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Winter Academic Term 2004 Course Guide

Note: You must establish a session for Winter Academic Term 2004 on wolverineaccess.umich.edu in order to use the link "Check Times, Location, and Availability". Once your session is established, the links will function.

Courses in Molecular, Cellular, and Developmental Biology


This page was created at 7:39 PM on Wed, Jan 21, 2004.

Winter Academic Term, 2004 (January 6 - April 30)


The Department formerly known as Biology divided into two separate departments, EEB (Ecology and Evolutionary Biology) and MCDB (Molecular, Cellular and Developmental Biology). The Interdepartmental Program in Biology (BIOLOGY) is administered jointly by the Department of Ecology and Evolutionary Biology (EEB) and the Department of Molecular, Cellular, and Developmental Biology (MCDB).

Beginning with the Fall 2002 term, there have been some changes in how courses are listed. 100 and 220 - level courses are listed under the subject of BIOLOGY, as are some of the core concentration courses such as Genetics, Biochemistry, and Evolution. Intermediate and upper level courses are listed under EEB or MCDB, depending on the course topics. Students must look under the three subjects to see whether or not a course is being offered.

Those students planning to register for independent research, 300 or 400, will enroll in either MCDB 300 or 400 or EEB 300 or 400, based on their faculty sponsor's departmental affiliation.

Courses in Biology

Courses in Ecology and Evolutionary Biology


MCDB 300(BIOLOGY 300). Undergraduate Research.

Instructor(s):

Prerequisites & Distribution: Eight credits of biology and 3.0 grade point average in science; permission of faculty member. (1-3). (Excl). (BS). (INDEPENDENT). May be repeated for credit for a maximum of 9 credits.

Credits: (1-3).

Course Homepage: No homepage submitted.

MCDB 300 is intended primarily for juniors, including Biology or CMB Honors students, who wish to pursue independent research at an intermediate level in an area of biological science. Students may ask an appropriate faculty member in the Department of Molecular Cellular and Developmental Biology to direct the research project and supervise related readings. Alternatively, students may identify a research advisor in another LS&A department, the UM Medical School, or another unit on the UM campus. Students conducting independent research in such outside units must identify a co-sponsor within the Department of MCDB. Independent research is defined as a laboratory project in which the student will have a say in the design, conduct, and interpretation of experiments. Library research projects and lab projects which are strictly a technical training experience do not qualify for credit as undergraduate research. A final paper is required and must be approved by the research advisor.

The work in this course may continue for two academic terms. A 'Y' grade can be reported at the end of the first term to indicate work in progress. At the end of the second term of MCDB 300, the final grade is posted for both term's elections. Students interested in MCDB 300 should obtain the brochure MCDB Department Policies on Undergraduate Research from the Undergraduate Biology Program Office (1111 Natural Science Bldg).

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of instructor

MCDB 302(BIOLOGY 302). Teaching Experience for Undergraduates.

Instructor(s):

Prerequisites & Distribution: Permission of instructor. (1-3). (Excl). (EXPERIENTIAL). May not be repeated for credit. May not be included in any of the Biological Sciences concentration programs.

Credits: (1-3).

Course Homepage: No homepage submitted.

Undergraduates participating in this course are responsible for:

  1. aiding regularly assigned Graduate Student Instructors;
  2. providing tutorial help for undergraduates enrolled in the course;
  3. meeting regularly with discussion and laboratory sessions; and
  4. participating with Graduate Student Instructors in instructional activities.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of instructor

MCDB 306(BIOLOGY 306). Introductory Genetics Laboratory.

Section 001.

Instructor(s): Santhadevi Jeyabalan (sjeyabal@umich.edu)

Prerequisites & Distribution: Prior or concurrent enrollment in BIOLOGY 305. (3). (Excl). (BS). May not be repeated for credit. Satisfies a Biology laboratory requirement. Laboratory fee ($70) required.

Credits: (3).

Lab Fee: Laboratory fee ($70) required.

Course Homepage: No homepage submitted.

This course provides students with laboratory experience on basic genetic principles. Students will analyze patterns of inheritance, gene interaction, linkage relationship, and genetic mapping of unknown mutants of Drosophila through a series of genetic crosses. By using molecular techniques such as Polymerase Chain Reaction (PCR) and gel electrophoresis, mutations in Caenorhabditis elegans will be mapped to chromosomal locations. The experiments in microbial genetics include mapping by conjugation in E. coli, recombination analysis by transduction using bacteria and phage, and complementation tests on "his" mutants of yeast. Experiments in Human Population Genetics include calculating allelic frequencies of PTC tasting in the class. Students will also be doing DNA fingerprinting of a VNTR locus using their own squamous epithelial cells. A computer exercise on Bioinformatics is included. One hour lecture on Mondays 1-2 PM and one three-hour lab are scheduled each week; additional 3-4 hours of lab time per week is expected at irregular times. Students are expected to write one formal lab report and to keep a complete and accurate record of all results and analyses in a bound lab notebook. There are two tests given during the term. Students will need to purchase from one of the copy centers, a lab manual, MCDB 306 Genetics Laboratory Manual, by Jeyabalan.

