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Winter Academic Term 2003 Course Guide

Note: You must establish a session for Winter Academic Term 2003 on wolverineaccess.umich.edu in order to use the link "Check Times, Location, and Availability". Once your session is established, the links will function.

Courses in Molecular, Cellular, and Developmental Biology


This page was created at 3:01 PM on Thu, Oct 17, 2002.

Winter Academic Term, 2003 (January 6 - April 25)

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MCDB 300(BIOLOGY 300). Undergraduate Research.

Instructor(s):

Prerequisites & Distribution: Eight credits of biology and 3.0 grade point average in science; permission of faculty member in biology. (1-3). (Excl). (BS). (INDEPENDENT). May be repeated for a maximum of 9 credits.

Credits: (1-3).

Course Homepage: No homepage submitted.

MCDB 300 intended primarily for juniors, including Honors students, who wish to pursue independent research or study at an intermediate level in an area of biological science. Students may ask an appropriate faculty member in the Department of Biology to direct the research project and supervise related readings. The project may take the form of an investigation of new problems in the field or laboratory, a detailed investigation of primary sources (a literature survey), development of new procedures or programs, design of a classroom experiment, etc. A final paper is required and must be approved by the research advisor.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of Department

MCDB 302(BIOLOGY 302). Teaching Experience for Undergraduates.

Instructor(s):

Prerequisites & Distribution: Permission of instructor. (1-3). (Excl). May not be included in any of the Biological Sciences concentration programs. (EXPERIENTIAL). May not be repeated for credit.

Credits: (1-3).

Course Homepage: No homepage submitted.

Undergraduates participating in this course are responsible for:

  1. aiding regularly assigned Graduate Student Instructors;
  2. providing tutorial help for undergraduates enrolled in the course;
  3. meeting regularly with discussion and laboratory sessions; and
  4. participating with Graduate Student Instructors in instructional activities.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of Instructor

MCDB 306(BIOLOGY 306). Introductory Genetics Laboratory.

Section 001.

Instructor(s): Santhadevi Jeyabalan (sjeyabal@umich.edu)

Prerequisites & Distribution: Prior or concurrent enrollment in BIOLOGY 305. (3). (Excl). (BS). Satisfies a Biology laboratory requirement. Laboratory fee ($70) required. May not be repeated for credit.

Credits: (3).

Lab Fee: Laboratory fee ($70) required.

Course Homepage: No homepage submitted.

This course provides students with laboratory experience on basic genetic principles. Students will analyze patterns of inheritance, gene interaction, linkage relationship, and genetic mapping of unknown mutants of Drosophila through a series of genetic crosses. By using molecular techniques such as Polymerase Chain Reaction (PCR) and gel electrophoresis, mutations in Caenorhabditis elegans will be mapped to chromosomal locations. The experiments in microbial genetics include mapping by conjugation in E. coli, recombination analysis by transduction using bacteria and phage, and complementation tests on "his" mutants of yeast. Experiments in Human Population Genetics include calculating allelic frequencies of PTC tasting in the class. Students will also be doing DNA fingerprinting of a VNTR locus using their own squamous epithelial cells. A computer exercise on Bioinformatics is included. One hour lecture on Mondays 1-2 PM and one three-hour lab are scheduled each week; additional 3-4 hours of lab time per week is expected at irregular times. Students are expected to write one formal lab report and to keep a complete and accurate record of all results and analyses in a bound lab notebook. There are two tests given during the term. Students will need to purchase a lab manual.

Check Times, Location, and Availability Cost: 1 Waitlist Code: 1

MCDB 308(BIOLOGY 308). Developmental Biology Laboratory.

Section 001.

Instructor(s): Santhadevi Jeyabalan (sjeyabal@umich.edu)

Prerequisites & Distribution: Prior or concurrent enrollment in MCDB 307. (3). (Excl). (BS). Satisfies a Biology laboratory requirement. Laboratory fee ($45) required. May not be repeated for credit.

Credits: (3).

Lab Fee: Laboratory fee ($45) required.

Course Homepage: No homepage submitted.

BIOLOGY 208 or MCDB 307 or permission of the instructor are required as prerequisites for this course.

This course provides students with the opportunity to study first hand the development of a number of live vertebrate and invertebrate embryos, specifically sea urchin, amphibian, and chick embryos. In addition to observation of normal embryogenesis, students perform several of the experimental analyses which have contributed to a basic understanding of developmental processes.

