduates enrolled in the course; (3) meeting regularly with discussion and laboratory sessions; and (4) participating with Teaching Assistants in instructional activities.

Advisory Prerequisite: Permission of instructor.

MCDB 306 — Introductory Genetics Laboratory
Section 001, LEC

Instructor: Jeyabalan,Santhadevi; homepage

WN 2007
Credits: 3
Reqs: BS

This course provides students with laboratory experience in basic genetic principles. Students will analyze patterns of inheritance, gene interaction, linkage relationship, and genetic mapping of unknown mutants of Drosophila through a series of genetic crosses. By using molecular techniques such as polymerase chain reaction (PCR) and gel electrophoresis, mutations in Caenorhabditis elegans will be mapped to chromosomal locations. The experiments in microbial genetics include mapping by conjugation in E. coli; recombination analysis by transduction using bacteria and phage; and complementation tests on 'his' mutants of yeast. Experiments in human population genetics include calculating allelic frequencies of PTC tasting in the class. Students also will be doing DNA fingerprinting of a VNTR locus using their own squamous epithelial cells. A computer exercise on bioinformatics is included.

One one-hour lecture on Mondays 1-2 p.m. and one three-hour lab are scheduled each week; an additional three to four hours of lab time per week are expected at irregular times. Students are expected to write one formal lab report, three short lab reports, and to keep a complete and accurate record of all results and analyses in a bound lab notebook. There are two tests given during the term.

Students will need to purchase a lab manual, which is available at one of the copy centers: MCDB 306 Genetics Laboratory Manual. S. Jeyabalan (available in the Michigan Union Bookstore).

Advisory Prerequisite: Prior or concurrent enrollment in BIOLOGY 305

MCDB 308 — Developmental Biology Laboratory
Section 001, LEC

Instructor: Jeyabalan,Santhadevi; homepage

WN 2007
Credits: 3
Reqs: BS

This course provides students with the opportunity to study first-hand the development of a number of live vertebrate and invertebrate embryos, specifically sea urchin, amphibian, and chick embryos. In addition to observation of normal embryogenesis, students perform several of the experimental analyses that have contributed to a basic understanding of developmental processes.

Exercises focus on fertilization, developmental morphology, induction, determination and differentiation of various tisses, metamorphosis, and regeneration. Students perform "in vitro" culturing of embryonic tissues, chemical and surgical manipulation of embryos. In additon to one hour of lecture and one scheduled three-hour laboratory session each week, students are expected to spend about three additional hours in the laboratory each week.

Grades are based on two laboratory tests, a term paper with poster presentation, and lab notebook evaluation. Maintenance of a lab notebook for a complete and accurate record of observations and experimental results is required. There is a required lab manual.

Textbook: Patterns and Experients in Developmental Biology, by Leland G. Johnson.

Advisory Prerequisite: Prior or concurrent enrollment in BIOLOGY 208 or MCDB 307 or permission of instructor

MCDB 400 — Advanced Research
Section 001, IND

WN 2007
Credits: 1 — 3
Reqs: BS
Other: INDEPENDENT

Intended for those engaged in original laboratory research at an advanced level. This course number is most frequently elected by senior Honors students who have completed MCDB 300 and who are completing their research and writing their thesis. A final paper is required. (Refer to the description of MCDB 300 for more information.) The work in this course may continue for two semesters. A 'Y' grade can be reported at the end of the first-term to indicate work in progress. At the end of the second term of MCDB 400, the final grade is posted for both term's elections. Students interested in MCDB 400 should obtain the brochure MCDB Department Policies on Undergraduate Research from the Undergraduate Biology Program Office (1111 Natural Science Bldg).

