Courses in Biological Chemistry (Division 517)

Since Fall Term, 1992, the Department of Biological Chemistry has been offering a series of consecutive, one-credit modules that can each be elected independently. The first three of these modules (Biological Chemistry 570, 571, and 572) were offered Fall Term 1992. Biological Chemistry 573, 574, 575 are the next courses in the series. they will each last approximately one month (from the start of classes in January), meeting three times a week. The last two modules in the series will be offered beginning Fall Term, 1993.

415. Introductory Biochemistry. Two terms of organic chemistry equivalent to Chem. 225 and 226. No credit granted to those who have completed or are enrolled in Biol. 411. (3-4). (Excl).

This is a one term course in biochemistry. Biochemistry is essentially the identification of the characteristics of living matter. Specifically the course will cover the biochemistry of the living state, the chemistry of biomolecules, energy transformations and chemical reactions in living cells; function of the immune system and action of hormones; self-regulation and self-replication of living organisms. The course begins with a set of 16 objectives in the form of questions, and at the end these objectives are reexamined. The main text is Biochemistry, 3rd ed. by Stryer. Some topics on molecular biology are also covered by Molecular Biology of the Gene, 3rd ed., by Watson. The course is basically a lecture course with handouts provided for emphasis. Four hourly exams and a final examination will be used to evaluate student performance. It is possible to obtain a fourth credit hour by attending an extra series of lectures and preparing a research paper. Cost:2 WL:4 (Zand)

573. Enzyme Kinetics and Ligand Binding. Biol. Chem. 570 or equivalent. Physical chemistry is strongly recommended. (1). (Excl).

A detailed examination of ligand binding and steady-state kinetics, including also a brief treatment of oxidation-reduction potentials. Problem sets will constitute an important component of the course. Written examination at the end of the course. Lectures. Cost:2 WL:4 (Massey and Ding)

574. Catalysis. Biol. Chem. 570 and 573, or equivalent. Physical chemistry is strongly recommended. (1). (Excl).

Introduction to the general principles of enzyme catalysis, including general acid and base catalysis, covalent catalysis, and strain and distortion aspects of catalysis. Selected examples to illustrate those principles will include proteases, discussing kinetics, covalent intermediates, mechanism of catalysis at the active site, and inhibition. Other topics will include isotope effects, stereochemistry, cofactors, and prosthetic groups involved in catalysis with appropriate enzymatic examples such as redox transformations, pyridoxal phosphate catalyzed reactions, and phosphoryl transfer. The course will include 3 exams, each covering an equal amount of material. There will be assigned problem sets involving more thinking than writing. These sets should each take about 2 hours to complete. Lectures. Cost:2 WL:4 (Marletta and Hupe)

575. Signal Transduction. Two terms of organic chemistry; Biol. Chem. 415 or equivalent; or permission of instructor. Physical Chemistry is strongly recommended. (1). (Excl).

This course reviews hormone and neurotransmitter receptors as well as the cellular effectors that are regulated by receptor activation. Oncogene products as signal transducers and the interaction of the known signalling pathways are also covered. The course takes a distinctly biochemical approach to the study of these topics. The various techniques used to study signal transduction as well as important experimental strategies employing these techniques are also presented. Take home problem sets and a final examination are a part of the course. Lectures. Cost:2 WL:4 (Guan and Schacht)


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