Check Times, Location, and Availability Cost: 2 Waitlist Code: 1

MCDB 308(BIOLOGY 308). Developmental Biology Laboratory.

Section 001.

Instructor(s): Santhadevi Jeyabalan (sjeyabal@umich.edu)

Prerequisites & Distribution: Prior or concurrent enrollment in MCDB 307. (3). (Excl). (BS). May not be repeated for credit. Satisfies a Biology laboratory requirement. Laboratory fee ($45) required.

Credits: (3).

Lab Fee: Laboratory fee ($45) required.

Course Homepage: No homepage submitted.

BIOLOGY 208 or MCDB 307 or permission of the instructor are required as prerequisites for this course.

This course provides students with the opportunity to study first hand the development of a number of live vertebrate and invertebrate embryos, specifically sea urchin, amphibian, and chick embryos. In addition to observation of normal embryogenesis, students perform several of the experimental analyses which have contributed to a basic understanding of developmental processes.

Exercises focus on fertilization, developmental morphology, induction, determination and differentiation of various tissues, metamorphosis, and regeneration. Students perform 'in vitro' culturing of embryonic tissues, chemical and surgical manipulation of embryos. In addition to one hour of lecture and one scheduled three-hour laboratory session each week, students are expected to spend about three additional hours in the laboratory each week. Grades are based on two laboratory tests, a term paper with poster presentation, and lab notebook evaluation. Maintenance of a lab notebook for a complete and accurate record of observations and experimental results is required. There is a required lab manual.

Textbook: Patterns and Experiments in Developmental Biology by Leland G. Johnson.

Check Times, Location, and Availability Cost: 2 Waitlist Code: 1

MCDB 400(BIOLOGY 400). Advanced Research.

Instructor(s):

Prerequisites & Distribution: 12 credits of biology, 3.0 average in science, and permission of faculty member in biology. (1-3). (Excl). (BS). (INDEPENDENT). May be repeated for credit for a maximum of 9 credits. Continuing Course. Y grade can be reported at end of the first-term to indicate work in progress. At the end of the second term of MCDB 400, the final grade is posted for both term's elections.

Credits: (1-3).

Course Homepage: No homepage submitted.

Intended for those engaged in original laboratory research at an advanced level. This course number is most frequently elected by senior Honors students who have completed MCDB 300 and who are completing their research and writing their thesis. A final paper is required. (Refer to the description of MCDB 300 for more information.)

The work in this course may continue for two academic terms. A 'Y' grade can be reported at the end of the first-term to indicate work in progress. At the end of the second term of MCDB 400, the final grade is posted for both term's elections. Students interested in MCDB 400 should obtain the brochure MCDB Department Policies on Undergraduate Research from the Undergraduate Biology Program Office (1111 Natural Science Bldg).

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 5, Permission of instructor

MCDB 413(BIOLOGY 413). Plant Molecular Biology Laboratory.

Section 001.

Instructor(s): Eran Pichersky (lelx@umich.edu)

Prerequisites & Distribution: BIOLOGY 310 or 311, or BIOLCHEM 415; and BIOLOGY 305. (3). (Excl). (BS). May not be repeated for credit. Satisfies a Biology laboratory requirement. Laboratory fee ($70) required.

Credits: (3).

Lab Fee: Laboratory fee ($70) required.

Course Homepage: No homepage submitted.

This is a project lab in which students learn to identify and analyze plant genes and gene products using the latest techniques of molecular biology. Emphasis will be on genes encoding unique plant characteristics. Students will first isolate genes from DNA libraries of various plant species. They will then analyze the sequence of genes they have isolated by DNA sequencing, and will characterize their expression levels by various techniques. The genes will then be manipulated to produce the gene products (i.e., proteins) in a bacterial system.

Biochemistry and Molecular Biology of Plants. Buchanan, Gruissem, Jones. Publisher: John Wiley & sons. ISBN 0943088399

Check Times, Location, and Availability Cost: 3 Waitlist Code: 1

MCDB 428(BIOLOGY 428). Cell Biology.

Section 001 — MIDTERM EXAMS WILL BE HELD WEDNESDAYS, FEBRUARY 4TH AND MARCH 17TH, 6-8 PM.

Instructor(s): Jesse C Hay (jessehay@umich.edu) , Kenneth M Cadigan (cadigan@umich.edu)

Prerequisites & Distribution: BIOLOGY 305; and BIOLOGY 310 or 311, or BIOLCHEM 415. (4). (Excl). (BS). May not be repeated for credit. Students with credit for MCDB 320 must obtain permission of instructor.

Credits: (4).

Course Homepage: No homepage submitted.

MCDB 428 is designed to provide students with a comprehensive overview of the biology of eukaryotes and prokaryotes at the cellular and molecular level. This course is intended for upper-level undergraduates and graduate students. The information is presented at a level that requires students to integrate information from their other biology, chemistry, and biochemistry courses. Topics include: cell structure and function; cell membranes; intracellular organelles and cytoskeleton; inter- and intra-cellular signaling; cell development; and cell cycle. Students will be expected to integrate the scientific data presented in class as well as to read and interpret basic research drawn from the current scientific literature. Grades will be based on three exams and the discussion section.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 1

MCDB 429(BIOLOGY 429). Laboratory in Cell and Molecular Biology.