Enforced Prerequisites: MCDB 300

Advisory Prerequisite: 12 credits of biology, 3.0 average in science, and permission of faculty member in biology

MCDB 403 — Molecular and Cell Biology of the Synapse
Section 001, LEC

Instructor: Akaaboune,Mohammed; homepage

WN 2007
Credits: 3
Reqs: BS

This course is intended for advanced undergraduate and graduate students interested in learning the detailed mechanisms of synapse function and development. Topics include mechanisms of neurotransmitter release; synapse development (formation, elimination, maturation); and synaptic plasticity. This course is roughly divided into formal lectures and research papers related to the lectures.

Enforced Prerequisites: Bio 310, Bio 311, BioChem 415, or Chem 451/452

Advisory Prerequisite: BIOLOGY 305 and MCDB 422

MCDB 413 — Plant Molecular Biology Laboratory
Section 001, LAB

Instructor: Pichersky,Eran
Instructor: Schmidt,Adam J

WN 2007
Credits: 3
Reqs: BS

This is a project lab in which students learn to identify and analyze plant genes and gene products using the latest techniques of molecular biology. Emphasis will be on genes encoding unique plant characteristics. Students will first isolate genes from DNA libraries of various plant species. They will then analyze the sequence of genes they have isolated by DNA sequencing, and will characterize their expression levels by various techniques. The genes will then be manipulated to produce the gene products (i.e., proteins) in a bacterial system.

Enforced Prerequisites: BIOLOGY 305; and BIOLOGY 310, 311, BIOLCHEM 415. or CHEM 451; or Graduate standing.

MCDB 415 — Microbial Genetics
Section 001, LEC

Instructor: Chapman,Matthew R

WN 2007
Credits: 3
Reqs: BS

This is a lecture course covering the principal aspects of microbial genetics, with emphasis on analyzing original papers. We will review the current state of recombinant DNA research and discuss the application of these techniques to solving problems in basic and applied research fields.

Textbook: Larry Snyder and Wendy Champness, Molecular Genetics of Bacteria, 2nd edition.

Enforced Prerequisites: BIOLOGY 305; and one of BIOLOGY 310, 311, BIOLCHEM 415, 451/452, or CHEM 451/452

MCDB 423 — Introduction to Research in Cellular and Molecular Neurobiology
Section 001, LAB

Instructor: Ameziane,Rafiqa; homepage
Instructor: Punthambaker,Sukanya Srinivasa Rao Arun

WN 2007
Credits: 3
Reqs: BS

This course provides an introduction to state-of-the-art research approaches in cellular and molecular neurobiology. The course is divided into three modules: electrophysiological methods, anatomical methods, and molecular biological methods.

Enforced Prerequisites: BIOLOGY 222 or MCDB 422

MCDB 423 — Introduction to Research in Cellular and Molecular Neurobiology
Section 002, LAB

Instructor: Ameziane,Rafiqa; homepage
Instructor: Horstick,Eric James

WN 2007
Credits: 3
Reqs: BS

This course provides an introduction to state-of-the-art research approaches in cellular and molecular neurobiology. The course is divided into three modules: electrophysiological methods, anatomical methods, and molecular biological methods.

Enforced Prerequisites: BIOLOGY 222 or MCDB 422

MCDB 426 — Molecular Endocrinology
Section 001, LEC

Instructor: Duan,Cunming; homepage

WN 2007
Credits: 3
Reqs: BS

This course is designed to provide students with a comprehensive overview on the latest advances in our understanding of how hormones work at the molecular and cellular level in vertebrate systems, including humans. This course is intended for advanced undergraduate students, premedical students, and beginning graduate students.

The course will begin with an overview of the vertebrate endocrine systems. We will then examine several topics, including growth factor biology, hormone receptors, intracellular signal transduction mechanisms, and hormonally regulated gene expression. A portion of this course will be devoted to discussing specific topics (i.e., hormones and cancer, environmental endocrine disrupters, etc.) and reading relevant research publications.

The class seeks to develop skills in integration, problem solving, and writing. For example, we are living in an age where information abounds. However, information is not knowledge, and knowledge is not practice. To make information useful, and to provide a foundation for its application in practice, organizing principles are necessary. Approaching endocrinolgy in terms of principles facilitates prediction and understanding of differences in function that occur among organisms. Thus, the core of the course is general principles.

