00e97d371d96d310VgnVCM100000c2b1d38dRCRDapproved/UMICH/stats/Home/News & Events/Archived Events/2012-2013 EventsJuan Shen###@###(Fri, 7 Sep 2012)Juan Shen###@###(Fri, 7 Sep 2012)438 West HallSubgroup Identification and Analysis Through Logistic-Normal Mixture Modelsstats1347030000000134703000000011:00 AM<p><b>Title: </b>Subgroup Identification and Analysis through Logistic–Normal Mixture Models<br> <b>Advisor: </b>Professor Xuming He<br> <b>Committee Members:</b> Professor Kerby Shedden, Assistant Professor XuanLong Nguyen, Associate Professor Bhramar Mukherjee</p> <p>Abstract: Subgroup analysis is an important problem in clinical trials. For example, when a new treatment is approved for use, there may be concerns that the efficacy is driven by extreme efficacy in a subgroup only. Various methods have been proposed for the examination of subgroup effects. In recent years, researchers often attempt to identify a potential subgroup in which the subjects will have an enhanced treatment effect. In this proposed dissertation, we assume that there exist two potential subgroups in which the subjects react differently to the treatment. We propose a logistic-normal mixture model where the group means as well as the mixing proportions may be covariate-dependent. Testing the existence of subgroups is critical in the mixture model, but requires non-standard statistical tests. We derive a test based on a small number of EM iterations towards the likelihood, and propose the bootstrap approximation for the critical values of the test. When subgroups exist, the mixture model helps us identify the factors that are associated with the group membership. We apply the proposed method to the Aids Clinical Trials Group 320 study, and demonstrate that the patients with higher values of baseline CD4 or RNA tend to benefit significantly more by adding a protease inhibitor to two nucleoside analogues.&nbsp;</p>Njjsantosjjsantos1366829649887dfd97d371d96d310VgnVCM100000c2b1d38d____once11112newnewEvent Flyer/UMICH/stats/Home/Events/Dissertations and Oral Preliminary Examinations/Juan Shen Prelim Flyer.pdfJuan Shen