415. Introductory Biochemistry. Two terms of organic chemistry equivalent to Chem. 225 and 226. No credit granted to those who have completed or are enrolled in Biol. 311. (3-4). (Excl). (BS).
A one term introductory biochemistry course that covers the biochemistry of the living state, the chemistry of biomolecules, energy transformations and chemical reactions in living cells, function of the immune system and action of hormones, and self-regulation and self-replication of living organisms. The course begins with a set of 16 objectives in the form of questions, and at the end these objectives are reexamined. The main textbook is Biochemistry, 3rd ed., by Stryer. Some topics on molecular biology are also covered by Molecular Biology of the Gene, 3rd ed., by Watson. This is a lecture course with handouts provided for emphasis. Four hourly exams and a final exam are used to evaluate student performance. It is possible to obtain a fourth credit hour by attending an extra series of lectures once a week and writing a research paper. Cost:3 WL:4 (Zand)
573. Enzyme Kinetics and Ligand Binding. Biol. Chem. 570 or equivalent. Physical chemistry is strongly recommended. (1). (Excl). (BS).
A detailed examination of ligand binding and steady-state kinetics, including also a brief treatment of oxidation-reduction potentials. Problem sets constitute an important component of the course. Cost:2 WL:4 (Massey & Peliska)
574. Catalysis. Biol. Chem. 570 and 573, or equivalent. Physical chemistry is strongly recommended. (1). (Excl). (BS).
Introduction to the general principles of enzyme catalysis, including general acid and base catalysis, covalent catalysis, and strain and distortion aspects of catalysis. Selected examples to illustrate those principles will include proteases, discussing kinetics, covalent intermediates, mechanism of catalysis at the active site, and inhibition. Other topics will include isotope effects, stereochemistry, cofactors, and prosthetic groups involved in catalysis with appropriate enzymatic examples such as redox transformations, pyridoxal phosphate catalyzed reactions, and phosphoryl transfer. The course includes 3 exams, each covering an equal amount of material. There will be assigned problem sets involving more thinking than writing. These sets should each take about 2 hours to complete. Lectures. Cost:2 WL:4 (Marletta)
575. Signal Transduction. Two terms of organic chemistry; Biol. Chem. 415 or equivalent; or permission of instructor. Physical Chemistry is strongly recommended. (1). (Excl). (BS).
This course reviews hormone and neurotransmitter receptors as well as the cellular effectors that are regulated by receptor activation. Oncogene products as signal transducers and the interaction of the known signalling pathways are also covered. The course takes a distinctly biochemical approach to the study of these topics. The various techniques used to study signal transduction as well as important experimental strategies employing these techniques are also presented. Take home problem sets and a final examination are a part of the course. Lectures. Cost:2 WL:4 (Guan & L. Mathews)
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