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Winter Academic Term 2003 Course Guide

Note: You must establish a session for Winter Academic Term 2003 on wolverineaccess.umich.edu in order to use the link "Check Times, Location, and Availability". Once your session is established, the links will function.

Courses in Biophysics


This page was created at 11:37 AM on Thu, Feb 6, 2003.

Winter Academic Term, 2003 (January 6 - April 25)

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BIOPHYS 520 / CHEM 520. Biophysical Chemistry I.

Section 001.

Instructor(s): Erik R P Zuiderweg (zuiderwe@umich.edu)

Prerequisites & Distribution: CHEM 463, BIOLCHEM 415, or CHEM 420; permission of course director. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

This course is the first of a two-term Biophysical Chemistry series BIOPHYS 520/521, but it can be taken as stand-alone course as well. BIOPHYS 520 will introduce and explain the physicochemical properties of biological macromolcules and their complexes, mostly in solution. The course offeres an overview of protein and nucleic acid structures. Intra- and inter-molecular forces, helix-coil transitions, and protein folding will be treated in a thermodynamical context.

Thermodynamics of solutions, configurational statistics, ligand interactions, multi-site interactions, and cooperativity are treated in depth. Kinetics and thermodynamics of protein-ligand binding are discussed. The role of dynamics in protein function is introduced.

Currently, biophysical, biochemical, and pharmacochemical research literature is full with papers interpreting the properties of biological macromolecules on the the basis of their three-dimensional structure. This course will expand on that concept by offering a rigorous background in energetics, folding, interactions, and dynamics. As such the course is important to any student who has to deal with the concepts of biomolecular function and structure such as biochemists, molecular biophysicists, mathematical biologists, and molecular pharmacologists. This course will also serve as a basis for the graduate student who will be specializing in any of these topics for thesis research.

Instructional material: Van Holde, Physical Biochemistry, 1998 and course packs.

Evaluation: homework (40%), midterm exam (30%) and final exam (30%).

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

BIOPHYS 521 / CHEM 521. Biophysical Chemistry II.

Section 001.

Instructor(s): Robert Zand

Prerequisites & Distribution: CHEM 461, BIOLCHEM 415, and CHEM 430; and permission of course director. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

This course is team-taught and is the second of a two-term biophysical chemistry series, BIOPHYS 520/521, but it can be taken as a stand-alone course. Biophysics 521 provides an overview of the theory and application of spectroscopical techniques of UV/Vis, IR, Flourescence, Single Molecule Detection, CD, and NMR. Other topics covered include X-ray crystallography, computational methods, light scattering, ultracentrifugation. When possible, hands-on opportunities in applying some of these techniques will be offered.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

Graduate Course Listings for BIOPHYS.


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This page was created at 11:37 AM on Thu, Feb 6, 2003.


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