Research in our laboratory focuses on innovations in modern synthetic organic and organometallic chemistry to address fundamentally interesting questions of biological importance. It has recently been suggested that certain cancer treatments would benefit from targeting both the tumor itself and the resultant inflammation of the surrounding tissue. Inflammation in the tumor microenvironment has many tumor promoting effects that lead to proliferation and survival of malignant cells, angiogenesis and metastasis. The primary goal of our research program is to develop new synthetic methods based on transition metal catalysis to enable the synthesis of biologically active natural and unnatural products. The compounds prepared within this research program will be evaluated for their specific biological activities both by ourselves and in collaborations established within researchers at the University of Michigan and at the Broad Institute of Harvard and MIT.
The structurally complex motifs of our biologically active targets call for innovative synthetic solutions. In turn, students joining this research program will gain expertise not only in the field of complex target synthesis but also the development of creative synthetic methods. We will specifically target new synthetic transformations that enable us to rapidly access common synthetic intermediates en route to our biologically active natural and unnatural products.
C.S. Schindler, L. Bertschi and E.M. Carreira, Angew. Chem. Int. Ed. 2010, 49, 9229-9232. "Total Synthesis of Nominal Banyaside B: Structural Revision of the Glycosylation Site."
C.S. Schindler, S. Diethelm and E.M. Carreira, Angew. Chem. Int. Ed. 2009, 48, 6296-6299. "Nucleophilic Ring Opening of Oxabicyclic Ring Systems."
C.S. Schindler and E.M. Carreira, Chem. Soc. Rev. 2009, 38, 3222-3241. "Rapid Formation of Complexity in the Total Synthesis of Natural Products Enabled by Oxabicyclo[2.2.1]heptane building blocks."
C.S. Schindler, C.R.J. Stephenson and E.M. Carreira, Angew. Chem. Int. Ed. 2008, 47, 8852-8855. ?Enantioselective Synthesis of the Core of Banyaside, Suomilide, and Spumigin HKVV."
K.C. Nicolaou, A.L. Nold, R.R. Milburn, C.S. Schindler, K.P. Cole and J. Yamaguchi, J. Am. Chem. Soc. 2007, 129, 1760-1768. "Total Synthesis of Marinomycins A-C and of Their Monomeric Counterparts Monomarinomycin A and iso-Monomarinomycin A."
K.C. Nicolaou, A.L. Nold, R.R. Milburn and C.S. Schindler, Angew. Chem. Int. Ed. 2006, 45, 6527-6532. "Total Synthesis of Monomarinomycins A-C."
ETH Medal, 2011
Alexander von Humboldt Foundation, Feodor-Lynen Postdoctoral Fellowship, 2010-12
Roche Research Foundation, Predoctoral Fellowship, Switzerland, 2008
Bayerische EliteAkademie, Munich, Germany, 2004
Fritz-ter-Meer Foundation, Bayer AG, Germany, 2004
Kurt Fordan Foundation, Munich, Germany, 2004
Kurt Wamsler Foundation, Munich, Germany, 2004