Biological Sciences

Courses in Biology (DIVISION 328)

100. Biology for Nonscientists. Not open to concentrators in the biological sciences. (4). (NS).

Biology 100 is a one term course designed to introduce students to current biological concepts. It can be taken to satisfy distribution requirements under Patterns I, II, or III. The course consists of three hours of lecture per week plus a coordinated discussion session which occupies two hours per week. Biology 100 provides an introduction to some general principles of biology and concentrates on the areas of cell biology, genetics, ecology, and evolution. Within these areas topics such as cell structure, cell metabolism, nutrition, human genetics, genetic engineering, nature of evolution, and sociobiology will be discussed. A major objective of this course is to point out to students the nature of the scientific process and illustrate the uses and non-uses of science in contemporary life. Wherever possible the ethical and social implications of contemporary scientific effort will be discussed.

This course is designed for students with a minimal background in the biological sciences but we do assume some exposure to biology at the high school level. Discussion sections enroll 20 students and are taught by graduate student teaching assistants. In the discussion section students have the opportunity to review material presented in lecture, observe and perform experiments which illustrate lecture material, and participate in discussions of issues raised in the lecture segment. Attendance at the discussion section is required. Course grade is determined on the basis of three lecture examinations (300 points) and upon discussion quizzes and papers (100 points). (Brown, Martin, Smith)

112. Introduction to Biology: Term A. Chem. 123 or 107 or the equivalent recommended. No credit is granted to those who have completed 105. (4). (NS).

Biology 112 is the first term of a two-term introductory biology sequence (112/114). The sequence is intended for concentrators in biological and other science programs, premedical or other preprofessional students. Other students wishing detailed coverage of biology and having suitable prerequisites are also welcome. The aims of Biology 112/114 are to provide factual and conceptual knowledge of biology; to afford suitable experience in obtaining and interpreting biological data, including formulation and testing of hypotheses; and to give an integrated overview of present-day biology. The topical coverage of Biology 112 is about equally divided among three areas, in the following sequence: (a) cellular and molecular biology; (b) genetics and developmental biology; (c) microbial and plant biology (structure, function, diversity).

Each week, students are expected to attend three lectures and one three hour laboratory/discussion section. Students must attend their regularly assigned laboratory/discussion meetings starting with the first week of the course or their space may be given to someone else on the waiting list. There will be three course-wide examinations and a final examination, as well as supplementary films and review sessions. Students must be sure to reserve appropriate times and dates for these activities (specified in the Time Schedule). In addition, regular attendance at all laboratories and discussions, and written laboratory reports are required for completion of the course.

The required textbook, laboratory manual, and course pack of syllabus and lecture notes are available at bookstores. Students should not buy any study guides or other supplementary materials for this course.

Students seeking Honors credit in introductory Biology must enroll concurrently in Biology 112 (section 002-H) and RC Natural Science 113 (designated Honors sections only). For further information contact the Honors Office, 1210 Angell Hall.

Note concerning prerequisites. There are no prerequisites for Biology 112, but a one-term chemistry course at the college level is strongly recommended. (Gay, Anderson, Shappirio)

Section 013: Permission of Comprehensive Studies Program (CSP). This CSP section, which covers the complete course syllabus, is designed for students who want to be certain they are highly prepared for Biology 114 and are willing to devote the effort necessary to do so. Extra class time is provided for in-depth analysis of central concepts. Therefore, enrollment in this CSP section will entail laboratories exercises and discussion time beyond the regular course requirements.

114. Introduction to Biology: Term B. Biol. 112. No credit is granted to those who have completed 105. (4). (NS).

The course is a continuation of Biology 112, including the following topics: (a) evolutionary biology; (b) ecology and behavior; and (c) animal biology (structure, function and diversity). Aims and format are stated above for Biology 112. Students must attend their regularly assigned laboratory/discussion section starting with the first week of the course, or their space may be given to someone else on the waiting list. For information concerning the textbook and laboratory manual, contact bookstores. Further information about this course can be obtained from the Biology 112/114 office in Room 1570 C.C. Little Building. (Grant, O'Connor, Tosney)

