"You're crazy." Many of us are familiar with this common saying, but how often do we stop to think about where it comes from -- and what it might mean, in a social context, to call someone, or to be called, crazy? In this course, we will examine historical and contemporary ideas of madness, mental illness, and mental health, teasing apart how, why, and when these ideas are, or are not, used interchangeably by social actors. Within and across social contexts, we will explore vernacular and institutional approaches to these ideas -- religious, political, medical, carceral, and so on -- paying particular attention to emerging global markets for psychopharmaceuticals. How, we will ask, does anthropology develop our understanding of how humans think about, talk about, and experience distress and wellbeing?