Research in the Duan lab is directed towards understanding how peptide growth factors act to control vertebrate development, growth, and aging. Our current research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. The Duan lab uses mammals, zebrafish and other fish as experimental models. A combination of molecular, cell biological, biochemical, genetic, and genomic approaches are used to address physiological and developmental questions. Specific areas of current research activity include: (1) roles of growth factors in regulating cell proliferation, differentiation, migration and apoptosis during early development; (2) signal transduction mechanisms of growth factor actions; (3) transcriptional and post-transcriptional regulation of gene expression; and (4) roles of growth factors and hormones in regulating development, growth, and aging in response to hypoxia and nutrient restriction.
Dr. Duan received his B.S. degree from the Ocean University of China and his Ph.D. degree from the University of Tokyo. He was a postdoctoral research associate at the University of Washington and a postdoctoral fellow at the University of North Carolina at Chapel Hill.
Recent Representative Publications
Zhang, P., Yao, Q., Lu, L., Li, Y., P-J. Chen and Duan, C. (2014) Hypoxia inducible factor-3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Rep., in press
W Dai, Y Bai, L Hebda, X Zhong, J Liu1J Kao and C Duan (2013) Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation, Cell Death and Differentiation, in press. (ePub December 13, 2013 doi:10.1038/cdd.2013.177)
Allard, J., Kamei, H., and Duan, C. (2013) Inducible transgenic expression in the short-lived fish, Nothobranchius furzeri. J. Fish Biol. 82:1733-1738.
Zhou, J., Xiang, J., Zhang, S., and Duan, C. (2013) Structural and functional analysis of the amphioxus IGFBP gene uncovers ancient origin of IGF-independent functions. Endocrinology, 154:3753-63.
Zhang, C., Lu, L., Li, Y., Zhou, J., Liu, Y., Fu, P., Gallicchio, M.A., Bach, L.A. and Duan, C. (2012) IGF binding protein 6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis. Int. J. Cancer, 130:2003-2012.
Onuma, T.A. and Duan, C. (2012) Duplicated Kiss1 receptor genes in zebrafish: Distinct gene expression patterns, different ligand selectivity, and a novel nuclear isoform with transactivating activity. FASEB J, 26: 2941-2950.
Zhong, Y., Lu, L., Zhou, J. Li, Y., Liu, Y., Clemmons, D.R., and Duan, C. (2011) IGF binding protein 3 exerts its IGF-independent action by antagonizing BMP in zebrafish. J. Cell Sci. 124:1925-35.
Onuma, T.A., Ding, Y., Abraham, E., Zohar, Y., Ando, H., Duan, C. (2011) Regulation of temporal and spatial organization of newborn GnRH neurons by IGF signaling in zebrafish. J. Neuroscience, 31: 11814-11824.
Kamei, H., Ding, Y., Kajimura, S., Wells, M., Chiang, P. and Duan, C. (2011) Role of IGF signaling in catch-up growth and accelerated temporal development in zebrafish embryos in response to oxygen availability. Development. 138: 777-786.
Dai, W., Kamei, H., Zhao, Y., Ding, J., Du, Z., and Duan, C. (2010). Duplicated zebrafish insulin-like growth factor binding protein-5 genes with split functional domains: Evidence for evolutionarily conserved IGF binding, nuclear localization, and transactivation activity. FASEB J. 24:2020-9.
Ren, H., Accili, D., and Duan, C. (2010). Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways. Proc. Natl. Acad. Sci. USA. 107:5857-62.