123. Human Sexuality. Not open to students concentrating in the biological sciences. (3). (NS).

Human Sexuality is designed to introduce students to the biological and social factors which determine and regulate their sexuality. Approximately two-thirds of the course deals with the anatomical, physiological and genetic determinants of sexuality. In this section the sexual anatomy of men and women, hormonal regulation of sexual function, fertilization, pregnancy, birth, lactation, conception control, and venereal diseases are examined. In the latter third of the course emphasis shifts to behavioral and social factors. Here, human sexual behavior, sexual response, orgasm, psychosexual development, homosexuality, rape, and the genesis of sex roles are examined. The evolution of sexuality in both humans and other animals is a recurrent theme in this course. Biology 123 is designed for students with a minimal background in biological science. Even so you will profit more from this course if you have had some exposure to high school biology. Biology 123 is a logical counterpart to Biology 100 and Physiology 101. The text to be used in the course will be Katchadourian and Lunde, Fundamentals of Human Sexuality, 3rd ed., 1980. (J. Allen)

262. Biology of Cancer. One term of introductory biology or permission of instructor. (3). (NS).

The Biology of Cancer is a lecture/discussion course designed to provide students with a basic understanding of the biological events associated with the formation of cancer. This course is organized around three fundamental questions: what is cancer, what are the causes of cancer, and can cancer be cured or prevented? Lectures will include descriptions of classical and recent experiments which address these questions, and will also provide students with the vocabulary and background needed to critically read and evaluate technical literature dealing with the subject of cancer. Although introductory biology is an essential prerequisite for this course, an attempt will be made to accommodate the needs and interests of students of varying backgrounds, including non-biology majors. Student performance will be evaluated by a combination of quizzes, exams, and a term paper based upon library research. In order to provide the time required for this library research, the lecture-discussion meetings will be dismissed for approximately two weeks late in the term. There will be no assigned textbook, but an extensive reserve list of relevant books will be available in the Natural Science Library. The class will meet twice a week for an hour and a half; in general, meetings will consist of a one hour lecture followed by questions and discussion. (Kleinsmith)

291/Micro. 291. Microbiology Laboratory. Micro. 101 or Biol. 105 or 112-114; or permission of instructor. (3). (NS).

The revolutionary advances in molecular biology, and their impact on society are based on the study and utilization of microorganisms. This laboratory experience helps form a sound foundation for all of the biological sciences. The course consists of one orientation lecture and two laboratory sessions each week. Topics covered include an introduction to microbial variety, methods of study, specific techniques, and general consideration of microbes in the world around us. The course is required in the microbiology concentration program, and is appropriate for concentrators in biology, botany, and cell biology. Evaluation is based on performance on three exams, and a variable number of quizzes, practical exams, and written reports. There is no required text. (Helling)

305. Genetics. Biol. 105 or 112 (or the equivalent). (4). (NS).

This course is designed for students who are majoring in the natural sciences, or who intend to apply for graduate or professional study in basic or applied biological sciences. This introduction to genetics is divided into the following segments: DNA and chromosomes, gene transmission in Eukaryotes, linkage and recombination, mutation and its consequences, gene expression and regulation, population genetics. There are three hours of lecture a week and one discussion section directed by teaching assistants. The discussion sections are used to introduce relevant new material, to expand on and review the lecture material, and to discuss problem assignments. Grading is based on examinations covering the lecture material, discussion material, reading assignments in the text, and new problems that test applications of basic concepts and genetic techniques. Practice problem sets designed for this course will be available and are covered in discussion sections or the Genetics Clinic where all office hours of TA's are held. Two demonstrations of living material and genetic tools are given during the term. Required text: Goodenough, Genetics, Third Edition, 1984. (S. Allen)