Practice comes from applying knowledge in various situations. Questions will be presented and discussed as part of lectures, and exams will typically include application of principles to novel situations, etc. Exams typically require short answers in which logical presentation and other writing skills are important.

Students will have completed a Biochemistry course and a Physiology course. A course in Endocrinolgoy is helpful but not required. MCDB 426 will review some background material on Endocrinology.

Course Text: Textbook of Endocrine Physiology, 5th edition, J.E. Griffin and S.R Ojeda, eds., Oxford University process, 2004. ISBN10: 0-19-516566-7 and ISBN13: 978-0-19-516566-1

Advisory Prerequisite: BIOLOGY 225; and BIOLOGY 310, 311, or BIOLCHEM 415

MCDB 428 — Cell Biology
Section 001, LEC

Instructor: Wang,Yanzhuang
Instructor: Chang,Amy

WN 2007
Credits: 4
Reqs: BS

Credit Exclusions: Students with credit for MCDB 320 must obtain permission of instructor.

MCDB 428 is designed to provide students with a comprehensive overview of the biology of eukaryotes and prokaryotes at the cellular and molecular level. This course is intended for upper-level undergraduates and graduate students. The information is presented at a level that requires students to integrate information from their other biology, chemistry, and biochemistry courses.

The following topics will be included: general techniques used in cell biology; general properties of membranes; secretion, endocytosis, and related processes; organelle biogenesis; signal transduction; lipoprotein metabolism; cytoskeleton and cell motility; cell cycle and its regulation; cell-cell and cell-matrix interactions; programmed cell death; functions of specialized cell types.

Students will be expected to integrate the scientific data presented in class as well as to read and interpret basic research drawn from the current scientific literature. Grades will be based on three exams and the discussion section.

Textbook: Molecular Biology of the Cell, R. Alberts, et al., Garland Science, 2002.

Enforced Prerequisites: BIOLOGY 310, 311, BIOLCHEM 415, or CHEM 451; or Graduate standing.

MCDB 429 — Laboratory in Cell and Molecular Biology
Section 001, LEC

Instructor: Balazovich,Kenneth J; homepage

WN 2007
Credits: 3
Reqs: BS

Credit Exclusions: No credit granted to those who have completed or are enrolled in BIOLCHEM 416 or 516.

This laboratory course encompasses a broad spectrum of common methods and theory essential to Cellular and Molecular Biology concentrations. The 90-minute lecture each week is used to introduce methodology and techniques that will be encountered in the lab. Two weekly lab sessions are arranged in a project-based format. The projects include several kinds of microscopy, cellular organelle isolation, gel electrophoresis, Western blotting, column chromatography, and tissue culture, in addition to molecular biology methods such as plasmid construction, transfection, polymerase chain reaction, and Southern blotting.

Grades are based on three exams, laboratory quizzes, and a semester-long grant proposal project that may be completed individually or in a self-organized group. This course can be used to satisfy requirements for the Cell and Molecular Biology Concentration and the Biology Concentration.

Textbooks: Laboratory DNA Science, M.V. Bloom, et al.
Preferred: Molecular Cell Biology, H. Lodish, et al.

Advisory Prerequisite: MCDB 427 or 428, or concurrent enrollment in MCDB 428.

MCDB 430 — Molecular Biology of Plants
Section 001, LEC

Instructor: Yocum,Charles F; homepage

WN 2007
Credits: 3
Reqs: BS

The topic of this course is major advances in understanding molecular processes in plants, and the contribution of molecular biological techniques to these advances. The course is intended for advanced undergraduates and beginning graduate students. The course will begin with an overview of the basic techniques of plant molecular biology such as cloning and sequencing of DNA, transformation, and analysis of gene expression. We will then examine selected topics in detail, including proteins, biochemical pathways, photoreception, photosynthesis, and respiration. We will read and then discuss research publications in class. Student performance will be evaluated on the basis of class participation, two take-home examinations, and a term paper.

