Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways

Author(s): Hongxia Ren, Domenico Accili, Cunming Duan

Myogenic action


Professor Cunming Duan and his research team have cleared up a long standing mystery about the workings of insulin-like growth factors (IGFs).

The team's findings, published online in the Proceedings of the National Academy of Sciences, could lead to new treatments for muscle wasting diseases and new ways of preventing the muscle loss that accompanies aging. "[A] major reason that muscle atrophy occurs as people get older is that the IGF signal gets weaker. If we can find a way to affect IGF signaling, we may be able to stop or reverse the loss," Duan said

Publication Information:

Name of Periodical: PNAS

Year of Publication: 2010