Author(s): Anuj Kumar
Description:
For more than 30 years, we have understood that genes may be organized within genomic DNA in complex spatial arrangements. In particular, gene-coding sequences can overlap: a given segment of genomic DNA can encode more than one gene product, with the overlapping genes often oriented on opposite strands. In some cases, the overlapping genes are organized such that one gene is entirely contained within the chromosomal region occupied by another gene. In such instances, the internal gene is referred to as a "nested" gene. Formally, a nested gene is defined as any gene whose entire coding sequence lies within the chromosomal region bounded by the start codon and stop codon of a larger external gene
Publication Information:
Name of Periodical: Eukaryotic Cell
Volume Number: 8
Issue Number: 9
Year of Publication: 2009