Section 001.

Instructor(s): Kenneth J Balazovich (kbalazo@umich.edu)

Prerequisites & Distribution: MCDB 427 or 428, or concurrent enrollment in MCDB 428. (3). (Excl). (BS). May not be repeated for credit. No credit granted to those who have completed or are enrolled in BIOLCHEM 416 or 516. Satisfies a Biology laboratory requirement. Laboratory fee ($70) required.

Credits: (3).

Lab Fee: Laboratory fee ($70) required.

Course Homepage: http://coursetools.ummu.umich.edu/2004/winter/mcdb/429/001.nsf

This laboratory course encompasses a broad spectrum of common methods and theory essential to Cellular and Molecular Biology concentrations. The 90-minute lecture each week is used to introduce methodology and techniques that will be encountered in the lab. Two weekly lab sessions are arranged in a project-based format. The projects include several kinds of microscopy, cellular organelle isolation, gel electrophoresis, Western blotting, column chromatography and tissue culture, in addition to molecular biology methods such as plasmid construction, transfection, polymerase chain reaction, and Southern blotting. Grades are based on three exams, laboratory quizzes and a semester-long grant proposal project that may be completed individually or in a self-organized group. This course can be used to satisfy requirements for the Cell and Molecular Biology Concentration and the Biology Concentration.

Textbook:
Mandatory: Laboratory DNA Science (Bloom, et al. )
Suggested: Molecular Biology of the Cell (Alberts, et al. )

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 1

MCDB 430(BIOLOGY 430). Molecular Biology of Plants.

Section 001.

Instructor(s): Charles F Yocum (cyocum@umich.edu)

Prerequisites & Distribution: BIOLOGY 305; and 310 or 311, or BIOLCHEM 415. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

The topic of this course is major advances in understanding molecular processes in plants, and the contribution of molecular biological techniques to these advances. The course is intended for advanced undergraduates and beginning graduate students. The course will begin with an overview of the basic techniques of plant molecular biology such as cloning and sequencing of DNA, transformation, and analysis of gene expression. We will then examine selected topics in detail, including proteins, biochemical pathways, photoreception, photosynthesis, and respiration. We will read and then discuss research publications in class. Student performance will be evaluated on the basis of class participation, two take-home examinations, and a term paper.

Biochemistry and Molecular Biology of Plants. Buchanan, Gruissen, Jones. (John Wiley & Sons.) (softbound).

Check Times, Location, and Availability Cost: 3 Waitlist Code: No Data Given.

MCDB 435(BIOLOGY 435). Intracellular Trafficking.

Section 001.

Instructor(s): Jesse C Hay (jessehay@umich.edu)

Prerequisites & Distribution: BIOLOGY 305, BIOLOGY 310, 311, or BIOLCHEM 415, and MCDB 428. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

This is an advanced discussion-oriented course covering the latest research in the field of intracellular trafficking. The course is intended for students with a serious interest in cell biological research. It is intended for advanced, graduate school-bound undergraduates, and first- and second-year graduate students. Topics covered include molecular basis of secretion, vesicle transport, protein targeting, molecular motors, and organelle biogenesis. Students will be presented lectures providing them with enough background to understand specific questions and gaps in our knowledge of intracellular trafficking mechanisms. Most of the class time, however, will be spent discussing current research papers from the primary literature. The emphasis will be on the critical evaluation of these studies' experimental approaches, interpretation of data, and conclusions. There will be two 1.5-hour class periods per week. Students will be assigned problem sets to ensure that they have done the reading before class and have thought sufficiently about the issues involved. The course also will require participation in discussion. In addition, each student will have to present at least one research paper to the class, explain the questions being addressed, techniques, pitfalls, etc.

Check Times, Location, and Availability Cost: 1 Waitlist Code: 1

MCDB 469(BIOLOGY 469). Signal Transduction.

Section 001.

Instructor(s): Kenneth M Cadigan (cadigan@umich.edu)

Prerequisites & Distribution: MCDB 427 or 428. (3). (Excl). (BS). May not be repeated for credit.

Credits: (3).

Course Homepage: No homepage submitted.

This course will cover selected aspects of animal signal transduction, focusing on critical reading and presentation of primary research papers. It will also emphasize the importance of combining genetic and biochemical approaches to gain a better understanding of cellular processes. Topics will include TGF and Notch signaling, MAP kinase cascades, and the tumor suppressor APC. Grades will be determined by discussion in class, an oral presentation and two written assignments. The course is intended for junior or senior CMB concentrators (who have taken either MCDB 427 or 428) and graduate students. The class will meet twice weekly for 90 minutes.

Contact the instructor — cadigan@umich.edu with any questions regarding the course.

Check Times, Location, and Availability Cost: No Data Given. Waitlist Code: 1


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This page was created at 7:39 PM on Wed, Jan 21, 2004.


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