392. Introductory Developmental Biology. Biol. 105, or Biol. 112 and 114 (or the equivalent). (3). (NS).

This course is designed to introduce students to the basic principles of developmental biology. Special emphasis will be placed upon the continuity of developmental processes in terms of 1) the temporal sequence of development from the fertilized egg to the adult and 2) levels of control, from the expression of genetic information to the organization of complex tissues and organs. Whenever possible, the experimental basis for our understanding of developmental events will be stressed. Major areas of coverage will include gametogenesis, fertilization, early embryogenesis including maternal control and nucleocytoplasmic interactions, induction and morphogenetic movements, cellular interactions in organogenesis, and morphogenesis. Certain aspects of postnatal development, such as regeneration, will also be covered. This course is intended for juniors and seniors, but it is also open to sophomores. There are three one-hour lectures per week. (Carlson, Jeyabalan)

393. Developmental Biology Laboratory. Prior or concurrent enrollment in Biol. 392. (2). (NS).

This course provides students with the opportunity to study firsthand the development of a number of live vertebrate and invertebrate embryos. In addition to observation of normal embryogenesis, students perform several of the experimental analyses which have contributed to a basic understanding of developmental processes. Exercises focus on fertilization, developmental morphology, induction, determination and differentiation of various tissues, metamorphosis and regeneration. In addition to one scheduled three-hour laboratory session each week, students are expected to spend about three additional hours in the laboratory each week. Short lectures are presented to introduce aspects of basic morphological areas of investigation. Formal reports on two exercises are required. There are three laboratory tests. Maintenance of lab note book for a complete and accurate record of observations and experimental results is required. There is a required lab manual. (Jeyabalan)

401/Micro. 401. General Microbiology. Biochemistry (Biol. 411 or Biol. Chem. 415); preceded or accompanied by Biol. 305. (3). (NS).

This course is a comprehensive introduction to microbiology. Lectures cover cellular structures, physiology, genetics, taxonomy, and ecology. Medical microbiology and immunology are included in the context of microbial ecology. Eukaryotic micro-organisms and cells in culture are discussed, but emphasis is placed on prokaryotes and viruses. (Helling, Douthit, and Neidhardt)

411. Introductory Biochemistry. Biol. 105 or 112 (or the equivalent); and Math. 113 or 115; and organic chemistry and physics. No credit is granted to those who have completed Biol. Chem. 415. (4). (NS).

The major objective of this course is to provide upper level undergraduates and beginning graduate students in biology, physiology, cellular and molecular biology, pharmacy, biological chemistry, pharmacology, toxicology, nutrition, physical education, microbiology, bioengineering, and other related areas of biology with an appreciation of the molecular aspects basic to metabolism in plants and animals. Emphasis is placed upon the physiological and dynamic rather than upon the morphological or structural aspects of molecular biology. Biochemistry is defined in the broad sense, i.e., that organizational level of biology as described in molecular or chemical terms. This course is directed toward those contemplating a career in some aspect of experimental biology, including medicine, dentistry, and other professional areas. The general subject matter includes amino acids, structures of protein, enzymes, carbohydrates, lipids, energetics, and the basic metabolism of biological systems. The course is taught according to the methods of the Keller Plan, i.e., it is a self-paced, personalized system of instruction. Students interact according to their own schedules with undergraduate proctors chosen according to interest and ability to teach biochemistry to undergraduates. The course is divided into logical units of material, and students are expected to master the content of each unit. Upon the student's satisfaction that the unit material has been mastered, the student requests a quiz from a proctor. Upon successful completion of material on the quiz, the student is permitted to continue to the material of the next unit. Grades are assigned according to number of units successfully completed by the end of the term, plus a factor derived from a combination of the midterm and final exams. Each quiz is graded immediately upon its completion by both the proctor and the student. This system is designed to take into consideration different rates of individual learning as well as to eliminate unhealthy competition among students. Proctors are available to help students approximately 60 hours per week. Several lectures dealing with biochemical topics are given by the instructor. Material covered in these lectures represents an extension of information in the course and is not the subject of examination. (Beyer)

412. Teaching Biochemistry by the Keller Plan. Biol. 411 and permission of instructor. May not be included in any of the Biological Sciences concentration programs. (3). (NS). (TUTORIAL).

