An overview of nested genes in eukaryotic genomes

Author(s): Anuj Kumar

Nested Genes


For more than 30 years, we have understood that genes may be organized within genomic DNA in complex spatial arrangements. In particular, gene-coding sequences can overlap: a given segment of genomic DNA can encode more than one gene product, with the overlapping genes often oriented on opposite strands. In some cases, the overlapping genes are organized such that one gene is entirely contained within the chromosomal region occupied by another gene. In such instances, the internal gene is referred to as a "nested" gene. Formally, a nested gene is defined as any gene whose entire coding sequence lies within the chromosomal region bounded by the start codon and stop codon of a larger external gene

Publication Information:

Name of Periodical: Eukaryotic Cell

Volume Number: 8

Issue Number: 9

Year of Publication: 2009