Exercises focus on fertilization, developmental morphology, induction, determination and differentiation of various tissues, metamorphosis, and regeneration. Students perform 'in vitro' culturing of embryonic tissues, chemical and surgical manipulation of embryos. In addition to one hour of lecture and one scheduled three-hour laboratory session each week, students are expected to spend about three additional hours in the laboratory each week. Grades are based on three laboratory tests, a term paper, and lab notebook evaluation. Maintenance of a lab notebook for a complete and accurate record of observations and experimental results is required. There is a required lab manual.

Textbook: Patterns and Experiments in Developmental Biology by Leland G. Johnson.

Check Times, Location, and Availability Cost: 2 Waitlist Code: No Data Given.

MCDB 321(BIOLOGY 321). Introductory Plant Physiology Lectures.

Section 001.

Instructor(s): Jianming Li (jian@umich.edu)

Prerequisites & Distribution: BIOLOGY 162; college physics recommended. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

This course is offered for students who are curious about how plants do the things they do in their everyday life. The main objective of the course is to provide students with an overview of plant molecular and physiological processes and how they are influenced by environmental factors. Major topics will include plant and cell architecture, plant water relations and mineral nutrition, photosynthesis and cellular respiration, plant growth and development, plant hormone and their signal transduction, plant defense and stress physiology. The course material will be presented in a lecture format, but discussion and questions are very much encouraged. There will be three one and one-half hour tests in the course. Students must purchase the assigned textbook.

Check Times, Location, and Availability Cost: 3 Waitlist Code: 1

MCDB 400(BIOLOGY 400). Advanced Research.

Instructor(s):

Prerequisites & Distribution: 12 credits of biology, 3.0 average in science, and permission of faculty member in biology. (1-3). (Excl). (BS). (INDEPENDENT). May be repeated for a maximum of 9 credits.

Credits: (1-3).

Course Homepage: No homepage submitted.

Intended for those engaged in original research at an advanced level. This course number is most frequently elected by senior Honors students who have completed MCDB 300 and who are completing their research and writing their thesis. A final paper is required. (Refer to the description of MCDB 300 for more information.)

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of Department

MCDB 413(BIOLOGY 413). Plant Molecular Biology Laboratory.

Section 001.

Instructor(s): Eran Pichersky (lelx@umich.edu)

Prerequisites & Distribution: BIOLOGY 310 or 311, or BIOLCHEM 415; and BIOLOGY 305. (3). (Excl). (BS). Satisfies a Biology laboratory requirement. Laboratory fee ($70) required. May not be repeated for credit.

Credits: (3).

Lab Fee: Laboratory fee ($70) required.

Course Homepage: No homepage submitted.

This is a project lab in which students learn to identify and analyze plant genes and gene products using the latest techniques of molecular biology. Emphasis will be on genes encoding unique plant characteristics. Students will first isolate genes from DNA libraries of various plant species. They will then analyze the sequence of genes they have isolated by DNA sequencing, and will characterize their copy number and expression levels by various techniques such as Southern blots, Northern blots, etc. The genes will then be manipulated to produce the gene products (i.e., proteins) in a bacterial system.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 1

MCDB 428(BIOLOGY 428). Cell Biology.

Section 001 MIDTERM EXAMS WILL BE HELD TUES, FEB 4, AND MAR 18, 6-8 PM.

Instructor(s): James Bardwell (jbardwel@umich.edu) , Kenneth M Cadigan (cadigan@umich.edu)

Prerequisites & Distribution: BIOLOGY 305; and BIOLOGY 310 or 311, or BIOLCHEM 415. Students with credit for MCDB 320 must obtain permission of instructor. (4). (Excl). (BS). May not be repeated for credit.

Credits: (4).

Course Homepage: No homepage submitted.

MCDB 428 is designed to provide students with a comprehensive overview of the biology of eukaryotes and prokaryotes at the cellular and molecular level. This course is intended for upper-level undergraduates and graduate students. The information is presented at a level that requires students to integrate information from their other biology, chemistry, and biochemistry courses. Topics include: cell structure and function; cell membranes; intracellular organelles and cytoskeleton; inter- and intra-cellular signaling; cell development and cell cycle. Students will be expected to integrate the scientific data presented in class as well as to read and interpret basic research drawn from the current scientific literature. Grades will be based on four exams and the discussion section. Textbook: Molecular Biology of the Cell by Alberts et al. Garland Science.

Contact jbardwel@umich.edu or cadigan@umich.edu if you have questions regarding the course.