Biology 412 adheres to the old Chinese proverb: "I hear and I forget. I see and I remember. I do and I understand." Undergraduates who previously have taken an introductory biochemistry course act as proctors (tutors, TA's) for students currently taking Introductory Biochemistry (Biology 411). Six hours per week (twelve hours in the Spring half-term) are spent helping and quizzing Biology 411 students. In addition, proctors each provide two mastery level, multi-choice questions for each course unit (30 total) from which the instructor constructs the final examination and midterm examination for both Biology 411 and 412. Proctors also prepare a report on a biochemical discovery which they present to their peers, the 411 students, and the instructor. The major roles of the proctors are to examine the students on their mastery of unit material and to help the student requiring explanation supplementary to the textbook. At the completion of an instructor-generated written quiz, the student and proctor grade the quiz together. The proctor asks the student additional verbal questions generated by the proctor. The proctor passes a student when, and if, the proctor feels the student has mastered the unit material. Student-proctor interactions are evaluated by the students. The proctors are graded on the basis of the quality of their final and midterm examination questions, their biochemical discovery session presentations, and their grades on the midterm and final examination. Proctors learn considerable biochemistry by repeated teachings of unit materials and, in addition, profit from their experience as teachers and evaluators. (Beyer)

415. Lectures in Cell and Molecular Biology. Eight credits of biology, Biol. 411 or the equivalent, and organic chemistry; or permission of instructor. Students with credit for Biol. 320 must obtain permission of instructor. (4). (NS).

This lecture course provides in-depth analysis of the molecular basis of function in living cells. Topics covered will include: transcription, gene expression, chromatin structure, DNA replication, and cell cycle; ribosomes and translation; intracellular transport and secretion; membrane structure and function; bioenergetics in chloroplasts, mitochondria, and prokaryotes; lysosomes and peroxisomes; organelle biogenesis; cytoskeleton, motility; and a survey of methods for studying these topics. Emphasis on the interpretation of experimental data is heavy. There will be two exams (TH 7-9) and a final exam. Questions should be addressed to Ms. Crandall, 2083 Nat. Sci. (Bender, Frasch, Pringle)

416. Laboratory in Cell and Molecular Biology. Concurrent enrollment in Biol. 415 and permission of instructor. No credit is granted to those who have completed Biol. Chem. 416 or 516. (3). (NS).

To familiarize the student with modern laboratory technique involved in the analysis of cell structure and function is the course objective. The course deals with the theoretical and practical aspects of subcellular analysis. Specific experiments have been selected to coordinate with the lectures of Biology 415. The course illustrates certain techniques: cell fractionation, enzyme assay, identification of subcellular functional units, RNA and protein synthesis, mitochondrial and chloroplast function. There will be short lab quizzes and problem sets given. Course grades will be determined based on three major lab reports (written in a format typical of manuscripts submitted for publication in scientific journals), five short reports and two quizzes. For permission, inquire in room 2083 Natural Science. (Bender)

424. Cell and Developmental Genetics. Biol. 305; a course in developmental biology is helpful but not required. (2-3). (NS).

This course is an in-depth analysis of current information on gene control of developmental processes in multicellular organisms. Stress is placed on reading articles in scientific journals; no textbook is used. For each topic covered in lecture, a list of references including one or two key review papers is provided. Students are encouraged to read one or more of these papers. No examinations; student evaluation is based on two term papers, one being an extensive analysis of a topic covered in the lectures and the other a compilation of short summaries of the papers read during the term. Students electing the course for 3 credits are required to present a seminar. (Rizki)

471. Population and Community Ecology. A course in ecology. (3).

Current ecological theory and research is examined in depth. Topics include the logic of hypothesis testing, the maintenance of species diversity, the roles of competition, predation, mutualism, and environmental heterogeneity in ecological systems, and the analysis of population growth and fluctuations. A general background in ecology is required. This course complements Biology 470, Evolutionary Ecology. Short papers and a term paper are required. Readings are from current literature. There are two 1-hour lectures and one 2-hour discussion per week. (Rathcke)

472/Nat. Res. 416. Ecology of Managed Populations and Communities. Two terms of calculus and one term of statistics recommended. (4). (Excl).