Textbook: Biochemistry and Molecular Biology of Plants, B. Buchanan, W. Gruissem, R.L. Jones, eds. John Wiley & Sons. (softbound)

Enforced Prerequisites: BIOLOGY 305; and one of: BIOLOGY 310, 311, BIOLCHEM 415, 451, CHEM 451; or Graduate standing

MCDB 469 — Signal Transduction
Section 001, LEC

Instructor: Cadigan,Kenneth M; homepage

WN 2007
Credits: 3
Reqs: BS

This course will cover selected aspects of animal signal transduction, focusing on critical reading and presentation of primary research papers. It will also emphasize the importance of combining genetic and biochemical approaches to gain a better understanding of cellular processes. Topics will include TGF-beta, Wnt, and MAP Kinase signaling.

Grades will be determined by discussion in class, an oral presentation, and two written assignments. The course is intended for junior or senior CMB concentrators (who have taken either MCDB 427 or 428) and graduate students. The class will meet twice weekly for 90 minutes. Contact the instructor at cadigan@umich.edu with any questions regarding the course.

Enforced Prerequisites: MCDB 427 or 428

MCDB 615 — Topics in Cellular and Molecular Biology
Section 001, SEM

Instructor: Clark,Steven E; homepage

WN 2007
Credits: 3

A course in seminar format for reading and discussing reviews and original research papers on genetic approaches to cell biological problems.

Advisory Prerequisite: MCDB 427 and 428; Graduate standing and permission of instructor.

MCDB 700 — Advanced Studies
Section 001, IND

WN 2007
Credits: 1 — 8

An introduction to the research methods in zoology requiring examination of original literature, experimental work on the subject of investigation, and writing of a report.

Advisory Prerequisite: BIOLOGY,Permission of instructor

MCDB 800 — Biology Seminars
Section 001, SEM
TOPICS IN DEVELOPMENTAL NEUROBIOLOGY.

Instructor: Kuwada,John Y

WN 2007
Credits: 1

A graduate seminar course providing opportunity to discuss current work and new developments in Developmental Neurobiology.

Advisory Prerequisite: Graduate standing and permission of instructor.

MCDB 800 — Biology Seminars
Section 002, SEM
PLANT CELL AND MOLECULAR BIOLOGY.

WN 2007
Credits: 1

A graduate seminar course providing opportunity to discuss current work and new developments in Plant Cell and Molecular Biology.

Advisory Prerequisite: Graduate standing and permission of instructor.

MCDB 800 — Biology Seminars
Section 003, SEM
PREPARING FUTURE FACULTY.

Instructor: Olsen,Laura J; homepage

WN 2007
Credits: 1

A graduate seminar course providing opportunity to discuss current work and new developments in Molecular, Cellular, and Developmental Biology.

Advisory Prerequisite: Graduate standing and permission of instructor.

MCDB 801 — Supervised Teaching
Section 001, IND

WN 2007
Credits: 1 — 2

Seminars, demonstrations, and orientation for college teaching in biology. Available for all pre-candidate teaching assistants.

Advisory Prerequisite: Graduate standing and permission of instructor. Appointment as Teaching Assistant in Biology.

MCDB 990 — Dissertation/Precandidate
Section 001, IND

WN 2007
Credits: 1 — 8

Election for dissertation work by doctoral student not yet admitted as a Candidate.

Advisory Prerequisite: Election for dissertation work by doctoral student not yet admitted as a Candidate. Graduate standing.

MCDB 995 — Dissertation/Candidate
Section 001, IND

WN 2007
Credits: 8

Graduate School authorization for admission as a doctoral Candidate. N.B. The defense of the dissertation (the final oral examination) must be held under a full term Candidacy enrollment period.

Enforced Prerequisites: Graduate School authorization for admission as a doctoral Candidate

 
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