Check Times, Location, and Availability Cost: 2 Waitlist Code: 1

MCDB 429(BIOLOGY 429). Laboratory in Cell and Molecular Biology.

Section 001.

Instructor(s): Kenneth J Balazovich (kbalazo@umich.edu)

Prerequisites & Distribution: MCDB 427 or 428, or concurrent enrollment in MCDB 428. No credit granted to those who have completed or are enrolled in BIOLCHEM 416 or 516. (3). (Excl). (BS). Satisfies a Biology laboratory requirement. Laboratory fee ($70) required. May not be repeated for credit.

Credits: (3).

Lab Fee: Laboratory fee ($70) required.

Course Homepage: No homepage submitted.

This laboratory course encompasses a broad spectrum of common methods and theory essential to Cellular and Molecular Biology concentrations. The one hour lecture each week is used to introduce methodology and techniques that will be encountered in the lab. Two, four-hour weekly lab sessions are arranged in a project-based format. The projects include several kinds of microscopy, cellular organelle isolation, gel electrophoresis, Western bottting, column chromatography and tissue culture, in addition to molecular biology methods such as plasmid construction, transfection, polymerase chain reaction, and Southern blotting. Grades are based on three exams, laboratory quizzes and a semester-long grant proposal project that may be completed individually or in a self-organized group. This course can be used to satisfy requirements for the Cell and Molecular Biology Concentration and the Biology Concentration.

Textbook:
Laboratory DNA Science (Bloom et al.) Mandatory.
Molecular Biology of the Cell (Alberts et al.) Suggested.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 1

MCDB 430(BIOLOGY 430). Molecular Biology of Plants.

Section 001.

Instructor(s): Eran Pichersky (lelx@umich.edu)

Prerequisites & Distribution: BIOLOGY 305; and 310 or 311, or BIOLCHEM 415. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

The topic of this course is major advances in understanding molecular processes in plants, and the contribution of molecular biological techniques to these advances. The course is intended for advanced undergraduates and beginning graduate students. The course will begin with an overview of the basic techniques of plant molecular biology such as cloning and sequencing of DNA, transformation, and analysis of gene expression. We will then examine selected topics in detail, including genome structure and the evolution of genes, proteins, and biochemical pathways, photoreception, photosynthesis and respiration, and the synthesis of secondary products. We will read and then discuss research publications in class. Student performance will be evaluated on the basis of class presentations and participation, and two take-home examinations.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 1

MCDB 435(BIOLOGY 435). Intracellular Trafficking.

Section 001.

Instructor(s): Jesse C Hay (jessehay@umich.edu)

Prerequisites & Distribution: BIOLOGY 305, BIOLOGY 310, 311, or BIOLCHEM 415, and MCDB 428. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

This is an advanced discussion-oriented course covering the latest research in the field of intracellular trafficking. Topics covered include molecular basis of secretion, vesicle transport, protein targeting, molecular motors, and organelle biogenesis. Students will be presented lectures providing them with enough background to understand specific questions and gaps in our knowledge of intracellular trafficking mechanisms. Most of the class time, however, will be spent discussing current research papers from the primary literature. The emphasis will be on the critical evaluation of these studies' experimental approaches, interpretation of data, and conclusions.

This course is intended for students with a serious interest in cell biological research. It is intended for advanced, graduate school-bound undergraduates, and first- and second-year graduate students. There will be two 1.5 hour class periods per week. Students will be assigned problem sets to ensure that they have done the reading before class and have thought sufficiently about the issues involved. The course will also require participation in discussion. In addition, each student will have to present at least one research paper to the class, explain the questions being addressed, techniques, pitfalls, etc.

Check Times, Location, and Availability Cost: 1 Waitlist Code: 1

MCDB 526(BIOLOGY 526) / CHEM 526. Chemical Biology II.

Section 100.

Instructor(s): E Neil G Marsh (nmarsh@umich.edu)

Prerequisites & Distribution: MCDB 525. Prior or concurrent enrollment in CHEM 402 or equivalent. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

See Chemistry 526.100.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: No Data Given.

MCDB 589(BIOLOGY 589). Mechanisms of Microbial Evolution.

Section 001.

Instructor(s): Julian P Adams (julian@umich.edu)

Prerequisites & Distribution: BIOLOGY 305. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

Topics covered include the nature of microbial populations, laboratory populations, mutator loci in clonal populations, and coevolution.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 1

Graduate Course Listings for MCDB.


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This page was created at 3:01 PM on Thu, Oct 17, 2002.


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