The study of the dynamics of single species populations and systems of multi-species populations is examined. This is accomplished by reviewing the theoretical explanations for various topics and comparing these predictions with observations and experiments with animal and plant populations. Topics covered include population growth and its limiting factors (resource acquisition, life history patterns, habitat use, and social structure), competition, predation, population cycles, food web structure, island biogeography, determinants of species diversity, and the stability and persistence of assemblages of populations. Because the theoretical development of these topics depends upon mathematics, students will find experiences with introductory calculus useful, and basic statistical knowledge is useful in understanding the comparison of observed plant and animal populations with the theoretical predictions. The course consists of three one-hour lectures, a lab experiment requiring one hour and a discussion group for one-two hours each week. Students are evaluated on the basis of two hourly exams, a term paper, weekly short lab reports and participation in the discussion group. (Belovsky)

494. Biophysical Chemistry. Biol. 411 and Math. 114; or the equivalent. (3). (NS).

This course is designed to give students in the life sciences a background in physical chemistry as applied to biological systems and biological instrumentation. Particular aspects of thermodynamics, kinetics, and statistical mechanics are reviewed with examples drawn from enzyme folding and catalysis. The applications of physical chemistry which are discussed include the role of non-covalent bonds in the stability and folding of proteins and nucleic acids, the role of entropy in the polymerization of proteins, the nature of specific and non-specific interactions, the energetics of cellular transport, DNA supercoiling, electrophoresis, ultracentrifugation, the use of fluorescence in cell biology, the principles of light and electron microscopy, and the principles of the detection of radiation by photographic and scintillation techniques. Ten graded problem sets and four examinations will be given. (Langmore)

505/Micro. 505. Pathogenic Microorganisms. A course in general microbiology and biological chemistry. Open to undergraduate and graduate students. (3). (NS).

See Microbiology 505 for description. (Freter)

527. Experimental Limnology. Biol. 443 or permission of instructor. (3).

Experimental Limnology is our main advanced limnology course. Its primary purpose is to explore modern limnology with the aid of the current literature published in scientific journals. This year the course will focus on the structure of aquatic ecosystems. We will discuss food chains, community structure, and trophic-dynamics. Weekly lectures and discussions will treat the ecological relationships of organisms at each trophic level from Decomposers (bacteria) to Top Carnivores (insects, fish). Each meeting will consist of a lecture (informal) designed to introduce the topic that will be discussed the following week and a discussion related to the topic introduced the previous week. Students are expected to spend the week prior to each discussion reading relevant papers that will be placed on reserve in the library and any other useful materials. (Kilham)

575. Biological Electron Microscopy. Sixteen credits of biology or graduate standing, and permission of instructor. (4).

The objective of this course is to teach basic techniques applied in biological electron microscopy. The following topics are taught: tissue exposure, fixation and fixatives, embedding and embedding media, sectioning, staining methods, the use of the transmission electron microscope, taking photographs with the electron microscope, and printing and darkroom techniques. The theoretical aspects of these topics are covered in lectures. The practical part is taught in the laboratory and there are discussions of electron micrographs taken by students. The students are required to do some additional practicing in the laboratory (about 14 hours a week). There is a midterm laboratory practical exam and a lecture exam on the use of the electron microscope and its theory. At the end of the term students submit a report of the project they were working on and a 10x14" high quality electron micrograph of their own material. These assignments form the basis for student evaluation. There is no special background necessary, although some knowledge of electronics and histology is helpful. Two textbooks are used in the course: Meek, Practical Electron Microscopy for Biologists; and Hayat, Principles and Techniques of Electron Microscopy, Volume I. (Baic)

Courses in Botany (Division 331)

102. Practical Botany. (4). (NS).

This course aims to teach the techniques for successfully growing and propagating plants and the principles of botanical science upon which they are based. Students are also introduced to the various ways in which the knowledge of plants and their use by the lay person can enhance the quality of life. The environmental factors important in plant growth, particularly light, temperature, water, and soil will be studied. Students will gain practical experience in such applied botanical techniques as the following: preparation of soils and artificial growth media; use of fertilizers; propagation of plants by cuttings, layering, division, bulbs, grafting, and seed; methods of pruning, plant breeding, pest and disease control; preparation of terraria, hanging baskets, and bonsai; the use of plants in landscaping, and the ecology and management of natural areas; and the care and development of living plant collections. Students will be expected to learn to recognize a selected group of indoor and outdoor garden plants, edible wild plants, and common poisonous species. Field trips will include a visit to a commercial greenhouse and an estate garden. Two lecture-discussion periods, and six hours of laboratory per week. Discussions and laboratories are held at the Botanical Gardens, with bus service provided. (Steiner)

