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830 N. University
Office Location(s): 4071B Nat. Sci.Lab Address: 4081, 4084, 4085 Nat. Sci. 734.615.0272
Li Lab Website
Both animals and plants use steroids as signaling molecules to regulate a variety of growth and developmental processes; however, their signaling mechanisms are quite different. While animal steroids are mainly recognized by intracellular steroid receptors that provide a fast track for the chemical signals to move into the nucleus for controlling gene activities, plants steroids are perceived by a transmembrane receptor kinase that initiates a phosphorylation-mediated signal transduction pathway. For the last several years, my lab, along with several other plant steroid research groups, has identified several key regulators of the plant steroid signaling using Arabidopsis as our genetic model system. Currently, we are taking a combinatory approach of biochemistry, molecular biology, genetics, and chemical genetics to uncover additional components of the plant steroid signal transduction pathway and to study detailed biochemical mechanisms of each individual signaling component for transducing the steroid signal from the cell surface to the nucleus.
Molecular, Cellular, and Developmental Biology
Kraus Natural Science Building830 N. University Ave.
Ann Arbor, MI