415. Introductory Biochemistry. Two terms of organic chemistry. No credit granted to those who have completed or are enrolled in Biol. 310 or 311. (3-4). (Excl). (BS).
A one term introductory biochemistry course that covers the biochemistry of the living state, the chemistry of biomolecules, energy transformations and chemical reactions in living cells, function of the immune system and action of hormones, and self-regulation and self-replication of living organisms. The course begins with a set of 16 objectives in the form of questions, and at the end these objectives are reexamined. The main textbook is Biochemistry, 4th ed., by Stryer. Some topics on molecular biology are also covered by Molecular Biology of the Gene, 3rd ed., by Watson. This is a lecture course with handouts provided for emphasis. Four hourly exams and a final exam are used to evaluate student performance. It is possible to obtain a fourth credit by attending an extra series of lectures once a week and writing a research paper. Cost:3 WL:4 (Zand)
573. Enzyme Kinetics and Ligand Binding. Biol. Chem. 570 or equivalent. Physical chemistry is strongly recommended. (1). (Excl). (BS).
A detailed examination of ligand binding and steady-state kinetics, including also a brief treatment of oxidation-reduction potentials. Problem sets constitute an important component of the course. Cost:2 WL:4 (Massey, Dixon)
574. Catalysis. Biol. Chem. 570 and 573, or equivalent. Physical chemistry is strongly recommended. (1). (Excl). (BS).
Introduction to the general principles of enzyme catalysis, including general acid and base catalysis, covalent catalysis, and strain and distortion aspects of catalysis. Selected examples to illustrate those principles will include proteases, discussing kinetics, covalent intermediates, mechanism of catalysis at the active site, and inhibition. Other topics will include isotope effects, stereochemistry, cofactors, and prosthetic groups involved in catalysis with appropriate enzymatic examples such as redox transformations, pyridoxal phosphate catalyzed reactions, and phosphoryl transfer. The course includes three exams, each covering an equal amount of material. There will be assigned problem sets involving more thinking than writing. These sets should each take about two hours to complete. Lectures. Cost:2 WL:4 (Marletta)
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