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Winter Academic Term 2003 Course Guide

Note: You must establish a session for Winter Academic Term 2003 on wolverineaccess.umich.edu in order to use the link "Check Times, Location, and Availability". Once your session is established, the links will function.

Courses in Biophysics


This page was created at 2:44 PM on Thu, Oct 17, 2002.

Winter Academic Term, 2003 (January 6 - April 25)

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BIOPHYS 520 / CHEM 520. Biophysical Chemistry I.

Section 001.

Instructor(s): Erik R P Zuiderweg (zuiderwe@umich.edu)

Prerequisites & Distribution: CHEM 463, BIOLCHEM 415, or CHEM 420; permission of course director. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

This course is the first of a two-term Biophysical Chemistry series 520/521, but it can be taken as stand-alone course as well. The course offers an overview of protein, nucleic acid, lipid and carbohydrate structures. Intra- and inter-molecular forces, helix-coil transitions, and protein folding will be treated in a thermodynamical context. Thermodynamics of solutions, configurational statistics, ligand interactions, multi-site interactions, and cooperativity are treated in depth. Kinetics of protein-ligand binding, including electron transfer and ligand diffusion are discussed. Chemistry 520 will introduce and explain the physicochemical properties of biological macromolecules and their complexes, mostly in solution.

Currently, biophysical, biochemical and pharmacochemical research literature is full with papers interpreting the properties of biological macromolecules on the the basis of their three-dimensional structure. This course will expand on that concept by offering a rigorous background in energetics, folding, interactions, and dynamics. As such the course is important to any student who has to deal with the concepts of biomolecular function and structure such as biochemists, biophysicists, mathematical biologists, and molecular pharmacologists. This course will also serve as a basis for the graduate student who will be specializing in any of these topics for thesis research. Molecular dynamics will be introduced. Instructional material: Cantor and Shimmel, Biophysical Chemistry, Part I and III and Creighton, Proteins, Structures and Molecular Properties. Evaluation: homework (50%), midterm exam (20%) and final exam (30%).

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

BIOPHYS 521 / CHEM 521. Biophysical Chemistry II.

Section 001.

Instructor(s): Robert Zand

Prerequisites & Distribution: CHEM 461, BIOLCHEM 415, and CHEM 430; and permission of course director. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

This course is the second of a two term biophysical chemistry series, Biophysics 520/521. The course can be taken without taking Biophysics 520. Biophysics 521 gives an overview of the spectroscopical techniques UV/Vis, IR, Raman, CD Mossbauer, Exafs, EPR and ESEEM. Structure determination by X-ray diffraction and two-dimensional will be treated in fair detail. Stopped-flow kinetics techniques are introduced. Electron, light and scanning microscopies and optical tweezers will be introduced. Ultracentrifugation, plasmon, resonance, mass spectrometry and calorimetry will be discussed. Lab techniques such as chromatography, electrophoresis, protein expression and site-directed mutagenesis will be introduced.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

Graduate Course Listings for BIOPHYS.


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