415. Introductory Biochemistry. Two terms of organic chemistry equivalent to Chem. 225 and 226. No credit is granted to those who have completed Biol. 411. (3-4). (Excl).
This is a one term course in biochemistry. Biochemistry is essentially the identification of the characteristics of living matter. Specifically the course will cover the biochemistry of the living state, the chemistry of biomolecules, energy transformations and chemical reactions in living cells; function of the immune system and action of hormones; self-regulation and self-replication of living organisms. The course begins with a set of 16 objectives in the form of questions, and at the end these objectives are reexamined. The main text is BIOCHEMISTRY, 3rd ed. by Stryer. Some topics on molecular biology are also covered by MOLECULAR BIOLOGY OF THE GENE, 3rd ed., by Watson. The course is basically a lecture course with handouts provided for emphasis. Three hourly exams and a final examination will be used to evaluate student performance. It is possible to obtain a fourth credit hour by attending an extra series of lectures and preparing a research paper. [Cost:3] [WL:3] (Zand, Dekker, and Uhler)
416. Introductory Biochemistry Laboratory. Quantitative analysis (e.g., Chemistry 197 or 348); prior or concurrent election of Biol. Chem. 415. No credit is granted to those who have completed Biol. 429 or Biol. Chem. 516. (3). (Excl).
The goal of this laboratory-lecture course is to introduce students to modern biochemical techniques involving the separation and isolation of large molecules (proteins, DNA, RNA) and small molecules. An enzyme is isolated and purified and then used to study enzyme kinetics; and through this process students are introduced to spectrophotometric analysis, chromatographic (paper, columns, thin-layer) separations, disc gel electrophoresis and other techniques. Thermodynamic parameters are calculated from an experiment using alcohol dehydrogenase. Students are also introduced to the use of radioisotopes in metabolic studies and radioimmunoassay. Laboratory experiments dealing with the use of molecular biology/DNA manipulations to facilitate biochemical analysis are also covered. Students are expected to be familiar with simple chemical calculations at a level equivalent to that acquired through an introductory level college chemistry course. Previous laboratory work, especially Chemistry 346 or its equivalent is useful. This course is elected by biochemists and chemists and no distinction is made between undergraduates (about three-fourths) and graduates (about one-fourth) in assigning final grades in the course. The course is not related to or equivalent to Biology 429. [Cost:2] [WL:4] (Thiele and McCann)
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