Three Distinct Condensin Complexes Control C. elegans Chromosome Dynamics

Author(s): Gyorgyi Csankovszki, Karishma Collette, Karin Spahl, James Carey, Martha Snyder, Emily Petty, Uchita Patel, Tomoko Tabuchi, Hongbin Liu, Ian McLeod, James Thompson, Ali Sarkesik, John Yates, Barbara J. Meyer, Kirsten Hagstrom

Condensin Complexes


Condensin complexes organize chromosome structure and facilitate chromosome segregation. Higher eukaryotes have two complexes, condensin I and condensin II, each essential for chromosome segregation. The nematode Caenorhabditis elegans was considered an exception, because it has a mitotic condensin II complex but appeared to lack mitotic condensin I. Instead, its condensin I-like complex (here called condensin IDC) dampens gene expression along hermaphrodite X chromosomes during dosage compensation. Here we report the discovery of a third condensin complex, condensin I, in C. elegans. We identify new condensin subunits and show that each complex has a conserved five-subunit composition.

Publication Information:

Name of Periodical: Curr. Biol.

Volume Number: 19

Issue Number: 1

Year of Publication: 2008