After obtaining a B.Sc. in Biochemistry from the University of Leeds in England, Georgios Skiniotis moved to Germany to pursue his Ph.D. in the group of Dr. Andreas Hoenger at the European Molecular Biology Laboratory in Heidelberg. At EMBL, while receiving further training in biochemistry and molecular biology, he specialized in electron cryomicroscopy and helical reconstructions to study the interaction of kinesin motors with microtubules. Resulting in numerous publications, his structural and biochemical work on kinesin-microtubule complexes provided significant new insights to the "walking" mechanism of molecular motors.
Following the completion of his Ph.D., and with an ever-growing fascination for the visualization of protein complexes by electron microscopy, Dr. Skiniotis crossed the Atlantic to join the lab Dr. Thomas Walz at Harvard Medical School in Boston. In Harvard, where he was awarded with the prestigious Damon Runyon fellowship, he strengthened his electron microscopy background with the application of single particle analysis techniques for the structural investigation of macromolecular complexes. Besides his work on structural studies of RSC, a 15-subunit chromatin remodeling machine in yeast, he also engaged in collaborations for the structural characterization of several signaling cell surface receptors, such as gp130, LIF-R, and the Vascular Endothelial Growth Factor Receptor (VEGF-R).
Dr. Skiniotis joined LSI as a Biological Sciences Scholar and Research Assistant Professor in 2008. His primary research focus is the application of molecular electron microscopy for the exploration of chromatin modifying complexes and the mechanisms involved in nucleosome remodeling. In addition, he continues working on cell surface receptors and the ways their extracellular architectures instigate intracellular signaling.
Skiniotis Lab Page
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