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830 N. Univerisity
Office Location(s): 4140D Nat. Sci.Lab Address: 4140 Nat. Sci.
Telomeres (protein-DNA complex) and telomerase (protein-RNA enzymatic complex) are specialized protein-nucleic acid complexes found at the ends of chromosomes. They play vital roles in ensuring genome stability and stem cell viability, respectively. Additionally, illicit activation of telomerase is a hallmark of a overwhelming majority of cancers, qualifying this enzyme as a prime target for anti-cancer drug development. We use biochemical, cell biological and X-ray crystallographic tools to understand how these complexes are assembled in cells and how they perform their critical biological functions at chromosome ends.
Molecular, Cellular, and Developmental Biology
Kraus Natural Science Building830 N. University Ave.
Ann Arbor, MI