This course will provide a high-level overview on the structure, function and chemistry of biological macromolecules including proteins, nucleic acids and carbohydrates. Topics include protein and nucleic acid folding, energetic of macromolecular interactions (kinetics and thermodynamics), and mechanistic enzymology. Using specific examples from the current literature, each topic will stress how chemists have used molecular level tools and probes to help understand the specific systems under study. The over arching theme in this course will be the structure and function and intimately linked.