190. Plants, People, and Environment. High school biology and chemistry. (3). (NS).

Botany 190 is divided into three basic sections: (1) plants, their way of life, and uses by people; (2) probing the ecological nature of our environment in natural, agricultural, and urban ecosystems; and (3) solutions to and constructive action for our environmental problems. We cover such topics as wild edible foods, the pros and cons of the green revolution, growing and maintaining your own plants, drug and medicinal plants, alternative means of pest control, alternative energy sources, new ideas for home and urban landscapes, natural areas and their preservation, and wild and endangered species of plants. We have a natural foods dinner prepared by the students. Throughout the course, students present oral environmental alerts on specific environmental problems and solutions to them. Grade evaluation is based on three midterms and one environmental alert (written or oral). (Kaufman)

275. Introduction to Plant Development. Biol. 105 or 112; or the equivalent. (4). (NS).

For students interested in how plants grow, this course presents an integrated structural and functional approach to plant development. Topics studied include cell biology and cellular mechanics of plant growth, organogenesis and differentiation with emphasis on controls, particularly hormonal and environmental. The course will provide a basis for understanding the natural history and some practical aspects of plant life. Students attend two one-hour lectures, a one-hour discussion session, and three hours of laboratory each week. The lab will provide experience with both whole plants and axenic tissue cultures. (Nooden)

422. Systematic Botany. Biol. 105 or Biol. 112 and 114 (or the equivalent), or Bot. 207; or permission of instructor. (4). (NS).

The diversity of higher plants is taught with lectures, color projection slides, specimens, living plants, and laboratory discussions. Emphasis is on the level of orders, families and genera, temperate as well as tropical, so that students can make themselves familiar with plants in any part of the world. The course focuses mainly on the flowering plants because of their dominant role on the earth, but gymnosperms and pteridophytes are studied too. The phylogeny of vascular plants provides the framework. In angiosperms hypothetical ancestral types are discussed and various lines are analysed, e.g., the pinks (Caryophillidae), roses (Rosidae), wind-pollinated trees (Hamamelidae), lilies (Liliidae), and so on. Related subjects, such as habitats of plants, geography, biosystematics, cladistics and floral biology are presented in special lectures. A major component of the science of botany, systematics is considered essential to training plant scientists and botany majors. However, the course is also elected by biology majors, zoologists, foresters, ecologists and ethnobotanists. Some individuals take the course merely because they enjoy plants and wish to learn about them, including students with backgrounds as diverse as engineering and city planning. The methods of instruction include lecture and laboratory, the latter including demonstrations and discussions. There are two midterms, a final, and numerous small lab quizzes. Various texts are recommended for students with special interests, but only two are required. They are Davis, P.H. and J. Cullen, The Identification of Flowering Plant Families (Cambridge University Press) and Wood, C.E., Jr. A Student's Atlas of Flowering Plants (Harper and Row). (Wagner)

425. Phytogeography. Bot. 422 or permission of instructor. (3). (NS).

Phytogeography, the study of plant distribution patterns and the processes of their development, draws upon evidence from diverse areas of the life sciences and the earth sciences. It is currently an arena of lively debate because of its contributions to topics such as plate tectonic theory, episodes of catastrophic extinctions, and changes of climate. Lectures (about two-thirds of the meetings) introduce topics from which students may choose questions to pursue in detail for class discussions and in the term paper. The textbook is Biogeography (1983) by Brown and Gibson, and some additional readings will be assigned. There are a midterm hour exam and a final exam. (Benninghoff)

