The major interest in my lab is to study the regulation of synaptic connections during development, maturity and aging. One major approach is to use state-of-the-art imaging methods to study the dynamics of synaptic proteins at single synapses in living animals. We are using a variety of fluorescent proteins (YFP,GFP) transgenic and synaptic proteins deficient mice to study the regulation of synaptic dynamics at simple and accessible synapse like the neuromuscular junction. In addition to new optical imaging tools, we are using innovative molecular techniques to eventually better understand the cellular and molecular mechanisms underlying synaptic plasticity at single synapses in normal and pathological situations.
Dr. Akaaboune received his DEA and Ph.D. from the University of Pierre and Marie Curie (Paris 6) in Paris, France. He was postdoctoral fellow in Lichtman's laboratory at Washington University School of Medicine in St. Louis, Missouri.
Research Interests: Synaptic development and synaptic plasticity, postsynaptic proteins dynamics, and neuromuscular diseases.
He has been awarded the highly prestigious Human Frontier Science Program Postdoctoral Fellowship, and he was a finalist in the 1999 James L. O'Leary Prize Competition in Neuroscience. He was also an NIH and French Medical Research Fellow.
Isabel Martinez-Pena y Valenzuela, Mohamed Aittaleb, Po-Ju Chen, and Mohammed Akaaboune. The knockdown of akap alters the postsynaptic apparatus of neuromuscular junctions in living mice. Journal of Neuroscience. 2015 (in press)
Emile G. Bruneau, Daniel S. Brenner, John Y. Kuwada and Akaaboune M. Acetylcholine receptors are required for the insertion and maintenance of post-synaptic scaffolding proteins. (2008). Current Biology 2008. Jan 22;18(2):109-15. PDF
Bruneau E, Sutter D, Hume RI, and Mohammed Akaaboune. Identification of Nicotinic Acetylcholine Receptor Recycling and its Role in Maintaining Receptor Density at the Neuromuscular Junction in vivo. (2005). Journal of Neuroscience. 25:9949-59. PDF
Akaaboune M, Grady RM, Turney S, Sanes JR, and Lichtman JW. Neurotransmitter Receptor Dynamics Studied in vivo by Reversible Photo-Unbinding of Fluorescent Ligands. (2002). Neuron. 34: 865-876. PubMed
Akaaboune M., Culican S.M., Turney S.G., Lichtman J.W. Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo. (1999). Science (Research Article). 28: 503-7. PubMed