437. Anatomy of Vascular Plants. Biol. 105 or Biol. 112 (or the equivalent), or Bot. 207. (4). (NS).

This most interesting course is basic to an understanding of plant biology and important for anyone planning to enter anthropology, archaeology, biology, botany, ecology, forestry and other areas of natural resources, horticulture, plant physiology, plant pathology, and others. The course deals with the nature of the cells, tissues, and organs of the plant body, the sites of their inititation, patterns of development, and the relationship between their structure and function. In other words, one will learn in detail about the internal structure of plants and how they grow. We also consider the evolution of plant structure. The course will consist of two well-illustrated lectures and two laboratories each week in which we shall study both prepared slides and a large quantity of living material. Botany 437 satisfies a requirement of both the Biology and Botany concentration programs. Student understanding of the subject matter will be evaluated by two lecture tests, two laboratory tests and a final exam. (Beck)

472. Plant Population Biology. A course in ecology. (3). (Excl).

The course will cover empirical and theoretical approaches to the ecology of plant populations and communities. Topics include plant life history patterns, breeding systems, ecotypic differentiation, population dynamics, mechanisms and consequences of intraspecific and interspecific competition, interaction of plants with other trophic levels, plant distribution patterns, and community organization. Although the emphasis will be on natural populations, managed systems will also be considered. A course in ecology is required background. Grades will be based on a literature review paper, midterm, and final examination. Although there will be a textbook, emphasis will be placed on reading primary sources. The format of the course will be lecture and discussion. (Goldberg)

479. Plant Cell and Tissue Culture. Eight hours in biology; at least junior standing. (4). (NS).

This course deals with contemporary methods and results of studies on plant protoplast, cell and tissue cultures. The lectures cover such topics as (1) how plant cells, tissues, and organs are cultured, (2) induction of roots and shoots in tissue cultures, (3) regeneration of whole plants from single cells, (4) protoplast isolation and fusion of protoplasts, (5) somatic cell hybridization in plants, (6) genetic engineering with plant protoplasts, cell, and tissue cultures, (7) applications of plant cell and tissue culture in plant breeding, forestry, crop production, and horticulture, (8) uses of plant cell and tissue cultures to produce secondary compounds of interest in medicine and pharmacology, (9) uses of plant cell and tissue cultures in the U.S. Space Biology Program under NASA, and (10) uses of plant cell and tissue cultures to save threatened and endangered plant species from extinction. The lab deals with the primary techniques of plant cell and tissue culture isolation of protoplasts, mericloning, establishing tissue cultures and cell suspension cultures, somatic embryogenesis, somatic cell hybridization, anther and pollen cultures to get haploids, production of secondary metabolites in cell cultures, quantitation of tissue culture procedures, induction of vascular differentiation in tissue cultures, and sterile techniques and media preparation. Students will have an opportunity to do an independent project in the lab. (Kaufman)

Courses in Zoology (Division 499)

130. Animal Behavior. (3). (NS).

The course is an introduction to the behavior of animals in their natural environment. Social behavior of birds, mammals, and insects is emphasized. Topics include: the environment as animals perceive it, natural selection and adaptations, development of behavior, communication, sexual cooperation and mate choice, social behavior of animals in groups, the importance of family relationships, and the evolution of traditions. The course objectives are to gain a background in the natural behavior of animals and to explain the evolution of behavior. By the end of the course you should be able to: 1) explain how biologists explore the sensory world of animals, 2) evaluate the evidence that behavior is shaped by natural selection, 3) recognize the interaction between environmental modification and genetic determinism, and 4) explain sexual behavior, aggressive behavior, and social interactions in terms of evolution. The course consists of lectures, readings, slides and movies. Grades are based on two midterms and a final exam. The first midterm is 15% of the total grade, the second 30%, the final 55%. Exams are multiple choice. Texts: Animal Behaviour, by A. Manning; An Introduction to Behavioural Ecology, by J.R. Krebs and N.B. Davies; and one additional book. (Payne)

325. Principles of Animal Physiology: Lecture. Biol. 112 and 114 (or the equivalent) and a year of chemistry. (3). (NS).

This course is an introduction to the physiological view of animals and emphasizes zoological rather than human aspects. The course uses evidence from different groups of organisms to identify the general principles of functional mechanisms. It also considers variations in these mechanisms as related to the requirements of the animals but does not attempt a phylogenetic survey. The course is intended for concentrators and pre-medical students in their sophomore, junior, or senior years. Prospective animal physiologists should consider electing Zoology 421, 422, or 428 - these courses cover more limited areas in greater depth. The subject matter includes metabolism and temperature regulation, water and ion balance and excretion, digestion, respiration and circulation, and the nervous system and integration. There are three one-hour lectures a week, three one-hour examinations, and a final exam. Supplementary reading in the undergraduate library is recommended. (Hume)

326. Animal Physiology Laboratory. Concurrent enrollment in Zool. 325. (1). (NS).

The exercises in laboratory deal (usually concurrently) with topics covered in the lecture. The laboratory meets for one four-hour session a week. A report on every exercise is required. Most reports are short (two to three pages) and attempt to answer specific questions. Two full-length reports are also required. Students choose which exercises to write up in full. Zoology 326 must be taken concurrently with Zoology 325. Students who have taken or intend at a later date to take Zoology 325 will not be admitted to Zoology 326. (Hume)

422. Introduction to Neurobiology. Biol. 112 and 114 (or the equivalent), one year of chemistry, and one year of physics. (3). (NS).

An introduction to neural function, including such topics as action potentials, synaptic phenomena, sensory systems, motor output, neurohormonal integration, development, memory, etc. (Oakley)

423. Laboratory in Neurobiology. Prior or concurrent enrollment in Zool. 422 or equivalent, and permission of instructor. (2). (NS).

Anatomy and physiology of invertebrate and vertebrate nervous systems, including examination of various sensory and motor systems. Electrophysiological techniques are routinely used. (Oakley)

450. Biology of Amphibians and Reptiles. Biol. 105 or 114. (4). (NS).

Lectures on the evolution, behavior, ecology, and life history of amphibians and reptiles. Laboratory exercises and field trips emphasize identification, life history, adaptations, and field methods. (Nussbaum)

454. Zoogeography. Biol. 282, 351, or equivalent, and permission of instructor. (3). (Excl).

Discussion of the major features that govern the distribution and abundance of animals, using both empirical and theoretical approaches. Major topics include: island biogeography; aereography; geographical ecology; methodology in zoogeographic inference; and conservation biogeography. Students should have taken a course in evolution or ecology previously. Evaluation will be made on the basis of two exams, a term paper, and oral majority. (Heaney)

456/Nat. Res. 409. Ecology of Fishes. Prior ecology courses. (4). (Excl).

Physiological, behavioral, and numerical responses of fish to biotic and abiotic factors. The relationships between fish and the physical, chemical and biological parameters of the major habitat types is emphasized, especially in regards to the adaptations of fish for survival under these different constraints. It is recommended that students have a course in general ecology before taking this course. Student evaluation consists of three lecture exams, one lab exam and a review of their lab notebooks. The format is three hours of lecture and one three-hour lab per week. (Diana, G. Smith)

480. Biological Ultrastructure and Histogenesis. Eight credits of biology. (3). (NS).

The subject matter of this course is the differentiation of cells and tissues from molecular to microscopic levels of organization. Emphasis is on histogenesis in vertebrates, but relevant work on invertebrate and plant organisms is also considered. The course includes results obtained by a variety of analytical techniques, including x-ray diffraction, electron microscopy, autoradiography, cytochemistry, histological staining, and light microscopy. The aim of the course is to integrate structural aspects of cell and molecular biology, developmental biology, and histology. The following topics are included: techniques of light and electron microscopy; origin of macromolecules; viruses; development of cell organelles and inclusions; secretion of cell products; cell locomotion; cell division; gametogenesis and early embryology; histogenesis of cell and tissue types in vertebrate organ systems. Junior standing with at least eight hours of biology is required. Previous courses in development, histology, cell biology, or electron microscopy would be helpful. Course organization: three lectures per week; two midterm examinations and a final. Textbook of Histology by Fawcett and Bloom is a recommended reference. Reading lists of books and published papers are provided. Lectures are illustrated with slides and interpretive drawings. (Kemp)


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